Aggression in humans correlates with cerebrospinal fluid amine metabolites

doi:10.1016/0165-1781(79)90053-2

Psychiatry Research

Volume 1, Issue 2, October 1979, Pages 131-139

https://doi.org/10.1016/0165-1781(79)90053-2 Get rights and content

Abstract

Cerebrospinal fluid levels of the major central metabolites of serotonin (5HT), norepinephrine (NE), and dopamine (DA)—5-hydroxyindoleacetic acid (5HIAA), 3-methoxy-4-hydroxy-phenylglycol (MHPG), and homovanillic acid (HVA), respectively—were studied in a group of 26 age-similar military men with no history of major pyschiatric illness, but with various personality disorders and difficulties adjusting to military life. Independently scored history of aggressive behavior showed a significant negative correlation with 5HIAA (r = -0.78) and a significant positive correlation with MHPG (r = 0.64).

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^☆: The opinions or assertions in this article are those of the authors and are not to be construed as official or reflecting the views of the Navy Department or the Naval Service at large.

^∗: The authors thank Marcia D. Minichiello (NIMH) for assistance in data analysis, and V.M. Holm and O.L. Royal (Captains, U.S. Navy) for assistance with patient material.

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Aggression in humans correlates with cerebrospinal fluid amine metabolites☆

Abstract

Life Sciences

Neuropharmacology

Pharmacology, Biochemistry, and Behavior

Pharmacology, Biochemistry, and Behavior

Biochemical Medicine

European Journal of Pharmacology

European Journal of Pharmacology

Life Sciences

Journal of the American Academy of Child Psychiatry

Biochemical Pharmacology

Biochemical Pharmacology

Biochemical Pharmacology

Life Sciences

International Journal of Neuropharmacology

Comprehensive Psychiatry

DSM-II: Diagnostic and Statistical Manual of Mental Disorders

“Serotonin depression”—A biochemical subgroup within the affective disorders?

Science

5-HIAA in the cerebrospinal fluid

Archives of General Psychiatry

Measurement of acid monoamine metabolites in human CSF

British Journal of Pharmacology

Chromosome errors and antisocial behavior

Critical Reviews in Clinical Laboratory Sciences

Association between fighting behavior and catecholamine biosynthetic enzymes in two sublines of an inbred mouse strain

Proceedings of the National Academy of Sciences of the United States of America

Pharmacokinetics of oral tryptophan in drug-free psychiatric patients

Plasma tryptophan tolerance curves in drug-free normal controls, schizophrenic patients and prisoner volunteers

Journal of Psychiatric Research

The catecholamines and aggressive behavior

The aggressive moniamines

Biological Psychiatry

Rubidium and cesium: Effects on aggression, adrenal enzymes, and amine turnover

Federation Proceedings