Obstetrical complications in patients with bipolar disorder and their siblings

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Abstract

Although indirect evidence suggests that obstetric complications are risk factors for bipolar disorders, few studies have directly addressed this question. Probands with bipolar disorder and their adult siblings were diagnosed according to DSM-III-R criteria by clinicians who had no knowledge of the subjects' obstetrical histories. Hospital records on gestations and births of 16 probands and 20 of their siblings without major mood disorders were scored for obstetric complications without knowledge of diagnosis. The assessment of obstetrical history was based on rating scales that have proved reliable and that reflect the number and severity of complications. Overall complication scores were significantly more severe in probands than siblings. Differences were most marked for perinatal complications.

References (36)

  • L.E. DeLisi et al.

    Clinical features of illness in siblings with schizophrenia or schizoaffective disorder

    Archives of General Psychiatry

    (1987)
  • D.J. Done et al.

    Complications of pregnancy and delivery in relation to psychosis in adult life: Data from the British perinatal mortality survey sample

    British Medical Journal

    (1991)
  • F.K. Goodwin et al.

    Manic-Depressive Illness

    (1990)
  • B. Jacobsen et al.

    Perinatal complications in adopted and non-adopted samples of schizophrenics and controls

    Acta Psychiatrica Scandinavica

    (1980)
  • J. Kennell et al.

    Continous emotional support during labor in a US hospital: A randomized controlled trial

    Journal of the American Medical Association

    (1991)
  • D.K. Kinney

    Schizophrenia and major affective disorders

  • D.K. Kinney et al.

    Neurologic abnormalities in schizophrenic patients and their families: II. Neurologic and psychiatric findings in relatives

    Archives of General Psychiatry

    (1986)
  • J.P. Manshande et al.

    Rest versus heavy work during the last weeks of pregnancy: Influence on fetal growth

    British Journal of Obstetrics and Gynaecology

    (1987)
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    Dennis K. Kinney, Ph.D., and Deborah L. Levy, Ph.D., are Associate Psychologists; Deborah A. Yurgelun-Todd, Ph.D., is Assistant Research Psychologist; and David Medoff, Clara M. Lajonchere, and Meg Radford-Paregol are research interns, Laboratories for Psychiatric Research, McLean Hospital, and Department of Psychiatry, Harvard Medical School.

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