Psychiatry Research
Volume 149, Issue 1 , Pages 97-104 , 15 January 2007

Olfactory sensitivity through the course of psychosis: Relationships to olfactory identification, symptomatology and the schizophrenia odour

  • Warrick J. Brewer

      Affiliations

    • ORYGEN Research Centre, Melbourne, Victoria, Australia
    • Corresponding Author InformationCorresponding author. ORYGEN Research Centre (Locked Bag 10), Parkville, Vic. 3052, Australia. Tel.: +61 3 9342 2800; fax: +61 3 9342 2858.
    • ,
  • Stephen J. Wood

      Affiliations

    • Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Victoria, Australia
    • Brain Research Institute, Melbourne, Victoria, Australia
    • ,
  • Christos Pantelis

      Affiliations

    • Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Victoria, Australia
    • Howard Florey Institute, University of Melbourne, Victoria, Australia
    • ,
  • Gregor E. Berger

      Affiliations

    • ORYGEN Research Centre, Melbourne, Victoria, Australia
    • ,
  • David L. Copolov

      Affiliations

    • Monash University, Melbourne, Australia
    • ,
  • Patrick D. McGorry

      Affiliations

    • ORYGEN Research Centre, Melbourne, Victoria, Australia

Received 27 March 2005 ,Revised 22 December 2005 ,Accepted 6 March 2006.

References 

  1. Adams R, Victor M. Principles of Neurology. New York: McGraw Hill; 1985;
  2. Albone ES, Shirley SG. Mammalian Semiochemistry. The Investigation of Chemical Signals Between Mammals. New York: John Wiley; 1984;
  3. Bird S, Gower DB. Axillary 5-alpha-androst-16-en-3-one, cholesterol and squalene in men: preliminary evidence for 5-alpha-androst-16-en-3-one being a product of bacterial action. Journal of Steroidal Biochemistry. 1982;17:517–522
  4. Bradley EA. Olfactory acuity to a pheromonal substance and psychotic illness. Biological Psychiatry. 1984;19:899–905
  5. Brewer WJ, Edwards J, Anderson V, Robinson T, Pantelis C. Neuropsychological, olfactory, and hygiene deficits in men with negative symptom schizophrenia. Biological Psychiatry. 1996;40:1021–1031
  6. Brewer WJ, Wood SJ, McGorry PD, Francey SM, Phillips LJ, Yung , et al. Olfactory identification ability is impaired in individuals at ultra high-risk for psychosis who later develop schizophrenia. American Journal of Psychiatry. 2003;160:1790–1794
  7. Brooksbank BWL, Pryse-Phillips W. Urinary alpha-16-androsten-3alpha-ol, 17-oxosteroids and mental illness. British Medical Journal. 1964;20:1602–1606
  8. Clark, T.O., Ball, R., 1987. Sensitivities to five putative human pheromones in a population of young male service recruits. Mimeograph. From Pharmabulletin 80, Health Commission of Victoria: Publisher.
  9. Dalton P, Doolittle N, Breslin PA. Gender-specific induction of enhanced sensitivity to odors. Nature Neuroscience. 2002;5:199–200
  10. Doty RL, Brugger WE, Jurs PC, et al. Intranasal trigeminal stimulation from odorous volatiles: psychometric responses from anosmic and normal individuals. Physiological Behavior. 1978;20:175–185
  11. Doty R, Shaman P, Dann W. Development of the University of Pennsylvania Smell Test: standardised micro-encapsulated test of olfactory function. Physiological Behavior. 1984;32:489–502
  12. Doty RL, McKeown DA, Lee WW, Shaman P. A study of the test–retest reliability of ten olfactory tests. Chemical Senses. 1995;20:645–656
  13. Fennig S, Kovasznay B, Rich C, Ram R, Pato C, Miller A, et al. Six-month stability of psychiatric diagnoses in first-admission patients with psychosis. American Journal of Psychiatry. 1994;151(8):1200–1208
  14. Geddes J, Huws R, Pratt P. Olfactory acuity in the positive and negative symptoms of schizophrenia. Biological Psychiatry. 1991;29:774–778
  15. Gordon SG, Smith K, Rabinowitz JL, Vagelos PR. Studies of trans-3-methyl-2-hexenoic acid in normal and schizophrenic humans. Journal of Lipid Research. 1973;14:495–503
  16. Gower DB, Bird PS, House FR. Axillary 5-alpha-androst-16-en-3-one in men and women: relationships with olfactory acuity to odorous 16-androstenes. Experientia. 1985;41:1134–1136
  17. Hubert HB, Fabsitz RR, Feinlab M, Brown KS. Science. 1980;208:608–609
  18. Hubert HB, Fabsitz RR, Brown KS, Feinlab M. In:  Gedda L,  Parise P,  Nance WE editor. Twin Research 3: Epidemiological and Clinical Studies. New York: Liss; 1981;p. 97–103
  19. Jones-Gotman M, Zatorre RJ. Olfactory identification deficits in patients with focal cerebral excision. Neuropsychologia. 1988;26:387–400
  20. Kloek J. The smell of some steroid sex-hormones and their metabolites. Psychiatry, Neurology and Neurochemistry. 1961;64:309–344
  21. Koelega HS, Koster EP. Some experiments on sex differences in odor perception. Annals of the New York Academy of Sciences. 1974;237:234–246
  22. Kopala L, Clark C, Hurwitz TA. Sex differences in olfactory function in schizophrenia. American Journal of Psychiatry. 1989;146:1320–1322
  23. Kopala L, Clark C, Hurwitz T. Olfactory deficits in neuroleptic naive patients with schizophrenia. Schizophrenia Research. 1992;8:245–250
  24. Kopala LC, Good KP, Koczapski AB, Honer WG. Olfactory deficits in patients with schizophrenia and severe polydipsia. Biological Psychiatry. 1998;43:497–502
  25. Krawiecka M, Goldberg D, Vaughan M. A standardised psychiatric assessment scale for rating chronic psychotic patients. Acta Psychiatrica Scandinavica. 1977;55:299–308
  26. Liddell K. Smell as a diagnostic marker. Postgraduate Medical Journal. 1976;52:136–138
  27. Mackay-Sim A, Doty RL. The University of Pennsylvania Smell Identification Test: normative adjustment for Australian norms. Australian Journal of Otolaryngology. 2001;4(3):174–177
  28. Malnic B, Godfrey PA, Buck LB. The human olfactory receptor gene family. Proceedings of the National Academy of Sciences. 2004;101:2584–2589
  29. Martzke JS, Kopala LC, Good KP. Olfactory dysfunction in neuropsychiatric disorders: review and methodological considerations. Biological Psychiatry. 1997;42:721–732
  30. McGorry PD, Dosseter CR, Kaplan I, McKenzie D, Van Riel RJ, Singh BS, et al. Royal Park Multidiagnostic Instrument for Psychosis (RPMIPS). Parkville, Australia: NH&MRC Schizophrenia Research Unit; 1989;
  31. Moberg PJ, Agrin R, Gur RE, Gur RC, Turetsky BI, Doty RL. Olfactory dysfunction in schizophrenia: a qualitative and quantitative review. Neuropsychopharmacology. 1999;21:325–340
  32. Nelson HE, O'Connell A. Dementia: the estimation of pre-morbid intelligence levels using the new adult reading test. Cortex. 1978;14:234–244
  33. Perry TJ, Melancon SB, Lesk D, Hansen S. Failure to detect trans-3-methyl-2-hexenoic acid in the sweat of schizophrenic patients. Clinical Chimica Acta. 1970;30:721–725
  34. Potter H, Butters N. An assessment of olfactory deficits in patients with damage to prefrontal cortex. Neuropsychologia. 1980;18:621–628
  35. Purdon SE, Klein S, Flor-Henry P. Menstrual effects on asymmetrical olfactory acuity. Journal of the International Neuropsychological Society. 2001;7:703–709
  36. Roberts MA. Some possible pathways for the synthesis of trans-3-methyl-2 hexenoic acid. Orthomolecular Psychiatry. 1980;9(2):129–134
  37. Sirota P, Davidson B, Mosheva T, Benhatov R, Zohar J, Gross-Isseroff R. Increased olfactory sensitivity in first episode psychosis and the effect of neuroleptic treatment on olfactory sensitivity in schizophrenia. Psychiatry Research. 1999;86:143–153
  38. Smith RV, Leong A. Methods for the preparation of trans-3-methyl-2-hexenoic acid, the malodorous component of schizophrenics' sweat. Journal of Pharmaceutical Sciences. 1972;61:316–317
  39. Smith K, Sines JO. Demonstration of a peculiar odour in the sweat of schizophrenic patients. Archives of General Psychiatry. 1960;2:184–188
  40. Smith K, Thompson GF, Koster HD. Sweat in schizophrenic patients: identification of odorous substance. Science. 1969;166:398–399
  41. Spitzer RL, Williams JBW, Gibbons M. Structured Clinical Interview for DSM-III-R (SCID-R). New York: New York State Psychiatric Institute, Biometrics Research; 1988;
  42. Stoddart DM. Mammalian Odours and Pheromones. Southampton: Camelot Press; 1976;
  43. Wiener H. External chemical messengers. I. Emission and reception in man. New York State Journal of Medicine. 1966;3153–3171(Dec 15)
  44. Wiener H. External chemical messengers, II. Natural history of schizophrenia. New York State Journal of Medicine. 1967;1144–1151(May 1)
  45. Willshire D, Kinsella G, Prior M. Estimating WAIS-R IQ from the National Adult Reading Test: a cross-validation. Journal of Clinical and Experimental Neuropsychology. 1990;13(2):204–216
  46. Wu J, Buschbaum MS, Moy K, Denlea N, Kesslak P, Tseng H, et al. Olfactory memory in unmedicated schizophrenics. Schizophrenia Research. 1993;9:41–47
  47. Wysocki CJ, Beauchamp GK. Ability to smell androstenone is genetically determined. Proceedings of the National Academy of Sciences. 1984;81:4899–4902
  48. Wysocki CJ, Gilbert AN. National Geographic Smell Survey: effects of age are heterogeneous. Annals of the New York Academy of Sciences. 1989;561:12–48

PII: S0165-1781(06)00077-1

doi: 10.1016/j.psychres.2006.03.005

Psychiatry Research
Volume 149, Issue 1 , Pages 97-104 , 15 January 2007

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