A mixed modality paradigm for recording somatosensory and auditory P50 gating

Arnfred, Sidse M; Chen, Andrew C.N; Eder, Derek N; Glenthøj, Birte Y; Hemmingsen, Ralf P

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Volume 105, Issue 1 , Pages 79-86, 15 December 2001

A mixed modality paradigm for recording somatosensory and auditory P50 gating

Sidse M Arnfred
- Department of Psychiatry, University Hospital of Copenhagen, Bispebjerg, Bispebjerg Bakke 23, DK-2400 København NV, Denmark
- Mobile: +45-22-16-35-25.
- Corresponding author. Tel.: +45-35-31-26-61; fax: +45-35-31-39-53
Andrew C.N Chen
- Human Brain Mapping and Cortical Imaging Laboratory, The International Doctoral School in Biomedical Sciences and Engineering, SMI, Aalborg University, DK-9220 Aalborg, Denmark
Derek N Eder
- Institute of Clinical Neuroscience, Section of Psychiatry, Göteborg University, SU/Sahlgrenska, SE-413 45 Göteborg, Sweden
Birte Y Glenthøj
- Department of Psychiatry, University Hospital of Copenhagen, Bispebjerg, Bispebjerg Bakke 23, DK-2400 København NV, Denmark
Ralf P Hemmingsen
- Department of Psychiatry, University Hospital of Copenhagen, Bispebjerg, Bispebjerg Bakke 23, DK-2400 København NV, Denmark

Received 15 February 2001; received in revised form 27 August 2001; accepted 20 September 2001.

Abstract

Significant somatosensory evoked potential (SEP) P50 gating has previously been found in young healthy men by the use of identical paired stimuli. In this study, the exploration of the gating paradigm was extended with the addition of a mixed modality paradigm where three different pairs of identical stimuli (clicks, right median nerve electric stimulations and proprioceptive stimuli of changing load on a handheld weight) were presented over a 12-s cycle. In both modalities repeated measures analyses of variance demonstrated no effect of paradigm. This mixed-modality recording paradigm could be used in further experiments to examine gating deficits across modalities.

Keywords: Evoked potential, Median nerve stimulation, Habituation