Psychiatry Research
Volume 109, Issue 1 , Pages 93-96 , 31 January 2002

Lack of evidence for associations between plasma platelet-activating factor acetylhydrolase deficiency and schizophrenia

  • Tsuyuka Ohtsuki

      Affiliations

    • Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki-ken, 305-8575 Japan
    • ,
  • Hideki Watanabe

      Affiliations

    • Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki-ken, 305-8575 Japan
    • ,
  • Michio Toru

      Affiliations

    • Department of Neuropsychiatry, Tokyo Medical and Dental University School of Medicine, 113-8549, Tokyo, Japan
    • ,
  • Tadao Arinami

      Affiliations

    • Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki-ken, 305-8575 Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-298-53-3352; fax: +81-298-53-3333

Received 22 June 2001 ,Revised 19 November 2001 ,Accepted 23 November 2001.

References 

  1. Aihara M, Ishii S, Kume K, Shimizu T. Interaction between neurone and microglia mediated by platelet-activating factor. Genes to Cells. 2000;5:397–406
  2. Bell R, Collier DA, Rice SQ, Roberts GW, MacPhee CH, Kerwin RW, et al. Systematic screening of the LDL-PLA2 gene for polymorphic variants and case–control analysis in schizophrenia. Biochemical and Biophysical Research Communications. 1997;241:630–635
  3. Calcerrada MC, Catalan RE, Martinez AM. Glutamate release is involved in PAF-increased cyclic GMP levels in hippocampus. Biochemistry and Molecular Biology International. 1999;47:529–535
  4. Chen C, Bazan NG. Platelet-activating factor inhibits ionotropic GABA receptor activity in cultured hippocampal neurons. Neuroreport. 1999;10:3831–3835
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  6. Hiramoto M, Yoshida H, Imaizumi T, Yoshimizu N, Satoh K. A mutation in plasma platelet-activating factor acetylhydrolase (Val279→Phe) is a genetic risk factor for stroke. Stroke. 1997;28:2417–2420
  7. Kruse S, Mao XQ, Heinzmann A, Blattmann S, Roberts MH, Braun S, et al. The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma. American Journal of Human Genetics. 2000;66:1522–1530
  8. Oken RJ, Schulzer M. At issue: schizophrenia and rheumatoid arthritis: the negative association revisited. Schizophrenia Bulletin. 1999;25:625–638
  9. Satoh N, Asano K, Naoki K, Fukunaga K, Iwata M, Kanazawa M, et al. Plasma platelet-activating factor acetylhydrolase deficiency in Japanese patients with asthma. American Journal of Respiratory and Critical Care Medicine. 1999;159:974–979
  10. Stafforini DM, McIntyre TM, Carter ME, Prescott SM. Human plasma platelet-activating factor acetylhydrolase. Association with lipoprotein particles and role in the degradation of platelet-activating factor. Journal of Biological Chemistry. 1987;262:4215–4222
  11. Stafforini DM, Numao T, Tsodikov A, Vaitkus D, Fukuda T, Watanabe N, et al. Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma. Journal of Clinical Investigation. 1999;103:989–997
  12. Stafforini DM, Satoh K, Atkinson DL, Tjoelker LW, Eberhardt C, Yoshida H, et al. Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase. Journal of Clinical Investigation. 1996;97:2784–2791
  13. Tabuchi S, Kume K, Aihara M, Ishii S, Mishina M, Shimizu T. Lipid mediators modulate NMDA receptor currents in a Xenopus oocyte expression system. Neuroscience Letters. 1997;237:13–16
  14. Teather LA, Packard MG, Bazan NG. Differential interaction of platelet-activating factor and NMDA receptor function in hippocampal and dorsal striatal memory processes. Neurobiology of Learning and Memory. 2001;75:310–324

PII: S0165-1781(01)00353-5

Psychiatry Research
Volume 109, Issue 1 , Pages 93-96 , 31 January 2002

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