Psychiatry Research
Volume 109, Issue 3 , Pages 255-264 , 15 April 2002

Neuropsychological performance in medicated vs. unmedicated patients with obsessive–compulsive disorder

  • David Mataix-Cols

      Affiliations

    • Department of Psychiatry, Imperial College School of Medicine (Division of Neuroscience and Psychological Medicine), Stress Self-Help Clinic, 303 North End Road, London W14 9NS, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44-207-610-2594; fax: +44-207-385-7471
  • ,
  • Pino Alonso

      Affiliations

    • Department of Psychiatry, Bellvitge University Hospital, Barcelona, Catalonia, Spain
  • ,
  • Josep Pifarré

      Affiliations

    • Department of Psychiatry, Santa Maria Hospital, Lleida, Catalonia, Spain
  • ,
  • Josep Manuel Menchón

      Affiliations

    • Department of Psychiatry, Bellvitge University Hospital, Barcelona, Catalonia, Spain
  • ,
  • Julio Vallejo

      Affiliations

    • Department of Psychiatry, Bellvitge University Hospital, Barcelona, Catalonia, Spain

Received 22 August 2001 ,Revised 24 January 2002 ,Accepted 6 February 2002.

References 

  1. Allen D, Curran HV, Lader M. The effects of repeated doses of clomipramine and alprazolam on physiological, psychomotor and cognitive functions in normal subjects. European Journal of Clinical Psychopharmacology. 1991;40:355–362
  2. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC: American Psychiatric Press; 1994;
  3. Bangs ME, Petti TA, Janus M-D. Fluoxetine-induced memory impairment in an adolescent. Journal of the American Academy of Child and Adolescent Psychiatry. 1994;33:1303–1306
  4. Bartfai A, Åsberg M, Mårtensson B, Gustavsson P. Memory effects of clomipramine treatment: relationship to CSF monoamine metabolites and drug concentrations in plasma. Biological Psychiatry. 1991;30:1075–1092
  5. Baxter LR, Schwartz JM, Guze BH, Bergman K, Szuba M. Neuroimaging in obsessive–compulsive disorder: seeking the mediating neuroanatomy. In:  Jenike MA,  Baer L,  Minichiello WE editor. Obsessive-Compulsive Disorders. Theory and Management. Littleton: Year Book Medical Publishers; 1990;p. 167–188
  6. Beck AT, Ward CH, Mendelsohn M, Mock JE, Erbaugh JK. An inventory for measuring depression. Archives of General Psychiatry. 1961;4:561–571
  7. Beers SR, Rosenberg DR, Dick EL, Williams T, O'Hearn KM, Birmaher B, et al. Neuropsychological study of frontal lobe function in psychotropic-naive children with obsessive–compulsive disorder. American Journal of Psychiatry. 1999;156:777–779
  8. Bradley SJ, Kulil L. Fluoxetine and memory impairment [Letter]. Journal of the American Academy of Child and Adolescent Psychiatry. 1993;32:1078–1079
  9. Christensen KJ, Kim SW, Dysken MW, Hoover KM. Neuropsychological performance in obsessive–compulsive disorder. Biological Psychiatry. 1992;31:4–18
  10. Cornblatt BA, Risch NJ, Faris G, Friedman D, Erlenmeyer-Kimling L. The continuous performance test, identical pairs version (CPI-IP): I. New findings about sustained attention in normal families. Psychiatry Research. 1988;26:223–238
  11. Deckersbach T. Effects of Panic Disorder and Benzodiazepines on Memory. Unpublished Ph.D. Dissertation. Germany: University of Marburg; 1999;
  12. Desai N, Taylor-Davie A, Barnett DB. The effects of diazepam and oxoprenolol on short-term memory in individuals of high and low state anxiety. British Journal of Clinical Pharmacology. 1983;15:197–202
  13. Detpula D, Pomara N. Effects of antidepressants on human performance: a review. Journal of Clinical Pharmacology. 1990;10:105–111
  14. Fudge JL, Perry PJ, Garvey MJ, Kelly MW. A comparison of the effect of fluoxetine and trazodone on the cognitive functioning of depressed outpatients. Journal of Affective Disorders. 1990;18:275–280
  15. Goodman WK, Price LH, Rasmussen SA, Mazure C, Delgado P, Heninger GR, et al. The Yale–Brown Obsessive-Compulsive Scale (Y-BOCS). Part I: Development, use and reliability. Archives of General Psychiatry. 1989;46:1006–1011
  16. Head D, Bolton D, Hymas N. Deficit in cognitive shifting ability in patients with obsessive–compulsive disorder. Biological Psychiatry. 1989;25:929–937
  17. Heaton RK. Wisconsin Card Sorting Test Manual, 4th ed. Odessa, FL: Psychological Assessment Resources; 1981;
  18. Hindmarch I, Shillingford J, Shillingford C. The effects of sertraline on psychomotor performance in elderly volunteers. Journal of Clinical Psychiatry. 1990;51:34–36
  19. Hoehn-Saric R, Harris GJ, Pearlson GD, Cox CS, Machlin SR, Camargo EE. A fluoxetine-induced frontal lobe syndrome in an obsessive compulsive patient. Journal of Clinical Psychiatry. 1991;52:131–133
  20. Lezak MD. Neuropsychological Assessment, 3rd ed. New York: Oxford University Press; 1995;
  21. Martin A, Wiggs CL, Altemus M, Rubenstein C, Murphy DL. Working memory as assessed by subject-ordered tasks in patients with obsessive–compulsive disorder. Journal of Clinical and Experimental Neuropsychology. 1995;17:786–792
  22. Mataix-Cols D. Neuroimagen y neuropsicologia del trastorno obsesivo-compulsivo: avances recientes [Neuroimaging and neuropsychology of obsessive–compulsive disorder: recent advances]. Psiquiatrı́a Biológica. 2001;8(2):54–63
  23. Mataix-Cols D, Barrios M, Sànchez-Turet M, Vallejo J, Junqué C. Reduced design fluency in sub-clinical obsessive–compulsive subjects. Journal of Neuropsychiatry and Clinical Neurosciences. 1999;11:395–397
  24. Mirrow S. Cognitive dysfunction associated with fluoxetine [Letter]. American Journal of Psychiatry. 1991;148:948–949
  25. Modell JG, Mountz JM, Curtis GC, Greden JF. Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive compulsive disorder. Journal of Neuropsychiatry and Clinical Neurosciences. 1989;1:27–36
  26. Moskowitz H, Burns M. The effects on performance of two antidepressants, alone and in combination with diazepam. Progress in Neuropsychopharmacology and Biological Psychiatry. 1988;12:783–792
  27. Newcombe F. Missile Wounds of the Brain, 3rd ed. London: Oxford University Press; 1969;
  28. Petrides M, Milner B. Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man. Neuropsychologia. 1982;20:249–262
  29. Purcell R, Maruff P, Kyrios M, Pantelis C. Cognitive deficits in obsessive–compulsive disorder on tests of frontal-striatal function. Biological Psychiatry. 1998;43:348–357
  30. Rapoport JL. Obsessive–compulsive disorder and basal ganglia dysfunction. Psychological Medicine. 1990;20:465–469
  31. Raven JC, Court JH, Raven J. Raven, Matrices Progresivas. Escala Superior (Spanish adaptation from APM: Advanced Progressive Matrices), 3rd ed. Madrid: TEA; 1996;
  32. Richardson JS, Keegan DL, Bowen RC, Blachshaw SL, Cebrian Perez S, Dayal N, et al. Verbal learning by major depressive disorder patients during treatment with fluoxetine or amitriptyline. International Clinical Psychopharmacology. 1994;9:35–40
  33. Savage CR. Neuropsychology of OCD: research findings and treatment implications. In:  Jenike MA,  Baer L,  Minichiello WE editor. Obsessive–Compulsive Disorders: Practical Management, 3rd ed. St. Louis, MO: Mosby; 1998;p. 254–275
  34. Savage CR, Baer L, Keuthen NJ, Brown HD, Rauch SL, Jenike MA. Organizational strategies mediate nonverbal memory impairment in obsessive–compulsive disorder. Biological Psychiatry. 1999;45:905–916
  35. Savage CR, Deckersbach T, Wilhelm S, Rauch SL, Baer L, Reid T, et al. Strategic processing and episodic memory impairment in obsessive compulsive disorder. Neuropsychology. 2000;14:141–151
  36. Schmitt JAJ, Kruizinga MJ, Riedel WJ. Non-serotonergic pharmacological profiles and associated cognitive effects of serotonin reuptake inhibitors. Journal of Psychopharmacology. 2001;15(3):173–179
  37. Simon HA. The functional equivalence of problem solving skills. Cognitive Psychology. 1975;7:268–288
  38. Skoog G, Skoog I. A 40-year follow-up of patients with obsessive–compulsive disorder. Archives of General Psychiatry. 1999;56:121–127
  39. Spielberger CD, Gorsuch RL, Lushene RE. Cuestionario de Ansiedad Estado-Rasgo [Spanish adaptation from the Manual for the State-Trait Anxiety Inventory], 3rd ed. Madrid: TEA; 1982;
  40. Stanley MA, Turner SM. Current status of pharmacological and behavioral treatment of obsessive–compulsive disorder. Behavior Therapy. 1995;26:163–186

PII: S0165-1781(02)00024-0

Psychiatry Research
Volume 109, Issue 3 , Pages 255-264 , 15 April 2002