Trait dissociation affects the behavioral response to cholecystokinin tetrapeptide in healthy man

Kellner, Michael; Yassouridis, Alexander; Hua, Yun; Wendrich, Mona; Naber, Dieter; Wiedemann, Klaus

« PreviousPsychiatry Research
Volume 111, Issue 1 , Pages 93-96, 5 August 2002

Trait dissociation affects the behavioral response to cholecystokinin tetrapeptide in healthy man

Michael Kellner
- Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany
- Corresponding author. Tel.: +49-40-42803-2234; fax: +49-40-42803-3461
Alexander Yassouridis
- Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany
Yun Hua
- Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany
Mona Wendrich
- Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany
Dieter Naber
- Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany
Klaus Wiedemann
- Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany

Received 5 September 2001; received in revised form 2 May 2002; accepted 28 May 2002.

Abstract

Trait dissociation might influence the response to panicogens in normal controls. The behavioral effects of 25 μg of cholecystokinin tetrapeptide (CCK-4) were studied in 18 healthy men, nine each with high or low trait dissociation. Subjects with high trait dissociation showed a significantly lower increase of acute dissociative, anxiety and panic symptoms compared with subjects with low trait dissociation. Trait dissociation should be assessed in further behavioral challenge studies as a potentially important covariate.

Keywords: Dissociative Experiences Scale, Cholecystokinin, Anxiety Sensitivity Index, Tetrapeptide, Panic, Anxiety, Dissociation