Psychiatry Research
Volume 120, Issue 1 , Pages 1-12 , 30 August 2003

Prepulse inhibition of acoustic startle in subjects with schizophrenia treated with olanzapine or haloperidol

  • Erica Duncan

      Affiliations

    • Emory University School of Medicine, Atlanta, GA, USA
    • Mental Health Service/116A, Atlanta Veterans Affairs Medical Center, 1670 Clairmont Road, Decatur, GA 30033, USA
    • Corresponding Author InformationCorresponding author. Mental Health Service/116A, VAMC, 1670 Clairmont Rd., Decatur, GA 30033, USA. Tel.: +1-404-321-6111; fax: +1-404-417-2911
    • ,
  • Sandor Szilagyi

      Affiliations

    • Department of Veterans Affairs New York Harbor Healthcare System, New York, NY, USA
    • ,
  • Marion Schwartz

      Affiliations

    • Department of Veterans Affairs New York Harbor Healthcare System, New York, NY, USA
    • ,
  • Alena Kunzova

      Affiliations

    • Department of Veterans Affairs New York Harbor Healthcare System, New York, NY, USA
    • ,
  • Shobhit Negi

      Affiliations

    • Department of Veterans Affairs New York Harbor Healthcare System, New York, NY, USA
    • ,
  • Toby Efferen

      Affiliations

    • Department of Veterans Affairs New York Harbor Healthcare System, New York, NY, USA
    • ,
  • Eric Peselow

      Affiliations

    • Department of Veterans Affairs New York Harbor Healthcare System, New York, NY, USA
    • New York University School of Medicine, New York, NY, USA
    • ,
  • Subhajit Chakravorty

      Affiliations

    • Department of Veterans Affairs New York Harbor Healthcare System, New York, NY, USA
    • ,
  • Myrsini Stephanides

      Affiliations

    • Department of Veterans Affairs New York Harbor Healthcare System, New York, NY, USA
    • ,
  • James Harmon

      Affiliations

    • Emory University School of Medicine, Atlanta, GA, USA
    • ,
  • Dragana Bugarski-Kirola

      Affiliations

    • Emory University School of Medicine, Atlanta, GA, USA
    • ,
  • Stephen Gonzenbach

      Affiliations

    • Department of Veterans Affairs New York Harbor Healthcare System, New York, NY, USA
    • ,
  • John Rotrosen

      Affiliations

    • Department of Veterans Affairs New York Harbor Healthcare System, New York, NY, USA
    • New York University School of Medicine, New York, NY, USA

Received 25 July 2002 ,Revised 8 May 2003 ,Accepted 12 June 2003.

References 

  1. Bakshi VP, Swerdlow NR, Geyer MA. Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response. Journal of Pharmacology and Experimental Therapeutics. 1994;271:787–794
  2. Bakshi VP, Geyer MA. Antagonism of phencyclidine-induced deficits in prepulse inhibition by the putative atypical antipsychotic olanzapine. Psychopharmacology. 1995;122:198–201
  3. Bolino F, Manna V, DiCicco L, DiMichele V, Daneluzzo E, Rossi A, et al. Startle reflex habituation in functional psychoses: a controlled study. Neuroscience Letters. 1992;142:126–128
  4. Bolino F, DiMichele V, DiCicco L, Manna V, Daneluzzo E, Cassachia M. Sensorimotor gating and habituation evoked by electro-cutaneous stimulation in schizophrenia. Biological Psychiatry. 1994;36:670–679
  5. Braff D, Stone C, Callaway E, Geyer M, Glick I, Bali L. Prestimulus effects of human startle reflex in normals and schizophrenics. Psychophysiology. 1978;15:339–343
  6. Braff DL, Geyer MA. Sensorimotor gating and schizophrenia. Human and animal model studies. Archives of General Psychiatry. 1990;47:181–188
  7. Braff DL, Geyer MA, Light GA, Sprock J, Perry W, Cadenhead KS, et al. Impact of prepulse characteristics on the detection of sensorimotor gating deficits in schizophrenia. Schizophrenia Research. 2001;49:171–178
  8. Braff DL, Grillon C, Geyer MA. Gating and habituation of the startle reflex in schizophrenic patients. Archives of General Psychiatry. 1992;49:206–215
  9. Braff DL. Information processing and attention dysfunctions in schizophrenia. Schizophrenia Bulletin. 1993;19:233–259
  10. Braff DL, Swerdlow NR, Geyer MA. Symptom correlates of prepulse inhibition deficits in male schizophrenic patients. American Journal of Psychiatry. 1999;156:596–602
  11. Butler RW, Jenkins MA, Geyer MA, Braff DL. Wisconsin Card Sorting deficits and diminished sensorimotor gating in a discrete subgroup of schizophrenic patients. In:  Tamminga CA,  Schulz SC editor. Schizophrenia Research: Advances in Neuropsychiatry and Psychopharmacology. New York: Raven Press; 1991;p. 163–168
  12. Cadenhead KS, Geyer MA, Braff DL. Impaired startle prepulse inhibition and habituation in patients with schizotypal personality disorder. American Journal of Psychiatry. 1993;150(12):1862–1867
  13. Cadenhead KS, Swerdlow NR, Shafer KM, Diaz M, Braff DL. Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: evidence of inhibitory deficits. American Journal of Psychiatry. 2000;157:1660–1668
  14. Davis M. Neurochemical modulation of sensory-motor reactivity: acoustic and tactile startle reflexes. Neuroscience and Biobehavioral Reviews. 1980;4:241–263
  15. Davis M. The neurophysiological basis of acoustic startle modulation: research on fear motivation and sensory gating. In:  Lang PJ,  Simons RF,  Balaban MT editor. Attention and Orienting: Sensory and Motivational Processes. London: Lawrence Erlbaum Associates; 1997;p. 69–96
  16. Davis M, Gendelman DS, Tischler MD, Gendelman PM. A primary acoustic startle circuit: lesion and stimulation studies. Journal of Neuroscience. 1982;2:791–805
  17. Davis M, Mansbach RS, Swerdlow NR, Campeau S, Braff DL, Geyer MA. Apomorphine disrupts the inhibition of acoustic startle induced by weak prepulse in rats. Psychopharmacology. 1990;102:1–4
  18. Duncan EJ, Madonick SH, Parwani A, Angrist B, Rajan R, Chakravorty S, et al. Clinical and sensorimotor gating effects of ketamine in normals. Neuropsychopharmacology. 2001;25:72–83
  19. Duncan EJ, Szilagyi S, Efferen TR, Schwartz MP, Parwani A, Chakravorty S, et al. Effect of treatment status on prepulse inhibition of acoustic startle in schizophrenia. Psychopharmacology. 2003;167:63–71
  20. Fendt M, Li L, Yeomans JS. Brain stem circuits mediating prepulse inhibition of the startle reflex. Psychopharmacology. 2001;156:216–224
  21. Fiefel D, Priebe K. The effects of subchronic haloperidol on intact and dizocilpine-disrupted sensorimotor gating. Psychopharmacology. 1999;146:175–179
  22. Geyer MA, Braff DL. Habituation of the blink reflex in normals and schizophrenic patients. Psychophysiology. 1982;19:1–6
  23. Geyer MA, Braff DL. Startle habituation and sensorimotor gating in schizophrenia and related animal models. Schizophrenia Bulletin. 1987;13(4):643–668
  24. Geyer MA, Krebs-Thomson K, Braff DL, Swerdlow NR. Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review. Psychopharmacology. 2001;156:117–154
  25. Grillon C, Ameli R, Charney DS, Krystal J, Braff DL. Startle gating deficits occur across prepulse intensities in schizophrenic patients. Biological Psychiatry. 1992;32:939–943
  26. Graham FK. The more or less startling effects of weak prestimulation. Psychophysiology. 1975;12:238–248
  27. Hamm AO, Weike AI, Schupp HT. The effect of neuroleptic medication on prepulse inhibition in schizophrenia patients: current status and future issues. Psychopharmacology. 2001;156:259–265
  28. Hoffman HS, Searle JL. Acoustic and temporal factors in the evocation of startle. Journal of Acoustic Society of America. 1968;43:269–282
  29. Hoffman HS, Ison JR. Reflex modification and the analysis of sensory processing in developmental and comparative research. In:  Campbell BA,  Hayne H,  Richardson R editor. Attention and Information Processing in Infants and Adults: Perspectives from Human and Animal Research. Hillsdale, NJ: Erlbaum; 1992;
  30. Hoffman HS. Attentional factors in the elicitation and modification of the startle reaction. In:  Lang PJ,  Simons RF,  Balaban MT editor. Attention and Orienting: Sensory and Motivational Processes. Mahwah, NJ: Lawrence Erlbaum Associates; 1997;
  31. Javitt DC, Zukin SR. Recent advances in the phencyclidine model of schizophrenia. American Journal of Psychiatry. 1991;148:1301–1308
  32. Johansson C, Jackson DM, Zhang J, Swensson L. Prepulse inhibition of acoustic startle, a measure of sensorimotor gating: effects of antipsychotics and other agents in rats. Pharmacology, Biochemistry and Behavior. 1995;52(4):649–654
  33. Karper LP, Freeman GK, Grillon C, Morgan CAIII, Charney DS, Krystal JH. Preliminary evidence of an association between sensorimotor gating and distractibility in psychosis. Journal of Neuropsychiatry and Clinical Neuroscience. 1996;8:60–66
  34. Koch M. The neurobiology of startle. Progress in Neurobiology. 1999;59:107–128
  35. Koch M, Bubser M. Deficient sensorimotor gating after 6-hydroxydopamine lesion of the rat medial prefrontal cortex is reversed by haloperidol. European Journal of Neuroscience. 1994;6:1837–1845
  36. Kumari V, Sharma T. Effects of typical and atypical antipsychotic on prepulse inhibition in schizophrenia: a critical evaluation of current evidence and directions for future research. Psychopharmacology. 2002;162:97–101
  37. Kumari V, Soni W, Gray JA, Sharma T. Prepulse inhibitory deficits in schizophrenia: the effects of typical and atypical antipsychotic drugs. Journal of Psychopharmacology (Suppl A). 1998;12:A67
  38. Kumari V, Soni W, Sharma T. Normalization of information processing deficits in schizophrenia with clozapine. American Journal of Psychiatry. 1999;156:1046–1051
  39. Kumari V, Soni W, Sharma T. Prepulse inhibition of the startle response in risperidone-treated patients: comparison with typical antipsychotics. Schizophrenia Research. 2002;55:139–146
  40. Kumari V, Soni W, Mathew V, Sharma T. Prepulse inhibition of the startle response in men with schizophrenia. Archives of General Psychiatry. 2000;57:609–614
  41. Leumann L, Feldon J, Vollenweider FX, Ludewig K. Effects of typical and atypical antipsychotics on prepulse inhibition and latent inhibition in chronic schizophrenia. Biological Psychiatry. 2002;52:729–739
  42. Mackeprang T, Kristiansen KT, Glenthoj BY. Effects of antipsychotics on prepulse inhibition of the startle response in drug-naive schizophrenic patients. Biological Psychiatry. 2002;52:863–873
  43. Mansbach R, Braff DL, Geyer MA. Prepulse inhibition of the acoustic startle response is disrupted by N-ethyl-3,4-methylenedioxyamphetamine (MDEA) in the rat. European Journal of Pharmacology. 1989;167:49–55
  44. Mansbach RS, Geyer MA. Effects of phencyclidine and phencyclidine biology on sensorimotor gating in the rat. Neuropsychopharmacology. 1989;2:299–308
  45. Mansbach R, Geyer MA, Braff DL. Dopaminergic stimulation disrupts sensorimotor gating in rat. Psychopharmacology. 1988;94:507–514
  46. Martinez ZA, Oostwegel J, Geyer MA, Ellison GD, Swerdlow NR. ‘Early’ and ‘late’ effects of sustained haloperidol on apomorphine- and phencyclidine-induced sensorimotor gating deficits. Neuropsychopharmacology. 2000;23:517–527
  47. McGhie A, Chapman J. Disorders of attention and perception in early schizophrenia. British Journal of Medical Psychology. 1961;34:103–116
  48. Olney JW, Farber NB. Glutamate receptor by dysfunction and schizophrenia. Archives of General Psychiatry. 1995;52:998–1007
  49. Oranje B, Gispen-de Wied CC, Verbaten MN, Kahn RS. Modulating sensory gating in healthy volunteers: the effects of ketamine and haloperidol. Biological Psychiatry. 2002;52:887–895
  50. Oranje B, van Oel CJ, Gispen-de Wied CC, Verbaten MN, Kahn RS. Effects of typical and atypical antipsychotics on the prepulse inhibition of the startle reflex in patients with schizophrenia. Journal of Clinical Psychopharmacology. 2002;22:359–365
  51. Overall JE, Gorham DR. The Brief Psychiatric Rating Scale. Psychological Reports. 1962;10:799–812
  52. Parwani A, Duncan EJ, Bartlett E, Madonick SH, Efferen TR, Rajan R, et al. Impaired prepulse inhibition of acoustic startle in schizophrenia. Biological Psychiatry. 2000;47:662–669
  53. Perry W, Braff DL. Information-processing deficits and thought disorder in schizophrenia. American Journal of Psychiatry. 1994;151(3):363–367
  54. Perry W, Feifel D, Minassian A, Bhattacharjie I, Braff DL. Information processing deficits in acutely psychotic schizophrenia patients medicated and unmedicated at the time of admission. American Journal of Psychiatry. 2002;159:1375–1381
  55. Perry W, Geyer MA, Braff DL. Sensorimotor gating and thought disturbance measured in close temporal proximity in schizophrenic patients. Archives of General Psychiatry. 1999;56(3):277–281
  56. Pietraszek M, Ossowska K. Chronic treatment with haloperidol diminishes the phencyclidine-induced sensorimotor gating deficit in rats. Naunyn–Schmiedebergs Archives of Pharmacology. 1998;357:466–471
  57. Schall U, Schon A, Zerbin D, Eggers C, Oades RD. Event-related potentials during an auditory discrimination with prepulse inhibition in patients with schizophrenia, obsessive–compulsive disorder and healthy subjects. International Journal of Neuroscience. 1996;84:15–33
  58. Schell AM, Dawson ME, Hazlett EA, Filion DL. Attentional modulation of startle in psychosis-prone college students. Psychophysiology. 1995;32:266–273
  59. Simons RF, Giardina BD. Reflex modification in psychosis-prone young adults. Psychophysiology. 1992;29:8–16
  60. Swerdlow NR, Bakshi V, Waikar M, Taaid N, Geyer MA. Seroquel, clozapine and chlorpromazine restore sensorimotor gating in ketamine-treated rats. Psychopharmacology. 1998;140:75–80
  61. Swerdlow NR, Braff D, Geyer M. Limbic cortico-striato-pallido-pontine substrates of sensorimotor gating in animal models and psychiatric disorders. In:  Kalivas PW,  Barnes CD editor. Limbic Motor Circuits and Neuropsychiatry. Ann Arbor, MI: CRC Press; 1993;p. 311–328
  62. Swerdlow NR, Braff DL, Geyer MA, Koob GF. Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics. Biological Psychiatry. 1986;21:23–33
  63. Swerdlow NR, Geyer MA. Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia. Schizophrenia Bulletin. 1998;24(2):285–301
  64. Swerdlow NR, Geyer MA, Braff DL. Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges. Psychopharmacology. 2001;156:194–215
  65. Swerdlow NR, Keith VA, Braff DL, Geyer MA. Effects of spiperone, raclopride, SCH 23390 and clozapine on apomorphine inhibition of sensorimotor gating of the startle response in the rat. Journal of Pharmacology and Experimental Therapeutics. 1991;256:530–536
  66. Swerdlow NR, Mansbach RS, Geyer MA, Pulvirenti L, Koob GF, Braff DL. Amphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine. Psychopharmacology. 1990;100:413–416
  67. Van Berckel BNM, Orange B, van Ree JM, Verbaten MN, Kahn RS. The effects of low dose ketamine on sensory gating, neuroendocrine secretion and behavior in healthy human subjects. Psychopharmacology. 1998;137:271–281
  68. Varty GB, Higgins GA. Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs. Psychopharmacology. 1995;122:15–26
  69. Venables P. Input dysfunction in schizophrenia. In:  Maher BA editors. Progress in Experimental Personality Research. Orlando, FL: Academic Press; 1964;
  70. Weike AI, Bauer U, Hamm AO. Effective neuroleptic medication removes prepulse inhibition deficits in schizophrenia patients. Biological Psychiatry. 2000;47:61–70
  71. Yamada S, Harano M, Annoh N, Nakamura K, Tanaka M. Involvement of serotonin 2A receptors in phencyclidine-induced disruption of prepulse inhibition of the acoustic startle in rats. Biological Psychiatry. 1999;46:832–838

PII: S0165-1781(03)00161-6

doi: 10.1016/S0165-1781(03)00161-6

Psychiatry Research
Volume 120, Issue 1 , Pages 1-12 , 30 August 2003

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