Psychiatry Research
Volume 120, Issue 1 , Pages 37-42 , 30 August 2003

Effect of light therapy on biopterin, neopterin and tryptophan in patients with seasonal affective disorder

  • Rocco Hoekstra

      Affiliations

    • DeltaBouman Psychiatric Teaching Hospital, Postbus 800, Poortugaal 3170 DZ, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31-10-4936515; fax: +31-10-4936514
  • ,
  • Durk Fekkes

      Affiliations

    • Department of Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands
  • ,
  • Ben J.M. van de Wetering

      Affiliations

    • DeltaBouman Psychiatric Teaching Hospital, Postbus 800, Poortugaal 3170 DZ, The Netherlands
  • ,
  • Lolke Pepplinkhuizen

      Affiliations

    • Department of Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands
  • ,
  • Willem M.A. Verhoeven

      Affiliations

    • Department of Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands

Received 3 September 2002 ,Revised 15 May 2003 ,Accepted 28 May 2003.

References 

  1. Abou-Saleh MT, Anderson DN, Collins J, Hughes K, Cattell RJ, Hamon CG, et al. The role of pterins in depression and the effects of antidepressive therapy. Biological Psychiatry. 1995;38:458–463
  2. Anderson DN, Abou-Saleh MT, Collins J, Hughes K, Cattell RJ, Hamon CG, et al. Pterin metabolism in depression: an extension of the amine hypothesis and possible marker of response to ECT. Psychological Medicine. 1992;22:863–869
  3. Auerbach G, Nar H. The pathway from GTP to tetrahydrobiopterin: three-dimensional structures of GTP cyclohydrolase I and 6-pyruvoyl tetrahydropterin synthase. Biological Chemistry. 1997;378:185–192
  4. Barford PA, Blair JA, Eggar C, Hamon C, Morar C, Whitburn SB. Tetrahydrobiopterin metabolism in the temporal lobe of patients dying with senile dementia of Alzheimer type. Journal of Neurology, Neurosurgery and Psychiatry. 1984;47(7):736–738
  5. Coppen A, Swade C, Jones SA, Armstrong RA, Blair JA, Leeming RJ. Depression and tetrahydrobiopterin: the folate connection. Journal of Affective Disorders. 1989;16:103–107
  6. Dunbar PR, Hill J, Neale TJ, Mellsop GW. Neopterin measurement provides evidence of altered cell-mediated immunity in patients with depression, but not with schizophrenia. Psychological Medicine. 1992;22:1051–1057
  7. Fekkes D, Dalen van A, Edelman E, Voskuilen A. Validation of the determination of amino acids in plasma by high-performance liquid chromatography using automated derivatization with o-phthaldialdehyde. Journal of Chromatography B. 1995;669:177–186
  8. Fekkes D, van Gool AR. Interferon, tryptophan and depression. Acta Neuropsychiatrica. 2003;15:8–14
  9. Fernstrom J, Wurtman R. Brain serotonin content: physiological regulation by plasma neutral amino acids. Science. 1972;178:414–416
  10. Hoekstra R, van den Broek WW, Fekkes D, Bruijn JA, Mulder PGH, Pepplinkhuizen L. Effect of ECT treatment on biopterin and large neutral amino acids in severe, medication resistant depression. Psychiatry Research. 2001;103(2–3):115–123
  11. Lam RW, Gorman CP, Michalon M, Steiner M, Levitt AJ, Corral MR, et al. A multi-centre, placebo-controlled study of fluoxetine in seasonal affective disorder. American Journal of Psychiatry. 1995;152:1765–1770
  12. Levine RA. Tetrahydrobiopterin and biogenic amine metabolism in neuropsychiatry, immunology and aging. Annals of the New York Academy of Sciences. 1988;521:129–139
  13. Maes M, Scharpé S, Meltzer HY, Okayli G, Bosmans E, D'Hondt P, et al. Increased neopterin and interferon-gamma secretion and lower availability of l-tryptophan in major depression: further evidence for an immune response. Psychiatry Research. 1994;54:143–160
  14. McGrath RE, Buckwald B, Resnick EV. The effect of l-tryptophan on seasonal affective disorder. Journal of Clinical Psychiatry. 1990;51(4):162–163
  15. Meesters Y, Jansen JHC. Assessing atypical seasonal affective disorder complaints by means of self-rating. Acta Psychiatrica Scandinavica. 1993;88:361–363
  16. Mersch PPA, Middendorp HM, Bouhuys AL, Beersma DGM, van den Hoofdakker RH. The prevalence of seasonal affective disorder in the Netherlands: a prospective and retrospective study of seasonal mood variation in the general population. Biological Psychiatry. 1999;45:1013–1022
  17. Neumeister A, Konstantinidis A, Praschak-Rieder N, Willeit M, Hilger E, Stastny J, et al. Monoaminergic function in the pathogenesis of seasonal affective disorder. International Journal of Neuropsychopharmacology. 2001;4(4):409–420
  18. Neumeister A, Praschak-Rieder N, Hesselmann B, Vitouch O, Rauh M, Barocka A, et al. Effects of tryptophan depletion in fully remitted patients with seasonal affective disorder during summer. Psychological Medicine. 1998;28(2):257–264
  19. Partonen T, Lonnqvist J. Seasonal affective disorder. Lancet. 1998;352(9137):1369–1374
  20. Rosenthal NE, Sack DA, Gillin JC, Lewy AJ, Goodwin FK, Davenport Y, et al. Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy. Archives of General Psychiatry. 1984;41:72–80
  21. Schwartz PJ, Turner EH, Garcia-Borreguero D, Sedway J, Vetticad RG, Wehr TA, et al. Serotonin hypothesis of winter depression: behavioral and neuroendocrine effects of the 5-HT (1A) receptor partial agonist ipsipirone in patients with seasonal affective disorder and healthy control subjects. Psychiatry Research. 1999;86(1):9–28
  22. Stastny J, Konstantinidis A, Schwarz MJ, Rosenthal NE, Vitouch O, Kasper S, et al. Effects of tryptophan depletion and catecholamine depletion on immune parameters in patients with seasonal affective disorder in remission with light therapy. Biological Psychiatry. 2003;53(4):332–337
  23. Wallin MS, Rissanen AM. Food and mood: relationship between food, serotonin and affective disorders. Acta Psychiatrica Scandinavica. 1994;377(suppl.):36–40
  24. Willeit M, Praschak-Rieder N, Neumeister A, Pirker W, Asenbaum S, Vitouch O, et al. [123]-Beta-CIT SPECT imaging shows reduced brain serotonin transporter availability in drug-free depressed patients with seasonal affective disorder. Biological Psychiatry. 2000;47:482–489
  25. Wolf WA, Ziaja E, Arthur RA, Anastasiadis PZ, Levine RA, Kuhn DM. Effect of tetrahydrobiopterin on serotonin synthesis, release and metabolism in superfused hippocampal slices. Journal of Neurochemistry. 1991;57:1191–1197

PII: S0165-1781(03)00167-7

doi: 10.1016/S0165-1781(03)00167-7

Psychiatry Research
Volume 120, Issue 1 , Pages 37-42 , 30 August 2003