Psychiatry Research
Volume 120, Issue 1 , Pages 103-105, 30 August 2003

Gender differences in the effect of repetitive transcranial magnetic stimulation in schizophrenia

  • Thomas J. Huber

      Affiliations

    • Department of Clinical Psychiatry and Psychotherapy, Medical School Hannover, Carl-Neuberg-Strasse 1, D-30627 Hannover, Germany
    • Corresponding Author InformationCorresponding author Tel.: +49-0511-532-2404; fax: +49-0511-532-2415
    • ,
  • Udo Schneider

      Affiliations

    • Department of Clinical Psychiatry and Psychotherapy, Medical School Hannover, Carl-Neuberg-Strasse 1, D-30627 Hannover, Germany
    • ,
  • Jens Rollnik

      Affiliations

    • Department of Clinical Neurology und Neurophysiology, Medical School Hannover, D-30627 Hannover, Germany

Received 22 October 2002; accepted 22 January 2003.

Abstract 

Repetitive transcranial magnetic stimulation (rTMS) can be beneficial in schizophrenia, possibly through a reversal of pre-treatment hypofrontality. Twelve schizophrenic patients (8 men, 4 women) were treated with high-frequency rTMS of the dominant dorsolateral prefrontal cortex. Their performance of the number-connection test, which assesses cognitive processes related to the frontal lobe, was evaluated before and after rTMS. Women improved markedly on the test after rTMS, whereas men did not show a significant change. There were no corresponding sex differences in clinical measures after rTMS. The preliminary findings of sex differences in the response to rTMS, as reflected by performance on the number-connection test, suggest the need for investigations of a greater number of schizophrenic men and women with a more intensive examination of the effects of rTMS on cognitive functions.

Keywords: Sex difference, Number-connection test, Frontal lobe, Cognition

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PII: S0165-1781(03)00170-7

doi:10.1016/S0165-1781(03)00170-7

Psychiatry Research
Volume 120, Issue 1 , Pages 103-105, 30 August 2003

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