Psychiatry Research
Volume 120, Issue 3 , Pages 211-218 , 15 October 2003

Increased levels of serum basic fibroblast growth factor in schizophrenia

  • Kenji Hashimoto

      Affiliations

    • Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba 260-8670, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-43-226-2147; fax: +81-43-226-2150
  • ,
  • Eiji Shimizu

      Affiliations

    • Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba 260-8670, Japan
  • ,
  • Naoya Komatsu

      Affiliations

    • Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba 260-8670, Japan
  • ,
  • Michiko Nakazato

      Affiliations

    • Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba 260-8670, Japan
  • ,
  • Naoe Okamura

      Affiliations

    • Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba 260-8670, Japan
  • ,
  • Hiroyuki Watanabe

      Affiliations

    • Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba 260-8670, Japan
  • ,
  • Chikara Kumakiri

      Affiliations

    • Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba 260-8670, Japan
  • ,
  • Naoyuki Shinoda

      Affiliations

    • Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba 260-8670, Japan
  • ,
  • Shin-ichi Okada

      Affiliations

    • Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba 260-8670, Japan
  • ,
  • Nori Takei

      Affiliations

    • Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    • Other affiliation for author is: Stanley Foundation Research Center in Japan, and Institute of Psychiatry, London, U.K.
  • ,
  • Masaomi Iyo

      Affiliations

    • Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba 260-8670, Japan

Received 10 October 2002 ,Revised 21 May 2003 ,Accepted 16 June 2003.

References 

  1. Altman DG. Practical Statistics for Medical Research. London: Chapman and Hall Publishers; 1991;
  2. Andreasen NC. Schizophrenia: the fundamental questions. Brain Research Review. 2000;31:106–112
  3. Buka SL, Tsuang MT, Torrey EF, Klebanoff MA, Wagner RL, Yolken RH. Maternal cytokine levels during pregnancy and adult psychosis. Brain, Behavior and Immunity. 2001;15:411–420
  4. Deguchi Y, Naito T, Yuge T, Furukawa A, Yamada S, Pardridge WM, et al. Blood–brain barrier transport of 125I-labeled basic fibroblast growth factor. Pharmaceutical Research. 2000;17:63–69
  5. Deguchi Y, Okutsu H, Okura T, Yamada S, Kimura R, Yuge T, et al. Internalization of basic fibroblast growth factor at the mouse blood–brain barrier involves perlecan, a heparan sulfate proteoglycan. Journal of Neurochemistry. 2002;83:381–389
  6. Ford-Perriss M, Abud H, Murphy M. Fibroblast growth factors in the developing central nervous system. Clinical and Experimental Pharmacology and Physiology. 2001;28:493–503
  7. Gremo F, Presta M. Role of fibroblast growth factor-2 in human brain: a focus on development. International Journal of Developmental Neuroscience. 2000;18:271–279
  8. Guy W. In: ECDEU Assessment Manual for Psychopharmacology Revised. Rockville, MD: National Institute of Mental Health; 1976;
  9. Howard, R., Rabins, P.V., Seeman, M.V., Jeste, D.V., International Late-Onset Schizophrenia Group, 2000. Late-onset schizophrenia and very-late-onset schizophrenia-like psychosis: an international consensus. American Journal of Psychiatry 157, 172–178
  10. Hyder SM, Stancel GM. Regulation of angiogenic growth factors in the female reproductive tract by estrogens and progestins. Molecular Endocrinology. 1999;13:806–811
  11. Joensuu H, Anttonen A, Eriksson M, Makitaro R, Alfthan H, Kinnula V, et al. Soluble syndecan-1 and serum basic fibroblast growth factor are new prognostic factors in lung cancer. Cancer Research. 2002;62:5210–5217
  12. Kronfol Z, Remick DG. Cytokines and the brain: implications for clinical psychiatry. American Journal of Psychiatry. 2000;157:683–694
  13. Kuhn HG, Winkler J, Kempermann G, Thal LJ, Gage FH. Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. Journal of Neuroscience. 1997;17:5820–5829
  14. Lewis DA, Lieberman JA. Catching up on schizophrenia: natural history and neurobiology. Neuron. 2000;28:325–334
  15. Lindamer LA, Lohr JB, Harris MJ, McAdams LA, Jeste DV. Gender-related clinical differences in older patients with schizophrenia. Journal of Clinical Psychiatry. 1999;60:61–67
  16. Molteni R, Fumagalli F, Magnaghi V, Roceri M, Gennarelli M, Racagni G, et al. Modulation of fibroblast growth factor-2 by stress and corticosteroids: from developmental events to adult brain plasticity. Brain Research Reviews. 2001;37:249–258
  17. Murray RM. Neurodevelopmental schizophrenia: the rediscovery of dementia praecox. British Journal of Psychiatry. 1994;165(suppl. 25):6–12
  18. Murray RM, O'Callaghan E, Castle DJ, Lewis SW. A neurodevelopmental approach to the classification of schizophrenia. Schizophrenia Research. 1992;18:319–332
  19. Pearlson GD. Neurobiology of schizophrenia. Annals of Neurology. 2000;48:556–566
  20. Raedler TJ, Knable MB, Weinberger DR. Schizophrenia as a developmental disorder of the cerebral cortex. Current Opinion in Neurobiology. 1998;8:157–161
  21. Riva MA, Molteni R, Tascedda F, Massironi A, Racagni G. Selective modulation of fibroblast growth factor-2 expression in the rat brain by the atypical antipsychotic clozapine. Neuropharmacology. 1999;38:1075–1082
  22. Salven P, Orpana A, Teerenhovi L, Joensuu H. Simultaneous elevation in the serum concentrations of the angiogenic growth factors VEGF and bFGF is an independent predictor of poor prognosis in non-Hodgkin lymphoma: a single-institution study of 200 patients. Blood. 2000;96:3712–3718
  23. Torrey EF, Yolken RH. The schizophrenia-rheumatoid arthritis connection: infectious, immune, or both. Brain, Behavior and Immunity. 2001;15:401–410
  24. Ugurel S, Rappl G, Tilgen W, Reinhold U. Increased serum concentration of angiogenic factors in malignant melanoma patients correlates with tumor progression and survival. Journal of Clinical Oncology. 2001;19:577–583
  25. Verdoux H, Geddes JR, Takei N, Lawrie SM, Bovert P, Eagles JM, et al. Obstetric complications and age at onset in schizophrenia: an international collaborative meta-analysis of individual patient data. American Journal of Psychiatry. 1997;154:1220–1227
  26. Wagner JP, Black IB, DiCicco-Bloom E. Stimulation of neonatal and adult brain neurogenesis by subcutaneous injection of basic fibroblast growth factor. Journal of Neuroscience. 1999;19:6006–6016
  27. Woods BT. Is schizophrenia a progressive neurodevelopmental disorder? Toward a unitary pathogenetic mechanism. American Journal of Psychiatry. 1998;155:1661–1670

PII: S0165-1781(03)00186-0

doi: 10.1016/S0165-1781(03)00186-0

Psychiatry Research
Volume 120, Issue 3 , Pages 211-218 , 15 October 2003