Detection of anti-Borna Disease Virus (BDV) antibodies from patients with schizophrenia and mood disorders in Japan

Terayama, Hayato; Nishino, Yoshii; Kishi, Masahiko; Ikuta, Kazuyoshi; Itoh, Masahiro; Iwahashi, Kazuhiko

doi:10.1016/S0165-1781(03)00190-2

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Volume 120, Issue 2 , Pages 201-206, 30 September 2003

Detection of anti-Borna Disease Virus (BDV) antibodies from patients with schizophrenia and mood disorders in Japan

Hayato Terayama
- Department of Neurophysiology, Graduate School of Azabu University, 1-71-1 Futinobe, Sagamihara-shi, Kanagawa 229-8501, Japan
Yoshii Nishino
- Research Institute of Biosciences, Azabu University, 1-71-1 Futinobe, Sagamihara-shi, Kanagawa 229-8501, Japan
Masahiko Kishi
- Tsukuba Central Laboratories, Kyoritsu Seiyaku Corporation, 2-9-22 Takamihara, Kukizaki-machi, Inashiki-gun, Ibaraki 300-1252, Japan
Kazuyoshi Ikuta
- Department of Virology Research, Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita-shi, Osaka 565-0871, Japan
Masahiro Itoh
- First Department of Anatomy, School of Tokyo Medical University 6-1-1 Sinjuku, Sinjuku-ku, Tokyo 160-8401, Japan
Kazuhiko Iwahashi
- Department of Neurophysiology, Graduate School of Azabu University, 1-71-1 Futinobe, Sagamihara-shi, Kanagawa 229-8501, Japan
- Health Administration Center, Azabu University, 1-71-1 Futinobe, Sagamihara-shi, Kanagawa 229-8501, Japan
- Corresponding author. Tel.: +81-42-769-1930; fax: +81-42-769-1930

Received 16 July 2001; received in revised form 29 January 2002; accepted 20 March 2002.

Abstract

The relationship between infection with the Borna Disease Virus (BDV) and the clinical symptoms of schizophrenia and mood disorders (DMS-IV) was investigated. Western blotting techniques were used to examine anti-p10-BDV antibodies in serum from 32 patients with schizophrenia and 33 patients with mood disorders in Japan. The results showed that 1 out of 25 controls (4.0%), 7 out of 32 patients with schizophrenia (21.9%) and 9 out of 33 patients with mood disorders (27.3%) were positive for anti-BDV-p10 antibodies. Compared with levels of anti- BDV-p10 antibodies in controls, the production of anti-BDV-p10 antibodies failed to show a statistically significant relationship with schizophrenia but did show a significant relationship with mood disorder. The subgroup of schizophrenia patients with positive syndromes had a non-significantly higher frequency of anti-BDV-p10 antibodies than the subgroup of patients with negative syndromes. Similarly, the production of anti-BDV-p10 antibodies was non-significantly higher among patients with the unipolar subtype of mood disorder than in those with the bipolar subtype.

Keywords: Anti-BDV-p10 antibody, Schizophrenia, Positive syndromes, Mood disorders, Unipolar types