Psychiatry Research
Volume 120, Issue 2 , Pages 201-206 , 30 September 2003

Detection of anti-Borna Disease Virus (BDV) antibodies from patients with schizophrenia and mood disorders in Japan

  • Hayato Terayama

      Affiliations

    • Department of Neurophysiology, Graduate School of Azabu University, 1-71-1 Futinobe, Sagamihara-shi, Kanagawa 229-8501, Japan
    • ,
  • Yoshii Nishino

      Affiliations

    • Research Institute of Biosciences, Azabu University, 1-71-1 Futinobe, Sagamihara-shi, Kanagawa 229-8501, Japan
    • ,
  • Masahiko Kishi

      Affiliations

    • Tsukuba Central Laboratories, Kyoritsu Seiyaku Corporation, 2-9-22 Takamihara, Kukizaki-machi, Inashiki-gun, Ibaraki 300-1252, Japan
    • ,
  • Kazuyoshi Ikuta

      Affiliations

    • Department of Virology Research, Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita-shi, Osaka 565-0871, Japan
    • ,
  • Masahiro Itoh

      Affiliations

    • First Department of Anatomy, School of Tokyo Medical University 6-1-1 Sinjuku, Sinjuku-ku, Tokyo 160-8401, Japan
    • ,
  • Kazuhiko Iwahashi

      Affiliations

    • Department of Neurophysiology, Graduate School of Azabu University, 1-71-1 Futinobe, Sagamihara-shi, Kanagawa 229-8501, Japan
    • Health Administration Center, Azabu University, 1-71-1 Futinobe, Sagamihara-shi, Kanagawa 229-8501, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-42-769-1930; fax: +81-42-769-1930

Received 16 July 2001 ,Revised 29 January 2002 ,Accepted 20 March 2002.

References 

  1. American Psychiatric Association, 1994. DSM-IV: Diagnostic and Statistical Manual of Mental Disorders. Author, Washington, DC
  2. Andreasen NC. Negative symptoms in schizophrenia definition and reliability. Archives of General Psychiatry. 1982;39:784–788
  3. Biler T, Stitz T. Immune-mediated brain atrophy: CD8+ T cells contribute to tissue destruction during Borna disease. Journal of Immunology. 1994;153:818
  4. Bode L. Human infection with Borna Disease Virus (BDV) and potential pathogenic implications. In:  Koprowski HL editors. Current Topics in Microbiology and Immunology. 190:1995;p. 103–130
  5. Bode L, Riegel S, Ludwig H, Amsterdam JD, Lange W, Koprowski H. Borna disease virus specific antibodies in patients with HIV infection and with mental disorders. Lancet. 1988;2(689):1988
  6. Bode L, Riegel S, Lange W. Human infections with Borna disease virus: seroprevalence in patients with chronic disease and healthy individuals. Journal of Medical Virology. 1992;36:309–315
  7. Bode L, Ferszt R, Czech G. Borna disease infection and affective disorders in man. Archives of Virology suppl. 1993;7:159–167
  8. Bode L, Durrwald R, Rantam FA, Ferszt R, Ludwig H. First isolates of infectious human Borna disease virus from patients with mood disorders. Molecular Psychiatry. 1996;1:200–212
  9. Carbone KM, Park SW, Rubin SA, Waltrip RW, Vogelsang GB. Borna disease: association with a maturation defect in the cellular immune response. Journal of Virology. 1991;65:6154–6164
  10. Crow TJ. Molecular pathology of schizophrenia: more than one disease process?. British Medical Journal. 1980;280:66–68
  11. Cubitt B, Oldstone C, de la Torre JC. Sequence and genome organization of Borna disease virus. Journal of Virology. 1994;68:1382–1396
  12. Day JC, Wood G, Dewey M, Bentall RP. A self-rating scale for measuring neuroleptic side-effects–validation in a group of schizophrenic patients. British Journal of Psychiatry. 1996;166:650–653
  13. de la Torre JC. Molecular biology of Borna disease virus: prototype of a new group of animal virus. Journal of Virology. 1994;68:7669–7675
  14. de la Torre JC, Gonzalez DD, Cubitt B, Mallory LA, Maslish E. Detection of Borna disease virus antigen and RNA in human autopsy brain sample from neuropsychiatric patients. Virology. 1996;223:272–282
  15. Ferszt R, Severus E, Bode L, Brehm M, Ludwig H. Activated Borna disease virus in affective disorders. Pharmacopsychiatry. 1999;32:93–98
  16. Fukuda K, Takahashi K, Iwata Y, Mori N, Gonda K, Ogawa T, et al. Immunological and PCR analyses for Borna disease virus in psychiatric patients and blood donors in Japan. Journal of Clinical Microbiology. 2001;39:419–429
  17. Gow J, Behan W, de la Torre JC, Dinan T, McGill M, Simpson K, et al. Borna disease virus and chronic fatigue syndrome. Journal of the Neurological Sciences. 1997;150:S225
  18. Hussin AA, Woldehiwet Z. Lymphocyte responses to viral antigens and phytohaemagglutinin in persistently viraemic sheep and lambs experimentally infected with Borna disease virus. Veterinary Microbiology. 1994;39:89–95
  19. Isoshima G, Iwahashi K, Ameno K, Nakamura K, Ikuta K. Detection of Borna disease virus RNA in autopsied brain samples of schizophrenia patients. Journal of Brain Science. 1998;24:73–80
  20. Iwahashi K, Watanabe M, Nakamura K, Suwaki H, Ikuta K. Clinical investigation of the relationship between Borna disease virus (BDV) infection and schizophrenia in 67 patients in Japan. Acta Psychiatrica Scandinavica. 1997;96:412–415
  21. Iwahashi K, Watanabe M, Nakamura K, Suwaki H, Nakaya T, Nakamura Y, et al. Positive and negative syndromes, and Borna disease virus infection in schizophrenia. Neuropsychobiology. 1998;32:59–64
  22. Kay SR, Fiszbein A, Opler LR. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin. 1987;13:261–276
  23. Kishi M, Nakaya T, Nakamura Y, Zhong Q, Ikeda K, Senjo M, et al. Demonstration of human Borna disease virus RNA in human peripheral blood mononuclear cells. FEBS Letter. 1995;364:293–297
  24. Kitani T, Kuratsune H, Fuke I, Nakamura Y, Nakaya T, Asahi S, et al. Possible correlation between Borna disease virus infection and Japanese patients with chronic fatigue syndrome. Microbiology and Immunology. 1996;40(6):459–462
  25. Ludwig H, Furuya K, Bode L, Klein N, Durrwald R, Lee DS. Biology and neurobiology of Borna disease virus (BDV), defined by antibodies, neutralizability and their pathogenic potential. Archives of Virology suppl. 1993;7:111–113
  26. Malik TH, Kishi M, Kobayashi T, Lai PK. Nuclear localization of the protein from the open reading frame ×1 of the Borna disease virus was through interactions with the viral nucleoprotein. Virology. 1999;258:65–72
  27. Nakaya T, Tanaka H, Nakamura Y, Asahi S, Tobiume M, Kuratsune H, et al. Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells derived from Japanese patient with chronic fatigue syndrome. FEBS Letter. 1996;378:145–149
  28. Nishino Y, Funaba M, Fukushima R, Mizutani T, Kimura T, Iizuka R, et al. Borna Disease Virus infection in domestic cats: evaluation by RNA and antibody detection. Journal of Veterinary Medical Science. 1999;61:1167–1170
  29. Richt JA, Herzog S, Preper J, Clements JE, Narayan O, Bechter K, et al. Borna disease virus: nature of the etiologic agent and significance of infection in man. Archives of Virology. 1993;suppl 7:101–109
  30. Rott R, Becht H. In:  Koprowski H,  Lipkin I editor. Borna Disease. Berlin: Springer Verlag KG; 1995;p. 17–30
  31. Schneeman A, Schnider PA, Lamb RA, Lipkin WI. The remarkable coding strategy of Borna disease virus: a new member of the non-sequenced negative strand RNA viruses. Virology. 1995;210:1–8
  32. Shanker V, Kao M, Hamir A, Sheng H, Koprowski H, Dietzschold B. Kinetics of virus spread and changes in levels of several cytokine mRNA in the brain after intranasal infection of rats with Borna disease virus. Journal of Virology. 1998;66:992–998
  33. Thorsten W, Rene P, Tatjana W, Jens R, Juergen AR. A short leucine–rich sequence in the Borna disease virus p10 protein mediates association with the viral phospho- and nucleoprotein. Journal of General Virology. 2000;81:939–947
  34. Waltrip RW, Buchanan RW, Carpenter WT, Kirkpatrick B, Summerfelt A, Breier A, et al. Borna disease virus antibodies and the deficit syndrome of schizophrenia. Schizophrenia Research. 1997;23:253–257
  35. Wehner T, Ruppert A, Herden C, Frese K, Becht H, Rich JA. Detection of a novel Borna disease virus-encoded 10 kDa protein in infected cells and tissues. Journal of General Virology. 1997;78:2459–2466
  36. Wimmer E, Hellen CU, Cao X. Genetics of poliovirus. Annual Review of Genetics. 1993;27:353–436

PII: S0165-1781(03)00190-2

doi: 10.1016/S0165-1781(03)00190-2

Psychiatry Research
Volume 120, Issue 2 , Pages 201-206 , 30 September 2003

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