Psychiatry Research
Volume 125, Issue 2 , Pages 87-93 , 15 February 2004

Alpha 2A adrenergic receptor gene and suicide

  • Adolfo Sequeira

      Affiliations

    • McGill Group for Suicide Studies, Douglas Hospital, McGill University, 6875 LaSalle Blvd., Verdun, QC, Canada H4H 1R3
  • ,
  • Firoza Mamdani

      Affiliations

    • McGill Group for Suicide Studies, Douglas Hospital, McGill University, 6875 LaSalle Blvd., Verdun, QC, Canada H4H 1R3
  • ,
  • Aleksandra Lalovic

      Affiliations

    • McGill Group for Suicide Studies, Douglas Hospital, McGill University, 6875 LaSalle Blvd., Verdun, QC, Canada H4H 1R3
  • ,
  • Milena Anguelova

      Affiliations

    • McGill Group for Suicide Studies, Douglas Hospital, McGill University, 6875 LaSalle Blvd., Verdun, QC, Canada H4H 1R3
  • ,
  • Alain Lesage

      Affiliations

    • Fernand Seguin Research Center, Université de Montréal, Montreal, Canada
  • ,
  • Monique Seguin

      Affiliations

    • McGill Group for Suicide Studies, Douglas Hospital, McGill University, 6875 LaSalle Blvd., Verdun, QC, Canada H4H 1R3
  • ,
  • Nadia Chawky

      Affiliations

    • McGill Group for Suicide Studies, Douglas Hospital, McGill University, 6875 LaSalle Blvd., Verdun, QC, Canada H4H 1R3
  • ,
  • Alex Desautels

      Affiliations

    • McGill Group for Suicide Studies, Douglas Hospital, McGill University, 6875 LaSalle Blvd., Verdun, QC, Canada H4H 1R3
  • ,
  • Gustavo Turecki

      Affiliations

    • McGill Group for Suicide Studies, Douglas Hospital, McGill University, 6875 LaSalle Blvd., Verdun, QC, Canada H4H 1R3
    • Corresponding Author InformationCorresponding author. Tel.: +1-514-7616131x2369; fax: +1-514-7623011

Received 14 February 2003 ,Revised 5 December 2003 ,Accepted 15 December 2003.

References 

  1. Bolonna AA, Arranz MJ, Munro J, Osborne S, Petouni M, Martinez M, et al. No influence of adrenergic receptor polymorphisms on schizophrenia and antipsychotic response. Neuroscience Letters. 2000;280:65–68
  2. Brent DA, Bridge J, Johnson BA, Connolly J. Suicidal behavior runs in families. A controlled family study of adolescent suicide victims. Archives of General Psychiatry. 1996;53:1145–1152
  3. Buss AH, Durkee A. An inventory for assessing different kinds of hostility. Journal of Consulting Psychology. 1957;21:343–349
  4. Callado LF, Meana JJ, Grijalba B, Pazos A, Sastre M, Garcia-Sevilla JA. Selective increase of alpha 2A-adrenoceptor agonist binding sites in brains of depressed suicide victims. Journal of Neurochemistry. 1998;70:1114–1123
  5. Cloninger, C.R., Przybeck T.R., Svrakic D.M., Wetzel R.D. 1994. The Temperament and Character Inventory (TCI): A Guide to Its Development and Use. Washington University, St. Louis, MO, pp. 1–148
  6. Cowburn RF, Marcusson JO, Eriksson A, Wiehager B, O'Neill C. Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims. Brain Research. 1994;633:297–304
  7. De Paermentier F, Mauger JM, Lowther S, Crompton MR, Katona CL, Horton RW. Brain alpha-adrenoceptors in depressed suicides. Brain Research. 1997;757:60–68
  8. Dwivedi Y, Conley RR, Roberts RC, Tamminga CA, Pandey GN. [3H]cAMP binding sites and protein kinase a activity in the prefrontal cortex of suicide victims. American Journal of Psychiatry. 2002;159:66–73
  9. Dwivedi Y, Rizavi HS, Roberts RC, Conley RC, Tamminga CA, Pandey GN. Reduced activation and expression of ERK1/2 MAP kinase in the post-mortem brain of depressed suicide subjects. Journal of Neurochemistry. 2001;77:916–928
  10. Feng J, Sobell JL, Heston LL, Goldman D, Cook E, Kranzler HR, et al. Variants in the alpha 2A AR adrenergic receptor gene in psychiatric patients. American Journal of Medical Genetics. 1998;81:405–410
  11. Garcia-Sevilla JA, Escriba PV, Ozaita A, La Harpe R, Walzer C, Eytan A, et al. Up-regulation of immunolabeled alpha2A-adrenoceptors, Gi coupling proteins, and regulatory receptor kinases in the prefrontal cortex of depressed suicides. Journal of Neurochemistry. 1999;72:282–291
  12. Glowinski AL, Bucholz KK, Nelson EC, Fu Q, Madden PA, Reich W, et al. Suicide attempts in an adolescent female twin sample. Journal of the American Academy of Child and Adolescent Psychiatry. 2001;40:1300–1307
  13. Gonzalez-Maeso J, Rodriguez-Puertas R, Meana JJ, Garcia-Sevilla JA, Guimon J. Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of α2A-adrenoceptors. Molecular Psychiatry. 2002;7:755–767
  14. Gonzalez AM, Pascual J, Meana JJ, Barturen F, del Arco C, Pazos A, et al. Autoradiographic demonstration of increased alpha 2-adrenoceptor agonist binding sites in the hippocampus and frontal cortex of depressed suicide victims. Journal of Neurochemistry. 1994;63:256–265
  15. Lindblad-Toh K, Winchester E, Daly MJ, Wang DG, Hirschhorn JN, Laviolette JP, et al. Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse. Nature Genetics. 2000;24:381–386
  16. Lowther S, Crompton RM, Katona CLE, Horton RW. GTPγS and forskolin-stimulated adenylyl cyclase activity in post-mortem brain from depressed suicides and controls. Molecular Psychiatry. 1996;1:470–477
  17. Meana JJ, Garcia-Sevilla JA. Increased alpha 2-adrenoceptor density in the frontal cortex of depressed suicide victims. Journal of Neural Transmission. 1987;70:377–381
  18. Mercier, G., Saint-Laurent, D., 1998. S'entraider pour la vie: Strategie Quebecoise d'Action Face au Suicide. Ministere de la Santé et del Services Sociaux, Quebec
  19. Newton CR, Graham A, Heptinstall LE, Powell SJ, Summers C, Kalsheker N, et al. Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS). Nucleic Acids Research. 1989;17:2503–2516
  20. Odagaki Y, Garcia-Sevilla JA, Huguelet P, La Harpe R, Koyama T, Guimon J. Cyclic AMP-mediated signaling components are upregulated in the prefrontal cortex of depressed suicide victims. Brain Research. 2001;898:224–231
  21. Ohara K, Nagai M, Tani K, Tsukamoto T, Suzuki Y, Ohara K. Polymorphism in the promoter region of the alpha 2A adrenergic receptor gene and mood disorders. Neuroreport. 1998;9:1291–1294
  22. Ohara K, Suzuki Y, Ochiai M, Terada H. Polymorphism in the promoter region of the alpha2A-adrenergic receptor gene and panic disorders. Psychiatry Research. 2000;93:79–82
  23. Patton JH, Stanford MS, Barratt ES. Factor structure of the Barratt Impulsiveness Scale. Journal of Clinical Psychology. 1995;51:768–774
  24. Roy A, Segal NL. Suicidal behavior in twins: a replication. Journal of Affective Disorders. 2001;66:71–74
  25. Roy A, Segal NL, Centerwall BS, Robinette CD. Suicide in twins. Archives of General Psychiatry. 1991;48:29–32
  26. Sambrook, J., Fritsch E.F., Maniatis T. 1989. Molecular Cloning. A Laboratory Manual, Cold Spring Harbor Laboratory Press, Plainview, NY
  27. Seguin, M., Turecki, G., Lesage, A., Tousignant, M., Chawky, N., Kim, C., Dewar, K., Brière, R., Lipp, O., Vanier, C., The Quebec Suicide and Grief Laboratory: a platform to investigate the multiple causes of suicide. Crisis, in press
  28. Simard LR, Prescott G, Rochette C, Morgan K, Lemieux B, Mathieu J, et al. Linkage disequilibrium analysis of childhood-onset spinal muscular atrophy (SMA) in the French–Canadian population. Human Molecular Genetics. 1994;3:459–463
  29. Small KM, Forbes SL, Brown KM, Liggett SB. An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling. Journal of Biological Chemistry. 2000;275:38518–38523
  30. Statham DJ, Heath AC, Madden PA, Bucholz KK, Bierut L, Dinwiddie SH, et al. Suicidal behavior: an epidemiological and genetic study. Psychological Medicine. 1998;28:839–855
  31. Tsai SJ, Wang YC, Hong CJ. Allelic variants of the alpha1a adrenoceptor and the promoter region of the alpha2a adrenoceptor and temperament factors. American Journal of Medical Genetics. 2001;105:96–98
  32. Turecki G. Suicidal behavior: is there a genetic predisposition?. Bipolar Disorders. 2001;3:335–349

PII: S0165-1781(03)00299-3

doi: 10.1016/j.psychres.2003.12.002

Psychiatry Research
Volume 125, Issue 2 , Pages 87-93 , 15 February 2004