Psychiatry Research
Volume 125, Issue 2 , Pages 95-104 , 15 February 2004

Mutation screening and association study of the beta-adrenergic receptor kinase 2 gene in schizophrenia families

  • Shun-Ying Yu

      Affiliations

    • Department of Neuropsychiatry, Nihon University, School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo, Japan 173-8610
    • Institute of Mental Health, Central South University, Changsha, Hunan, PR China 410011
    • ,
  • Sakae Takahashi

      Affiliations

    • Department of Neuropsychiatry, Nihon University, School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo, Japan 173-8610
    • Massachusetts Mental Health Center, Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    • ,
  • Tadao Arinami

      Affiliations

    • Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan 305-8575
    • ,
  • Tatsunobu Ohkubo

      Affiliations

    • Department of Neuropsychiatry, Nihon University, School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo, Japan 173-8610
    • ,
  • Yasundo Nemoto

      Affiliations

    • Department of Neuropsychiatry, Nihon University, School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo, Japan 173-8610
    • ,
  • Eiichi Tanabe

      Affiliations

    • Department of Neuropsychiatry, Nihon University, School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo, Japan 173-8610
    • ,
  • Yoichi Fukura

      Affiliations

    • Department of Neuropsychiatry, Nihon University, School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo, Japan 173-8610
    • ,
  • Masato Matsuura

      Affiliations

    • Department of Neuropsychiatry, Nihon University, School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo, Japan 173-8610
    • ,
  • Yong-Hua Han

      Affiliations

    • Institute of Mental Health, Beijing University, Beijing, PR China 100083
    • ,
  • Ru-Len Zhou

      Affiliations

    • Institute of Mental Health, Beijing University, Beijing, PR China 100083
    • ,
  • Yu-Cun Shen

      Affiliations

    • Institute of Mental Health, Beijing University, Beijing, PR China 100083
    • ,
  • Eisuke Matsushima

      Affiliations

    • Department of Neuropsychiatry, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan 113-8519
    • ,
  • Takuya Kojima

      Affiliations

    • Department of Neuropsychiatry, Nihon University, School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo, Japan 173-8610
    • Corresponding Author InformationCorresponding author. Tel.: +81-3-3972-8111x2431; fax: +81-3-3974-2920

Received 18 October 2002 ,Revised 30 October 2003 ,Accepted 15 December 2003.

References 

  1. American Psychiatric Association, 1994. DSM-IV: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. APA, Washington, DC
  2. Arriza JL, Dawson TM, Simerly RB, Martin LJ, Caron MG, Snyder SH, et al. The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain. Journal of Neuroscience. 1992;12:4045–4055
  3. Baron M. Genetics of schizophrenia and the new millennium: progress and pitfalls. American Journal of Human Genetics. 2001;68:299–312
  4. Barrett TB, Hauger RL, Kennedy JL, Sadovnick AD, Remick RA, Keck PE, et al. Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder. Molecular Psychiatry. 2003;8:546–557
  5. Dudbridge F, Koeleman BP, Todd JA, Clayton DG. Unbiased application of the transmission/disequilibrium test to multilocus haplotypes. American Journal of Human Genetics. 2000;66:2009–2012
  6. Garcia-Sevilla JA, Escribaa PV, Ozaita A, LaHarpe R, Walzer C, Eytan A, et al. Up-regulation of immunolabeled α-2A-adrenoceptors, Gi coupling proteins, and regulatory receptor kinases in the prefrontal cortex of depressed suicides. Journal of Neurochemistry. 1999;72:282–291
  7. Gottesman II, Bertelsen A. Confirming unexpressed genotypes for schizophrenia: risks in the offspring of Fischer's Danish identical and fraternal discordant twins. Archives of General Psychiatry. 1989;46:867–872
  8. Halushka MK, Fan JB, Bentley K, Hsie L, Shen N, Weder A, et al. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nature Genetics. 1999;22:239–247
  9. Hauger RL, Smith RD, Braun S, Dautzenberg FM, Catt KJ. Rapid agonist-induced phosphorylation of the human CRF receptor, type 1: a potential mechanism for homologous desensitization. Biochemical and Biophysical Research Communications. 2000;268:572–576
  10. Kendler KS, Diehl SR. The genetics of schizophrenia: a current, genetic–epidemiologic perspective. Schizophrenia Bulletin. 1993;19:261–285
  11. Kety SS. Schizophrenic illness in the families of schizophrenic adoptees: findings from the Danish national sample. Schizophrenia Bulletin. 1988;14:217–222
  12. Kojima T, Matsushima E, Ando H. Exploratory eye movements and neuropsychological tests in schizophrenic patients. Schizophrenia Bulletin. 1992;18:85–94
  13. Kojima T, Matsushima E, Ohta K, Toru M, Han YH, Shen YC, et al. Stability of exploratory eye movements as a marker of schizophrenia—a WHO multi-center study. Schizophrenia Research. 2001;52:203–214
  14. Liu H, Heath SC, Sobin C, Roos JL, Galke BL, Blundell ML, et al. Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 2002;99:3717–3722
  15. Matsushima E, Kojima T, Ohta K, Obayashi S, Nakajima K, Kakuma T, et al. Exploratory eye movement dysfunctions in patients with schizophrenia: possibility as a discriminator for schizophrenia. Journal of Psychiatric Research. 1998;32:289–295
  16. McGuffin P, Owen MJ, Farmer AE. Genetic basis of schizophrenia. Lancet. 1995;346(8976):678–682
  17. Myles-Worsley M, Coon H, McDowell J, Brenner C, Hoff M, Lind B, et al. Linkage of a composite inhibitory phenotype to a chromosome 22q locus in eight Utah families. American Journal of Medical Genetics. 1999;88:544–550
  18. Niculescu AB, Segal DS, Kuczenski R, Barrett T, Hauger RL, Kelsoe JR. Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach. Physiological Genomics. 2000;4:83–91
  19. Pitcher JA, Freedman NJ, Lefkowitz RJ. G protein-coupled receptor kinases. Annual Review of Biochemistry. 1998;67:653–692
  20. Pulver AE. Search for schizophrenia susceptibility genes. Biological Psychiatry. 2000;47:221–230
  21. Riley BP, McGuffin P. Linkage and associated studies of schizophrenia. American Journal of Medical Genetics. 2000;97:23–44
  22. Takahashi S, Ohtsuki T, Yu SY, Tanabe E, Yara K, Kamioka M, et al. Significant linkage to chromosome 22q for exploratory eye movement dysfunction in schizophrenia. American Journal of Medical Genetics. 2003;123B:27–32
  23. Tiberi M, Nash SR, Bertrand L, Lefkowitz RJ, Caron MG. Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases. Journal of Biological Chemistry. 1996;271:3771–3778

PII: S0165-1781(03)00300-7

doi: 10.1016/j.psychres.2003.12.003

Psychiatry Research
Volume 125, Issue 2 , Pages 95-104 , 15 February 2004

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