Psychiatry Research
Volume 125, Issue 2 , Pages 147-160 , 15 February 2004

Exploration of somatosensory P50 gating in schizophrenia spectrum patients: reduced P50 amplitude correlates to social anhedonia

  • Sidse M. Arnfred

      Affiliations

    • Department of Psychiatry, Hvidovre Hospital, University Hospital of Copenhagen, Brøndbyøstervej 160, DK-2605 Brøndby, Denmark
    • Corresponding Author InformationCorresponding author. Present address: Bispebjerg Bakke 23, Copenhagen NV, Denmark. Tel.: +45-35-31-26-61/+45-24-62-75-12; fax: +45-35-31-39-53
  • ,
  • Andrew C.N. Chen

      Affiliations

    • Human Brain Mapping and Cortical Imaging Laboratory, Aalborg University, DK-9220 Aalborg, Denmark

Received 27 May 2003 ,Revised 30 September 2003 ,Accepted 16 December 2003.

References 

  1. Adler LE, Pachtman E, Franks RD, Pecevich M, Waldo MC, Freedman R. Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia. Biological Psychiatry. 1982;17:639–654
  2. Allen JE, Jenner A, Stevens JC. Early cortical tactile-evoked potentials, laterality and schizophrenia. British Journal of Psychiatry. 1991;158:529–533
  3. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: APA; 1994;
  4. Andreasen N. Scale for the Assessment of Negative Symptoms (SANS). Iowa City: University of Iowa; 1984;
  5. Andreasen N. Scale for the Assessment of Positive Symptoms (SAPS). Iowa City: University of Iowa; 1984;
  6. Andreasen NC. The Scale for the Assessment of Negative Symptoms (SANS): conceptual and theoretical foundations. British Journal of Psychiatry. 1989;(Nov. (7)):49–58
  7. Arnfred SM, Chen AC, Eder DN, Glenthoj BY, Hemmingsen RP. A mixed modality paradigm for recording somatosensory and auditory P50 gating. Psychiatry Research. 2001;105:79–86
  8. Arnfred SM, Chen ACN, Glenthoj BY, Hemmingsen RP. Normal P50 gating in unmedicated schizophrenia outpatients. American Journal of Psychiatry. 2003;60:2236–2238
  9. Arnfred SM, Eder DN, Hemmingsen RP, Glenthoj BY, Chen AC. Gating of the vertex somatosensory and auditory evoked potential P50 and the correlation to skin conductance orienting response in healthy men. Psychiatry Research. 2001;101:221–235
  10. Braff DL. Information processing and attention dysfunctions in schizophrenia. Schizophrenia Bulletin. 1993;19:233–259
  11. Buchsbaum MS. The middle evoked response components and schizophrenia. Schizophrenia Bulletin. 1977;3:93–104
  12. Cardenas VA, Gerson J, Fein G. The reliability of P50 suppression as measured by the conditioning/testing ratio is vastly improved by dipole modeling. Biological Psychiatry. 1993;33:335–344
  13. Chapman LJ, Chapman JP, Raulin ML. Scales for physical and social anhedonia. Journal of Abnormal Psychology. 1976;85:374–382
  14. Chiappa, K.H. (Ed.), 1997. Principles of Evoked Potentials. Evoked Potentials in Clinical Medicine. Lippincott-Raven Publishers, Philadelphia
  15. Clementz BA, Blumenfeld LD. Multichannel electroencephalographic assessment of auditory evoked response suppression in schizophrenia. Experimental Brain Research. 2001;139:377–390
  16. Cooper JE, Andrews H, Barber C. Stable abnormalities in the lateralisation of early cortical somatosensory evoked potentials in schizophrenic patients. British Journal of Psychiatry. 1985;146:585–593
  17. Desmedt JE, Bourguet M, Nguyen Tran H, Delacuvellerie M. The P40 and P100 processing positivities that precede P300 closure in serial somatosensory decision tasks. Annals of the New York Academy of Sciences. 1984;425:188–193
  18. Desmedt JE, Huy NT, Bourguet M. The cognitive P40, N60 and P100 components of somatosensory evoked potentials and the earliest electrical signs of sensory processing in man. Electroencephalography and Clinical Neurophysiology. 1983;56:272–282
  19. Desmedt JE, Tomberg C. Mapping early somatosensory evoked potentials in selective attention: critical evaluation of control conditions used for titrating by difference the cognitive P30, P40, P100 and N140. Electroencephalography and Clinical Neurophysiology. 1989;74:321–346
  20. Eckblad ML, Chapman LJ, Chapman JP, Mishlove M. The Revised Social Anhedonia Scale. Madison: University of Wisconsin; 1982;
  21. Freedman R, Adler LE, Gerhardt GA, Waldo M, Baker N, Rose GM, et al. Neurobiological studies of sensory gating in schizophrenia. Schizophrenia Bulletin. 1987;13:669–678
  22. Freedman R, Adler LE, Waldo MC, Pachtman E, Franks RD. Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia: comparison of medicated and drug-free patients. Biological Psychiatry. 1983;18:537–551
  23. Furlong P, Barczak P, Hayes G, Harding G. Somatosensory evoked potentials in schizophrenia. A lateralisation study. British Journal of Psychiatry. 1990;157:881–887
  24. Garcia-Larrea L, Lukaszewicz AC, Mauguiere F. Somatosensory responses during selective spatial attention: The N120-to-N140 transition. Psychophysiology. 1995;32:526–537
  25. Ghisolfi ES, Prokopiuk AS, Becker J, Ehlers JA, Belmonte-de-Abreu P, Souza DO, et al. The adenosine antagonist theophylline impairs P50 auditory sensory gating in normal subjects. Neuropsychopharmacology. 2002;27:629–637
  26. Gooding DC, Davidson RJ, Putnam KM, Tallent KA. Normative emotion-modulated startle response in individuals at risk for schizophrenia-spectrum disorders. Schizophrenia Research. 2002;57:109–120
  27. Gray JA. Integrating schizophrenia. Schizophrenia Bulletin. 1998;24:249–266
  28. Gruzelier J, Raine A. Bilateral electrodermal activity and cerebral mechanisms in syndromes of schizophrenia and the schizotypal personality. International Journal of Psychophysiology. 1994;16:1–16
  29. Hemsley DR. Schizophrenia. A cognitive model and its implications for psychological intervention. Behavioural Modification. 1996;20:139–169
  30. Jin Y, Bunney WE, Sandman CA, Patterson JV, Fleming K, Moenter JR, et al. Is P50 suppression a measure of sensory gating in schizophrenia?. Biological Psychiatry. 1998;43:873–878
  31. Jin Y, Potkin SG. P50 changes with visual interference in normal subjects: a sensory distraction model for schizophrenia. Clinical Electroencephalography. 1996;27:151–154
  32. Jin Y, Potkin SG, Patterson JV, Sandman CA, Hetrick WP, Bunney WE. Effects of P50 temporal variability on sensory gating in schizophrenia. Psychiatry Research. 1997;70:71–81
  33. Josiassen RC, Shagass C, Roemer RA, Slepner S, Czartorysky B. Early cognitive components of somatosensory event-related potentials. International Journal of Psychophysiology. 1990;9:139–149
  34. Judd LL, McAdams L, Budnick B, Braff DL. Sensory gating deficits in schizophrenia: new results. American Journal of Psychiatry. 1992;149:488–493
  35. Kekoni J, Hamalainen H, Saarinen M, Grohn J, Reinikainen K, Lehtokoski A, et al. Rate effect and mismatch responses in the somatosensory system: ERP-recordings in humans. Biological Psychology. 1997;46:125–142
  36. McGhie A, Chapman JS. Disorders of attention and perception in early schizophrenia. British Journal of Medical Psychology. 1961;34:103
  37. McLaughlin DF, Kelly EF. Evoked potentials as indices of adaptation in the somatosensory system in humans: a review and prospectus. Brain Research Brain Research Reviews. 1993;18:151–206
  38. Nagamoto HT, Adler LE, Waldo MC, Freedman R. Sensory gating in schizophrenics and normal controls: effects of changing stimulation interval. Biological Psychiatry. 1989;25:549–561
  39. Patterson JV, Jin Y, Gierczak M, Hetrick WP, Potkin S, Bunney WE, et al. Effects of temporal variability on P50 and the gating ratio in schizophrenia: a frequency domain adaptive filter single-trial analysis. Archives of General Psychiatry. 2000;57:57–64
  40. Picton TW, Hillyard SA, Krausz HI, Galambos R. Human auditory evoked potentials. I. Evaluation of components. Electroencephalography and Clinical Neurophysiology. 1974;36(2):179–190
  41. Rado S. Dynamics and classification of disordered behavior. American Journal of Psychiatry. 1953;110:406–426
  42. Roemer RA, Shagass C, Straumanis JJ, Amadeo M. Somatosensory and auditory evoked potential studies of functional differences between the cerebral hemispheres in psychosis. Biological Psychiatry. 1979;14:357–373
  43. Shagass C. An electrophysiological view of schizophrenia. Biological Psychiatry. 1976;11:3–30
  44. Shagass C. Early evoked potentials. Schizophrenia Bulletin. 1977;3:80–92
  45. Shagass C, Josiassen RC, Roemer RA, Straumanis JJ, Slepner SM. Failure to replicate evoked potential observations suggesting corpus callosum dysfunction in schizophrenia. British Journal of Psychiatry. 1983;142:471–476
  46. Shagass C, Roemer RA, Straumanis JJ, Amadeo M. Evoked potential correlates of psychosis. Biological Psychiatry. 1978;13:163–184
  47. Shagass C, Roemer RA, Straumanis JJ, Amadeo M. Temporal variability of somatosensory, visual, and auditory evoked potentials in schizophrenia. Archives of General Psychiatry. 1979;36:1341–1351
  48. Shagass C, Straumanis JJ, Roemer RA, Amadeo M. Evoked potentials of schizophrenics in several sensory modalities. Biological Psychiatry. 1977;12:221–235
  49. Shakow D. The Worcester State Hospital research on schizophrenia (1927–1946). Psychological Issues. 1977;10:208–315
  50. Smith DA, Boutros NN, Schwarzkopf SB. Reliability of P50 auditory event-related potential indices of sensory gating. Psychophysiology. 1994;31:495–502
  51. Stevens JC. Somatosensory evoked potentials. In:  Daube JR editors. Clinical Neurophysiology. Oxford: Oxford University Press; 2002;
  52. Tress KH, Caudrey DJ, Mehta B. Tactile-evoked potentials in schizophrenia. Interhemispheric transfer and drug effects. British Journal of Psychiatry. 1983;143:156–164
  53. White PM, Yee CM. Effects of attentional and stressor manipulations on the P50 gating response. Psychophysiology. 1997;34:703–711
  54. Wing JK, Babor T, Brugha T, Burke J, Cooper JE, Giel R, et al. SCAN. Schedules for Clinical Assessment in Neuropsychiatry. Archives of General Psychiatry. 1990;47:589–593
  55. Wing, J.K., Sartorius, N., Ûstün, T.B. (Eds.), 1998. Diagnosis and Clinical Measurement in Psychiatry. A Reference Manual for SCAN. Cambridge University Press, Cambridge, U.K

PII: S0165-1781(03)00305-6

doi: 10.1016/j.psychres.2003.12.008

Psychiatry Research
Volume 125, Issue 2 , Pages 147-160 , 15 February 2004