Accelerated age-related decline of visual information processing in first-degree relatives of persons with schizophrenia

Abstract 

A recent cross-sectional study suggested that persons with schizophrenia experience an accelerated age-related decline in performance on the Span of Apprehension task, a visual information processing paradigm. However, this study was not able to determine if such decline was primarily related to genetic loading for schizophrenia, as the decline may have been related to chronic neuroleptic use or other confounds found when studying persons with schizophrenia directly. To help address this question, the current study examined healthy first-degree relatives of persons with schizophrenia over a wide age range to investigate whether such age effects may be related to genetic loading for schizophrenia. Twenty-eight healthy first-degree relatives of persons with schizophrenia (ages 21–72) and 31 healthy controls (ages 19–75) were evaluated using the Span of Apprehension task with cross-sectional methodology. Results replicated and extended the earlier report examining persons with schizophrenia, as the data indicated a statistically significant accelerated age-related decline in performance in the relatives. While the study is limited by cross-sectional methodology, it suggests a genetically driven, age-related decline in visual information processing related to schizophrenia and informs future longitudinal studies that can more definitively address such a possibility.

Keywords: Genetics, Span of Apprehension task, Schizophrenia, Age