Psychiatry Research
Volume 129, Issue 2 , Pages 141-147 , 15 December 2004

Subjective quality of life in first episode schizophrenia spectrum disorders with comorbid depression

  • Kang Sim

      Affiliations

    • Department of Early Psychosis Intervention, Woodbridge Hospital/Institute of Mental Health, 10, Buangkok View, Singapore 539747, Singapore
    • Department of Adult Psychiatry, Woodbridge Hospital/Institute of Mental Health, Singapore
    • Schizophrenia and Bipolar Disorders Program, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    • Corresponding Author InformationCorresponding author. Department of Early Psychosis Intervention, Woodbridge Hospital/Institute of Mental Health, 10, Buangkok View, Singapore 539747, Singapore. Tel.: +65 63892000; fax: +65 63855900.
    • ,
  • Rathi Mahendran

      Affiliations

    • Department of Adult Psychiatry, Woodbridge Hospital/Institute of Mental Health, Singapore
    • ,
  • Samuel G. Siris

      Affiliations

    • Department of Psychiatry, Hillside Hospital Division of the North Shore, Long Island Jewish Health System and The Albert Einstein College of Medicine, New York, NY, USA
    • ,
  • Stephan Heckers

      Affiliations

    • Schizophrenia and Bipolar Disorders Program, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    • ,
  • Siow Ann Chong

      Affiliations

    • Department of Early Psychosis Intervention, Woodbridge Hospital/Institute of Mental Health, 10, Buangkok View, Singapore 539747, Singapore

Received 8 February 2004 ,Revised 13 July 2004 ,Accepted 26 July 2004.

References 

  1. Addington D, Addington J, Patten S. Gender and affect in schizophrenia. Canadian Journal of Psychiatry. 1996;41:265–268
  2. Amador XF, Flaum M, Andreasen NC, Strauss DH, Yale SA, Clark SC, et al. Awareness of illness in schizophrenia and schizoaffective and mood disorders. Archives of General Psychiatry. 1994;51:826–836
  3. Barry MM, Zissi A. Quality of life as an outcome measure in evaluating mental health services: a review of the empirical evidence. Social Psychiatry and Psychiatric Epidemiology. 1997;32:38–47
  4. Bow-Thomas CC, Velligan DI, Miller AL, Olsen J. Predicting quality of life from symptomatology in schizophrenia at exacerbation and stabilization. Psychiatry Research. 1999;86:131–142
  5. Brekke JS, Kohrt B, Green MF. Neuropsychological functioning as a moderator of the relationship between psychosocial functioning and the subjective experience of self and life in schizophrenia. Schizophrenia Bulletin. 2001;27:697–708
  6. Browne S, Clarke M, Gervin M, Waddington JL, Larkin C, O'Callaghan E. Determinants of quality of life at first presentation with schizophrenia. British Journal of Psychiatry. 2000;176:173–176
  7. Dixon L, Goldberg R, Lehman A, McNary S. The impact of health status on work, symptoms, and functional outcomes in severe mental illness. Journal of Nervous and Mental Disease. 2001;189:17–23
  8. First, M.B., Spitzer, R.L., Gibbon, M., 1994. Structured Clinical Interview for DSM IV Axis I Disorders, Patient Edition (SCID-P), version 2. New York State Psychiatric Institute, Biometrics Research, New York.
  9. Guyatt GH, Feeny DH, Patrick DL. Measuring health-related quality of life. Annals of Internal Medicine. 1993;118:622–629
  10. Hamilton M. A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry. 1960;23:56–61
  11. Herrman H, Hawthorne G, Thomas R. Quality of life assessment in people living with psychosis. Social Psychiatry and Psychiatric Epidemiology. 2002;37:510–518
  12. Ho BC, Nopoulos P, Flaum M, Arndt S, Andreasen NC. Two-year outcome in first-episode schizophrenia: predictive value of symptoms for quality of life. American Journal of Psychiatry. 1998;155:1196–1201
  13. Ho BC, Andreasen NC, Flaum M, Nopoulos P, Miller D. Untreated initial psychosis: its relation to quality of life and symptom remission in first-episode schizophrenia. American Journal of Psychiatry. 2000;157:808–815
  14. House A, Bostock J, Cooper J. Depressive syndromes in the year following onset of a first schizophrenic illness. British Journal of Psychiatry. 1987;151:773–779
  15. Huppert JD, Weiss KA, Lim R, Pratt S, Smith TE. Quality of life in schizophrenia: contributions of anxiety and depression. Schizophrenia Research. 2001;51:171–180
  16. Kay SR, Fiszbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin. 1987;13:261–276
  17. Kessler RC, McGonagle KA, Swartz M, Blazer DG, Nelson CB. Sex and depression in the National Comorbidity Survey: I. Lifetime prevalence, chronicity and recurrence. Journal of Affective Disorders. 1993;29:85–96
  18. Koreen AR, Siris SG, Chakos M, Alvir J, Mayerhoff D, Lieberman J. Depression in first-episode schizophrenia. American Journal of Psychiatry. 1993;150:1643–1648
  19. Lehman AF. Measures of quality of life among persons with severe and persistent mental disorders. Social Psychiatry and Psychiatric Epidemiology. 1996;31:78–88
  20. Mechanic D, McAlpine D, Rosenfield S, David D. Effects of illness attribution and depression on the quality of life among persons with serious mental illness. Social Science & Medicine. 1994;39:155–164
  21. Ritsner M, Modai I, Endicott J, Rivkin O, Nechamkin Y, Barak P, et al. Differences in quality of life domains and psychopathologic and psychosocial factors in psychiatric patients. Journal of Clinical Psychiatry. 2000;61:880–889
  22. Sands JR, Harrow M. Depression during the longitudinal course of schizophrenia. Schizophrenia Bulletin. 1999;25:157–171
  23. Saxena S, Carlson D, Billington R. The WHO quality of life assessment instrument (WHOQOL-Bref): the importance of its items for cross-cultural research. Quality of Life Research. 2001;10:711–721
  24. Schulze B, Angermeyer MC. Subjective experiences of stigma. A focus group study of schizophrenic patients, their relatives and mental health professionals. Social Science & Medicine. 2003;56:299–312
  25. Shmueli A. Socio-economic and demographic variation in health and in its measures: the issue of reporting heterogeneity. Social Science & Medicine. 2003;57:125–134
  26. Shtasel DL, Gur RE, Gallacher F, Heimberg C, Gur RC. Gender differences in the clinical expression of schizophrenia. Schizophrenia Research. 1992;7:225–231
  27. Siris SG. Suicide and schizophrenia. Journal of Psychopharmacology. 2001;15:129–137
  28. Siris SG, Bench C. Depression and schizophrenia. In:  Hirsch SR,  Weinberger DR editor. Schizophrenia. Oxford: Blackwell Publishing; 2003;p. 142–167
  29. Subotnik KL, Nuechterlein KH, Asarnow RF, Fogelson DL, Goldstein MJ, Talovic SA. Depressive symptoms in the early course of schizophrenia: relationship to familial psychiatric illness. American Journal of Psychiatry. 1997;154:1551–1556
  30. Swanson CL, Gur RC, Bilker W, Petty RG, Gur RE. Premorbid educational attainment in schizophrenia: association with symptoms, functioning, and neurobehavioral measures. Biological Psychiatry. 1998;44:739–747
  31. Tek C, Kirkpatrick B, Buchanan RW. A five-year followup study of deficit and nondeficit schizophrenia. Schizophrenia Research. 2001;49:253–260
  32. Testa MA, Simonson DC. Assessment of quality-of-life outcomes. New England Journal of Medicine. 1996;334:835–840
  33. The WHOQOL Group. Development of the World Health Organization WHOQOL-BREF quality of life assessment. Psychological Medicine. 1998;28:551–558
  34. Wassink TH, Flaum M, Nopoulos P, Andreasen NC. Prevalence of depressive symptoms early in the course of schizophrenia. American Journal of Psychiatry. 1999;156:315–316
  35. Wilson IB, Cleary PD. Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. Journal of American Medical Association. 1995;273:59–65
  36. Yao G, Chung CW, Yu CF, Wang JD. Development and verification of validity and reliability of the WHOQOL-BREF Taiwan version. Journal of Formosa Medical Association. 2002;101:342–351

PII: S0165-1781(04)00203-3

doi: 10.1016/j.psychres.2004.07.007

Psychiatry Research
Volume 129, Issue 2 , Pages 141-147 , 15 December 2004

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