Psychiatry Research
Volume 133, Issue 1 , Pages 91-99 , 30 January 2005

Decision-making impairments in patients with pathological gambling

  • Matthias Brand

      Affiliations

    • Department of Physiological Psychology, University of Bielefeld, P.O. Box 100131, 33501 Bielefeld, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 521 1064488; fax: +49 521 1066049.
    • ,
  • Elke Kalbe

      Affiliations

    • Max-Planck-Institute for Neurological Research, Gleuelerstr. 50, 50931 Cologne, Germany
    • ,
  • Kirsten Labudda

      Affiliations

    • Department of Physiological Psychology, University of Bielefeld, P.O. Box 100131, 33501 Bielefeld, Germany
    • ,
  • Esther Fujiwara

      Affiliations

    • Department of Physiological Psychology, University of Bielefeld, P.O. Box 100131, 33501 Bielefeld, Germany
    • ,
  • Josef Kessler

      Affiliations

    • Max-Planck-Institute for Neurological Research, Gleuelerstr. 50, 50931 Cologne, Germany
    • ,
  • Hans J. Markowitsch

      Affiliations

    • Department of Physiological Psychology, University of Bielefeld, P.O. Box 100131, 33501 Bielefeld, Germany

Received 9 December 2003 ,Revised 13 September 2004 ,Accepted 15 October 2004.

References 

  1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: Author; 1994;
  2. Apkarian AV, Sosa Y, Krauss BR, Thomas PS, Fredrickson BE, Levy RE, et al. Chronic pain patients are impaired on an emotional decision-making task. Pain. 2004;108:129–136
  3. Bäumler G. Farbe-Wort-Interferenztest (FWIT). Göttingen: Hogrefe; 1985;
  4. Bechara A. Neurobiology of decision-making: risk and reward. Seminars in Clinical Neuropsychiatry. 2001;6:205–216
  5. Bechara A, Damasio H. Decision-making and addiction (part I): impaired activation of somatic states in substance dependent individuals when pondering decision with negative future consequences. Neuropsychologia. 2002;40:1675–1689
  6. Bechara A, Martin EM. Impaired decision making related to working memory deficits in individuals with substance addictions. Neuropsychology. 2004;18:152–162
  7. Bechara A, Damasio AR, Damasio H, Anderson SW. Insensitivity to future consequences following damage to human prefrontal cortex. Cognition. 1994;50:7–15
  8. Bechara A, Damasio H, Tranel D, Anderson SW. Dissociation of working memory from decision making within the human prefrontal cortex. Journal of Neuroscience. 1998;18:428–437
  9. Bechara A, Tranel D, Damasio H. Characterization of decision-making deficit of patients with ventromedial prefrontal cortex lesions. Brain. 2000;123:2189–2202
  10. Bechara A, Dolan S, Denburg N, Hindes A, Anderson SW, Nathan PE. Decision-making deficits, linked to dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers. Neuropsychologia. 2001;39:376–389
  11. Bechara A, Dolan S, Hindes A. Decision-making and addiction (part II): myopia for the future or hypersensitivity to reward?. Neuropsychologia. 2002;40:1690–1705
  12. Brand, M., Fujiwara, E., Borsutzky, S., Kalbe, E., Kessler, J., Markowitsch, H.J., 2005a. Decision-making deficits of Korsakoff patients in a new gambling task with explicit rules—associations with executive functions. Neuropsychology (in press).
  13. Brand, M., Labudda, K., Kalbe, E., Hilker, R., Emmans, D., Fuchs, G., Kessler, J., Markowitsch, H.J., 2005b. Decision-making impairments in patients with Parkinson's disease. Behavioural Neurology (in press).
  14. Cavedini P, Riboldi G, D'Annucci A, Belotti P, Cisima M, Bellodi L. Decision-making heterogenity in obsessive-compulsive disorder: ventromedial prefrontal cortex function predicts different treatment outcomes. Neuropsychologia. 2002;40:205–211
  15. Cavedini P, Riboldi G, Keller R, D'Annucci A, Bellodi L. Frontal lobe dysfunction in pathological gambling patients. Biological Psychiatry. 2002;51:334–341
  16. Cavedini P, Bassi T, Ubbiali A, Casolari A, Giordani S, Zorzi C, et al. Neuropsychological investigation of decision-making in anorexia nervosa. Psychiatry Research. 2004;127:259–266
  17. Cloninger CR. A systematic method for clinical description and classification of personality variants. A proposal. Archives of General Psychiatry. 1987;44:573–588
  18. Crone EA, van der Molen MW. Developmental changes in real life decision making: performance on a gambling task previously shown to depend on the ventromedial prefrontal cortex. Developmental Neuropsychology. 2004;25:251–279
  19. Damasio AR. The somatic marker hypothesis and the possible functions of prefrontal cortex. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 1996;351:1413–1420
  20. Fahrenberg J, Hampel R, Selg H. Das Freiburger Persönlichkeitsinventar (FPI-R). Göttingen: Hogrefe; 2001;
  21. Fellows LK, Farah MJ. Different underlying impairments in decision-making following ventromedial and dorsolateral frontal lobe damage in humans. Cerebral Cortex. 2005;15:58–63
  22. Kessler J, Calabrese P, Kalbe E, Berger F. DemTect: Ein neues Screening-Verfahren zur Unterstützung der Demenzdiagnostik. Psycho. 2000;26:343–347
  23. Kim SW, Grant JE. Personality dimensions in pathological gambling disorder and obsessive-compulsive disorder. Psychiatry Research. 2001;104:205–212
  24. Lineweaver TT, Bondi MW, Thomas RG, Salmon DP. A normative study of Nelson's (1976) modified version of the Wisconsin Card Sorting Test in healthy older adults. Clinical Neuropsychologist. 1999;13:328–347
  25. Manes F, Sahakian B, Clark L, Rogers R, Antoun N, Aitken M, et al. Decision-making processes following damage to the prefrontal cortex. Brain. 2002;125:624–639
  26. Nelson HE. A modified card sorting test sensitive to frontal lobe defects. Cortex. 1976;12:313–324
  27. Ostendorf F, Angleitner A. NEO-Persönlichkeitsinventar nach Costa und McCrae, revidierte form (NEO-PI-R). Göttingen: Hogrefe; 2003;
  28. Potenza MN, Steinberg MA, Skudlarski P, Fulbright RK, Lacadie CM, Wilber MK, et al. Gambling urges in pathological gambling: a functional magnetic resonance imaging study. Archives of General Psychiatry. 2003;60:828–836
  29. Ritter LM, Meador-Woodruff JH, Dalack GW. Neurocognitive measures of prefrontal cortical dysfunction in schizophrenia. Schizophrenia Research. 2004;68:65–73
  30. Rotheram-Fuller E, Shoptaw S, Berman SM, London ED. Impaired performance in a test of decision-making by opiate-dependent tobacco smokers. Drug and Alcohol Dependence. 2004;73:79–86
  31. Rugle L, Melamed L. Neuropsychological assessment of attention problems in pathological gamblers. Journal of Nervous and Mental Disease. 1993;181:107–112
  32. Specker SM, Carlson GA, Christenson GA, Marcotte M. Impulse control disorders and attention deficit disorder in pathological gamblers. Annals of Clinical Psychiatry. 1995;7:175–179
  33. Spreen O, Strauss E. A Compendium of Neuropsychological Tests. New York: Oxford University Press; 1998;
  34. Stout JC, Rodawalt WC, Siemers ER. Risky decision making in Huntington's disease. Journal of the International Neuropsychological Society. 2001;7:92–101
  35. Sturm W, Willmes K, Horn W. Leistungsprüfsystem für 50-90 jährige (LPS 50+). Göttingen: Hogrefe; 1993;
  36. Thiel A, Hilker R, Kessler J, Habedank B, Herholz K, Heiss W-D. Activation of basal ganglia loops in idiopathic Parkinson's disease: a PET study. Journal of Neural Transmission. 2003;110:1303–1311
  37. Tranel D, Bechara A, Denburg NL. Asymmetric functional roles of right and left ventromedial prefrontal cortices in social conduct, decision-making, and emotional processing. Cortex. 2002;38:589–612
  38. Whitney KA, Fastenau PS, Evans JD, Lysaker PH. Comparative neuropsychological function in obsessive-compulsive disorder and schizophrenia with and without obsessive-compulsive symptoms. Schizophrenia Research. 2004;69:75–83
  39. World Health Organization . International Statistical Classification of Diseases and Health Related Problems, Tenth Version (ICD-10). Geneva: Author; 1994;
  40. Zuckerman M, Kolin EA, Pric L, Zoob I. Development of a sensation-seeking scale. Journal of Consulting and Clinical Psychology. 1964;28:477–482

PII: S0165-1781(04)00253-7

doi: 10.1016/j.psychres.2004.10.003

Psychiatry Research
Volume 133, Issue 1 , Pages 91-99 , 30 January 2005

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