Psychiatry Research
Volume 133, Issue 2 , Pages 277-280, 28 February 2005

Lack of extrapyramidal side effects predicts quality of life in outpatients treated with clozapine or with typical antipsychotics

  • Sergio A. Strejilevich

      Affiliations

    • Servicio de Psicopatología, Hospital General de Agudos Parmenio Piñero, Av. Varela 1301, Buenos Aires, Argentina
    • ,
  • Ana Palatnik

      Affiliations

    • Servicio de Psicopatología, Hospital General de Agudos Parmenio Piñero, Av. Varela 1301, Buenos Aires, Argentina
    • ,
  • Rubén Avila

      Affiliations

    • Servicio de Psicopatología, Hospital General de Agudos Parmenio Piñero, Av. Varela 1301, Buenos Aires, Argentina
    • ,
  • Julián Bustin

      Affiliations

    • Servicio de Psicopatología, Hospital General de Agudos Parmenio Piñero, Av. Varela 1301, Buenos Aires, Argentina
    • ,
  • Julieta Cassone

      Affiliations

    • Servicio de Psicopatología, Hospital General de Agudos Parmenio Piñero, Av. Varela 1301, Buenos Aires, Argentina
    • ,
  • Soledad Figueroa

      Affiliations

    • Servicio de Psicopatología, Hospital General de Agudos Parmenio Piñero, Av. Varela 1301, Buenos Aires, Argentina
    • ,
  • Mariana Gimenez

      Affiliations

    • Servicio de Psicopatología, Hospital General de Agudos Parmenio Piñero, Av. Varela 1301, Buenos Aires, Argentina
    • ,
  • Gabriel A. de Erausquin

      Affiliations

    • Departments of Psychiatry and Neurology, Washington University School of Medicine, 660 S. Euclid Ave, Campus Box 8134, St Louis, MO 63110, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 314 362 5186; fax: +1 314 747 2983.

Received 7 January 2004; received in revised form 22 October 2004; accepted 25 October 2004.

Abstract 

We compared symptom severity and quality of life (QOL) in schizophrenic patients adequately treated with typical antipsychotics (TAP) or clozapine (CZP). Groups did not differ in symptom severity or QOL. Clozapine caused fewer extrapyramidal symptoms. Negative and extrapyramidal symptoms predicted QOL. Similar outcome in both groups suggests a common ceiling to antipsychotic efficacy.

Keywords: Parkinsonism, Negative symptoms, Treatment outcome

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PII: S0165-1781(04)00270-7

doi:10.1016/j.psychres.2004.10.009

Psychiatry Research
Volume 133, Issue 2 , Pages 277-280, 28 February 2005

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