Psychiatry Research
Volume 133, Issue 1 , Pages 13-21 , 30 January 2005

The expression of retinoic acid receptor alpha is increased in the granule cells of the dentate gyrus in schizophrenia

  • Lise Rioux

      Affiliations

    • Corresponding Author InformationCorresponding author. Present address: Laboratory for BioImaging and Anatomical Informatics, Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129-1096, USA. Tel.: +1 215 991 8410; fax: +1 215 843 9367.
  • ,
  • Steven Edward Arnold

Received 7 April 2004 ,Revised 15 September 2004 ,Accepted 8 November 2004.

References 

  1. Ahn MJ, Langenfeld J, Moasser MM, Rusch V, Dmitrovsky E. Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML. Oncogene. 1995;10(12):2307–2314
  2. Arai H, Schmidt ML, Lee VM, Hurtig HI, Greenberg BD, Adler CH, et al. Epitope analysis of senile plaque components in the hippocampus of patients with Parkinson's disease. Neurology. 1992;42(7):1315–1322
  3. Arnold SE, Rioux L. Challenges, status and opportunities for studying developmental neuropathology in adult schizophrenia. Schizophrenia Bulletin. 2001;27(3):395–416
  4. Arnold SE, Gur RE, Shapiro RM, Fisher KR, Moberg PJ, Gibney MR, et al. Prospective clinicopathologic studies of schizophrenia: accrual and assessment of patients. American Journal of Psychiatry. 1995;152(5):731–737
  5. Barbeau D, Liang JJ, Robitaille Y, Quirion R, Srivastava LK. Decreased expression of the embryonic form of the neural cell adhesion molecule in schizophrenic brains. Proceedings of the National Academy of Sciences of the United States of America. 1995;92:2785–2789
  6. Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J. 1996;10:940–954
  7. Chiang MY, Misner D, Kempermann G, Schikorski T, Giguere V, Sucov HM, et al. An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression. Neuron. 1998;21(6):1353–1361
  8. Cohen RN, Brzostek S, Kim B, Chorev M, Wondisford FE, Hollenberg AN. The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains. Molecular Endocrinology. 2001;15(7):1049–1061
  9. Dracheva S, Marras SA, Elhakem SL, Kramer FR, Davis KL, Haroutunian V. N-methyl-d-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia. American Journal of Psychiatry. 2001;158(9):1400–1410
  10. Eriksson PS, Perfilieva E, Bjork-Eriksson T, Alborn AM, Nordborg C, Peterson DA, et al. Neurogenesis in the adult human hippocampus. Nature Medicine. 1998;4(11):1313–1317
  11. Goodman AB. Chromosomal locations and modes of action of genes of the retinoid (vitamin A) system support their involvement in the etiology of schizophrenia. American Journal of Medical Genetics. 1995;60:335–348
  12. Goodman AB. Congenital anomalies in relatives of schizophrenic probands may indicate a retinoid pathology. Schizophrenia Research. 1996;19:163–170
  13. Goodman AB. Three independent lines of evidence suggest retinoids as causal to schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 1998;95:7240–7244
  14. Grimwood S, Slater P, Deakin JF, Hutson PH. NR2B-containing NMDA receptors are up-regulated in temporal cortex in schizophrenia. NeuroReport. 1999;10(3):461–465
  15. Gundersen HJG, Bendtsen TF, Korbo L, Marcussen N, Moller A, Nielsen K, et al. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS. 1988;96:379–394
  16. Hakak Y, Walker JR, Li C, Wong WH, Davis KL, Buxbaum JD, et al. Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 2000;98(8):4746–4751
  17. Harrison PJ. The neuropathology of schizophrenia, a critical review of the data and their interpretation. Brain. 1999;122:593–624
  18. Hemby SE, Ginsberg SD, Brunk B, Arnold SE, Trojanowski JQ, Eberwine JH. Gene expression profile for schizophrenia: discrete neuron transcription patterns in the entorhinal cortex. Archives of General Psychiatry. 2002;59(7):631–640
  19. Insausti R, Tunon T, Sobreviela T, Insausti AM, Gonzalo LM. The human entorhinal cortex: a cytoarchitectonic analysis. Journal of Comparative Neurology. 1995;355(2):171–198
  20. Kandel ER. Cellular mechanisms of learning and the biological basis of individuality. In:  Kandel ER, et al. editor. Principles of Neural Science. New York: McGraw-Hill; 2000;1414 pp.
  21. Kastner P, Mark M, Chambon P. Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life?. Cell. 1995;83:859–869
  22. Kéri S, Janka Z. Critical evaluation of cognitive dysfunction as endophenotypes of schizophrenia. Acta Psychiatrica Scandinavica. 2004;110:83–91
  23. Krezel W, Ghyselinck N, Samad TA, Dupé V, Kastner P, Borelli E, et al. Impaired locomotion and dopamine signaling in retinoid receptor mutant mice. Science. 1998;279:863–866
  24. Krezel W, Kastner P, Chambon P. Differential expression of retinoic receptors in the adult mouse central nervous system. Neuroscience. 1999;89(4):1291–1300
  25. LaMantia AS. Forebrain induction, retinoic acid, and vulnerability to schizophrenia: insights from molecular and genetic analysis in developing mice. Biological Psychiatry. 1999;46(1):19–30
  26. Langlois MC, Beaudry G, Zakki H, Rouillard C, Levesque D. Impact of antipsychotic drug administration on the expression of nuclear receptors in the neocortex and striatum of the rat brain. Neuroscience. 2001;106(1):117–128
  27. Law AJ, Deakin JF. Asymmetrical reductions of hippocampal NMDAR1 glutamate receptor mRNA in the psychoses. NeuroReport. 2001;12(13):2971–2974
  28. Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T, et al. Purification, cloning, and RXR identity of the Hela cell factor with RAR or TR heterodimerizes to bind target sequences efficiently. Cell. 1992;68:377–395
  29. Leroy P, Krust A, Zelent A, Mendelsohn C, Garnier JM, Kastner P, et al. Multiple isoforms of the mouse retinoic acid receptor α are generated by alternative splicing and differential induction by retinoic acid. EMBO Journal. 1991;10:59–69
  30. Leroy P, Nakshatri H, Chambon P. Mouse retinoic acid receptor α2 isoform is transcribed from a promoter that contains a retinoic acid response element. Proceedings of the National Academy of Sciences of the United States of America. 1991;88:10138–10142
  31. Marshall GM, Nason-Burchenal K, Moasser MM, Dmitrovsky E. Regulation of retinoic acid receptor alpha expression in human neuroblastoma cell lines and tumor tissue. Anticancer Research. 1994;14(2A):437–441
  32. Maynard TM, Linmarie S, Lieberman JA, LaMantia A-S. Neural development, cell–cell signaling, and the “two-hit” hypothesis of schizophrenia. Schizophrenia Bulletin. 2001;27(3):457–476
  33. Meyer-Lindenberg A, Poline JB, Kohn PD, Holt JL, Egan MF, Weinberger DR, et al. Evidence for abnormal cortical functional connectivity during working memory in schizophrenia. American Journal of Psychiatry. 2001;158(11):1809–1817
  34. Middleton FA, Mirnics K, Pierri JN, Lewis DA, Levitt P. Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia. Journal of Neuroscience. 2002;22(7):2718–2729
  35. Mirnics K, Middleton FA, Marquez AM, Lewis DA, Levitt P. Molecular characterization of schizophrenia revealed by microarray analysis of gene expression in prefrontal cortex. Neuron. 2000;28:53–67
  36. Miyaoka T, Seno H, Ishino H. Increased expression of Wnt-1 in schizophrenic brains. Schizophrenia Research. 1999;38:1–6
  37. Pizzi M, Boroni F, Bianchetti A, Moraitis C, Sarnio I, Benarese M, et al. Expression of functional NR1/NR2B-type NMDA receptors in neuronally differentiated SK-N-SH human cell line. European Journal of Neuroscience. 2002;16(12):2342–2350
  38. Reynolds K, Reynolds K, Zimmer AM, Zimmer A. Regulation of RAR beta 2 mRNA expression: evidence for an inhibitory peptide encoded in the 5′-untranslated region. Journal of Cellular Biology. 1996;134(4):827–835
  39. Samad TA, Krezel W, Chambon P, Borrelli E. Regulation of dopaminergic pathways by retinoids: activation of the D2 receptor promoter by members of the retinoic acid receptor-retinoid X receptor family. Proceedings of the National Academy of Sciences of the United States of America. 1997;94:14349–14354
  40. Saykin AJ, Gur RC, Gur RE, Mozley PD, Resnick SM, Kester DB, et al. Neuropsychological function in schizophrenia. Selective impairment in memory. Archives in General Psychiatry. 1991;48(7):618–624
  41. Schock Citver A, Sheilds AM, Ciaccia LM, Schulingkamp RJ, Raffa RB. Indirect modulation of dopamine D2 receptors as potential pharmacotherapy for schizophrenia: III. Retinoids. Journal of Clinical Pharmacology and Therapy. 2002;27:161–168
  42. Sower AC, Bird ED, Perrone-Bizzozero NI. Increased levels of GAP-43 protein in schizophrenic brain tissues demonstrated by a novel immunodetection method. Molecular Chemistry and Neuropathology. 1995;24(1):1–11
  43. Sun G, Porter W, Safe S. Estrogen-induced retinoic acid alpha 1 gene expression: role of estrogen receptor-Sp1 complex. Molecular Endocrinology. 1998;12(6):882–890
  44. Taneja R, Rochette-Egly C, Plassat JL, Penna L, Gaub MP, Chambon P. Phosphorylation of activation functions AF-1 and AF-2 of RAR alpha and RAR gamma is indispensible for differentiation of F9 cells upon retinoic acid and cAMP treatment. EMBO Journal. 1997;16(21):6452–6465
  45. Waxter, M.P., Crook, J.M., Hyde, T.M., Kleinman, J.E., Weinberger, D.R., Becker, K.G., Freed, W.J., 2002. Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary study 58, 11–20.
  46. Weinberger DR. Schizophrenia as a neurodevelopmental disorder. In:  Hirch SR,  Weinberger DR editor. Schizophrenia. Cambridge: Blackwell Science; 1995;p. 293–323
  47. Werme M, Ringholm A, Olson L, Brene S. Differential patterns of induction of NGF1-B, Nor 1 and c-fos mRNAs in striatal subregions by haloperidol and clozapine. Brain Research. 2000;863(1–2):112–119
  48. Wuarin L, Chang B, Wada R, Sidell N. Retinoic acid up-regulates nuclear retinoic acid receptor-alpha expression in human neuroblastoma cells. International Journal of Cancer. 1994;56(6):840–845
  49. Zetterstrom RH, Lindqvist E, Mata de Urquiza A, Tomac A, Eriksson U, Perlmann T, et al. Role of retinoids in the CNS: differential expression of retinoid proteins and receptors and evidence for presence of retinoic acid. European Journal of Neuroscience. 1999;11:407–416

PII: S0165-1781(04)00291-4

doi: 10.1016/j.psychres.2004.11.003

Psychiatry Research
Volume 133, Issue 1 , Pages 13-21 , 30 January 2005