Psychiatry Research
Volume 134, Issue 1 , Pages 101-104, 30 March 2005

Cytokine production and modulation: Comparison of patients with chronic fatigue syndrome and normal controls

Department of Child Development, School of Medicine, Kumamoto University, Kumamoto, Japan

Received 29 June 2004; received in revised form 11 August 2004; accepted 10 January 2005.

Abstract 

We studied cytokine production in 15 patients with chronic fatigue syndrome (CFS) and 23 controls. CFS patients' peripheral blood mononuclear cells were cultured with lipopolysaccharide or phytohemagglutinin. Enzymatic immunoassay indicated cytokine concentration in culture supernatants. CFS patients showed significantly lower mRNA levels and transforming growth factor-beta1 (TGF-β1) production. Cytokine dysregulation affects CFS pathogenesis. TGF-β1 may aid treatment because it affects CFS inflammatory characteristics.

Keywords: Chronic fatigue syndrome (CFS), Cytokines, Transforming growth factor-beta1 (TGF-β1), Peripheral blood mononuclear cells (PBMC)

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PII: S0165-1781(05)00007-7

doi:10.1016/j.psychres.2005.01.002

Psychiatry Research
Volume 134, Issue 1 , Pages 101-104, 30 March 2005

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