Psychiatry Research
Volume 134, Issue 3 , Pages 267-273 , 30 April 2005

Enhanced serum cholesterol and triglyceride levels in bulimia nervosa: Relationships to psychiatric comorbidity, psychopathology and hormonal variables

  • Palmiero Monteleone

      Affiliations

    • Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 81 5666517; fax: +39 81 5666523.
    • ,
  • Paolo Santonastaso

      Affiliations

    • Department of Neurosciences, University of Padua, Padua, Italy
    • ,
  • Marilena Pannuto

      Affiliations

    • Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy
    • ,
  • Angela Favaro

      Affiliations

    • Department of Neurosciences, University of Padua, Padua, Italy
    • ,
  • Lorenza Caregaro

      Affiliations

    • Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    • ,
  • Eloisa Castaldo

      Affiliations

    • Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy
    • ,
  • Tatiana Zanetti

      Affiliations

    • Department of Neurosciences, University of Padua, Padua, Italy
    • ,
  • Mario Maj

      Affiliations

    • Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy

,Accepted 8 June 2004.

References 

  1. Agargun MY. Serum cholesterol concentration, depression, and anxiety. Acta Psychiatrica Scandinavica. 2002;105:81–83
  2. Almeida-Montes LG, Valles-Sanchez V, Moreno-Aguilar J, Chavez-Balderas RA, Garcia-Marin JA, Cortes Sotres JF, et al. Relation of serum cholesterol, lipid, serotonin and tryptophan levels to severity of depression and to suicide attempts. Journal of Psychiatry & Neuroscience. 2000;25:371–377
  3. Andreasen NC, Endicott J, Spitzer RL, Winokur G. The family history method using diagnostic criteria: reliability and validity. Archives of General Psychiatry. 1997;34:1229–1235
  4. Apter A, Laufer N, Bar-Sever M, Har-Even D, Ofek H, Weizman A. Serum cholesterol, suicidal tendencies, impulsivity, aggression, and depression in adolescent psychiatric inpatients. Biological Psychiatry. 1999;46:532–541
  5. Archbold RA, Timmis AD. Cholesterol lowering and coronary artery disease: mechanism of risk reduction. Heart. 1998;80:543–547
  6. Boston P, Serdar M, Reveley D, Reveley M. Cholesterol and mental disorder. British Journal of Psychiatry. 1996;169:682–689
  7. Brambilla F. Aetiopathogenesis and pathophysiology of bulimia nervosa, biological bases and implications for treatment. CNS Drugs. 2001;15:119–136
  8. Brambilla F, Monteleone P. Physical complications and physiological aberrations in eating disorders: a review. In:  Maj M,  Halmi K,  Lòpez-Ibor JJ,  Sartorius N editor. Eating Disorders. Chichester, UK: John Wiley & Sons, Ltd; 2003;p. 139–192
  9. Buss AH, Durkee A. An inventory for assessing different kinds of hostility. Journal of Consulting Psychology. 1957;21:343–349
  10. Case T, Lemieux S, Kennedy SH, Lewis GF. Elevated plasma lipids in patients with binge eating disorders are found only in those who are anorexic. International Journal of Eating Disorders. 1999;25:187–193
  11. Dixon J. BMDP Statistical Software. Berkeley: University of California Press; 1985;
  12. First MB, Spitzer RL, Gibbon M, Williams JB. Structured Clinical Interview for DSM-IV Axis I Disorders SCID-I: Research Version. New York: Biometrics Research Department, New York State Psychiatric Institute; 1995;
  13. First MB, Gibbon M, Spitzer RL, Williams JBW, Benjamin LS. Structured Clinical Interview for DSM-IV Axis II Personality Disorders SCID-II. Washington, DC: American Psychiatric Press; 1997;
  14. Galderisi S, Mucci A, Monteleone P, Sorrentino D, Piegari G, Maj M. Neurocognitive functioning in subjects with eating disorders, the influence of neuroactive steroids. Biological Psychiatry. 2003;53:921–927
  15. Garner DM. Eating Disorder Inventory-2 Professional Manual. Odessa, FL: Psychological Assessment Resources, Inc.; 1991;
  16. Gendall KA, Joyce PR, Carter FA, McIntosh VV, Bulik CM. The effect of bulimia nervosa on plasma glucose and lipids. Physiology and Behavior. 2002;77:99–105
  17. Hayward C, Taylor B, Roth WT, King R, Agras WS. Plasma lipid levels in patients with panic disorder or agoraphobia. American Journal of Psychiatry. 1989;146:917–919
  18. Henderson M, Freeman CPL. A self-rating scale for bulimia, the BITE. British Journal of Psychiatry. 1987;150:18–24
  19. Kaye WH, Gwirtsman HE, George DT, Jimerson DC, Ebert MH, Lake CR. Disturbances of noradrenergic systems in normal weight bulimia, relationship to diet and menses. Biological Psychiatry. 1990;27:4–21
  20. Klinefelter HF. Hypercholesterolemia in anorexia nervosa. Journal of Clinical Endocrinology. 1965;25:1520–1521
  21. Lecrubier Y, Sheehan D, Weller E, Amorim P, Bonora I, Sheehan K, et al. The Mini International Neuropsychiatric Interview (M.I.N.I.). A short diagnostic structured interview, reliability and validity according to the CIDI. European Psychiatry. 1997;12:224–231
  22. Mira M, Stewart PM, Abraham S. Hormonal and biochemical abnormalities in women suffering from eating disorders. Pediatrician. 1985;12:148–156
  23. Mira M, Stewart PM, Vizzard J, Abraham S. Biochemical abnormalities in anorexia and bulimia. Annals of Clinical Biochemistry. 1987;24:29–35
  24. Monteleone P, Luisi M, Colurcio B, Casarosa E, Monteleone P, Ioime R, et al. Plasma levels of neuroactive steroids are increased in untreated women with anorexia nervosa or bulimia nervosa. Psychosomatic Medicine. 2001;63:62–68
  25. Montgomery SA, Åsberg M. A new depression scale designed to be sensitive to changes. British Journal of Psychiatry. 1979;134:382–389
  26. Mordasini R, Klose G, Greten H. Secondary type II hyperlipoproteinemia in patients with anorexia nervosa. Metabolism. 1979;27:71–79
  27. Muldoon MF, Manuck SB, Mathews KA. Lowering cholesterol concentrations and mortality, a quantitative review of primary prevention trials. British Medical Journal. 1990;301:309–314
  28. National Cholesterol Education Program Expert Panel . Report of the National Cholesterol Education Program Expert Panel on the detection, evaluation, treatment of high blood cholesterol in adults. Archives of Internal Medicine. 1988;148:36–69
  29. Nestel PJ. Cholesterol metabolism in anorexia nervosa and hypercholesterolemia. Journal of Clinical Endocrinology and Metabolism. 1974;38:325–328
  30. Pauporte J, Walsh T. Serum cholesterol in bulimia nervosa. International Journal of Eating Disorders. 2001;30:294–298
  31. Rupprecht R. Neuroactive steroids, mechanisms of action and neuropsychopharmacological properties. Psychoneuroendocrinology. 2003;28:139–168
  32. Sanchez-Muniz FJ, Marcos A, Varela P. Serum lipids and apolipoprotein B values, blood pressure and pulse rate in anorexia nervosa. European Journal of Clinical Nutrition. 1991;45:33–36
  33. Sarchiapone M, Camardese G, Roy A, Della Casa S, Satta MA, Gonzales B, et al. Cholesterol and serotonin indices in depressed and suicidal patients. Journal of Affective Disorders. 2001;67:217–219
  34. Sullivan PF, Gendall KA, Bulik CM, Carter FA, Joyce PR. Elevated total cholesterol in bulimia nervosa. International Journal of Eating Disorders. 1998;23:425–432
  35. Vize CM, Coker S. Hypercholesterolemia in bulimia nervosa. International Journal of Eating Disorders. 1994;15:293–295

PII: S0165-1781(05)00061-2

doi: 10.1016/j.psychres.2004.06.019

Psychiatry Research
Volume 134, Issue 3 , Pages 267-273 , 30 April 2005

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