Psychiatry Research
Volume 135, Issue 1 , Pages 53-63 , 15 May 2005

Effect of intravenous magnesium sulphate in reducing irritability and restlessness in pure and polysubstance opiate detoxification

  • Angela Naderi-Heiden

      Affiliations

    • Department of General Psychiatry, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria
    • Corresponding Author InformationCorresponding author. Tel.: +43 1 40 400 3568; fax: +43 1 40 400 3099.
  • ,
  • Richard Frey

      Affiliations

    • Department of General Psychiatry, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria
  • ,
  • Otto Presslich

      Affiliations

    • Department of General Psychiatry, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria
  • ,
  • Patrick Frottier

      Affiliations

    • Department of Social Psychiatry and Evaluation Research, Medical University of Vienna, Vienna, Austria
  • ,
  • Ulrike Willinger

      Affiliations

    • Department of General Psychiatry, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria
  • ,
  • Thomas Blasbichler

      Affiliations

    • Department of General Psychiatry, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria
  • ,
  • Ronald Smetana

      Affiliations

    • Department of Internal Medicine IV, Medical University of Vienna, Vienna, Austria
  • ,
  • Daniela Schmid

      Affiliations

    • Austrian Agency for Health and Food Safety, Vienna, Austria
  • ,
  • Siegfried Kasper

      Affiliations

    • Department of General Psychiatry, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria

Received 7 July 2004 ,Accepted 23 July 2004.

References 

  1. Arbeitsgemeinschaft für Methodik und Dokumentation in der psychiatrie . In: Das AMDP-System. Göttingen: Hogrefe Verlag; 1995;
  2. Attygalle D, Rodrigo N. Magnesium sulphate for control of spasms in severe tetanus. Can we avoid sedation and artificial sedation?. Anaesthesia. 1997;52:956–962
  3. Bregan S, Pickering G, Eschalier A, Dubray C. Mg increases morphine analgesic effect in different experimental models of pain. Anesthesiology. 2002;96:627–632
  4. Broers B, Giner F, Dumont P, Mino A. Inpatient opiate detoxification in Geneva: follow-up at 1 and 6 months. Drug and Alcohol Dependence. 2000;58:85–92
  5. Cholst IN, Steinberg SF, Tropper PJ, Fox HE, Segre GV, Bilezikian JP. The influence of hypermagnesemia on serum calcium and parathyroid hormone levels in human subjects. New England Journal of Medicine. 1984;310:1221–1225
  6. Collaborative Eclampsia Trial Group. Which anticonvulsant for women with eclampsia? Evidence from the Collaborative Eclampsia Trial. Lancet. 1995;345:1455–1463
  7. Durlach J. Magnesium-überschuβ. In:  Durlach J editors. Magnesium in Der Klinischen Praxis. Jena-Stuttgart: Gustav Fischer Verlag; 1992;p. 215–233
  8. Ebel H. Magnesium metabolism: a review. Journal of Clinical Chemistry and Clinical Biochemistry. 1980;18:257–270
  9. Fagan D, Lamont M, Jostell KG, Tiplady B, Scott DB. A study of the psychometric effects of chlormethiazole in healthy young and elderly subjects. Age and Ageing. 1990;19:395–402
  10. Fodor G, Kapitany T, Miller-Reiter E, Diamant K, Presslich O, Kasper S. Magnesium as a sedative agent in agitated psychotic states. Magnesium Research. 1995;1(Suppl. 8):28–29
  11. Frakes MA, Richardson LE. Magnesium sulfate therapy in certain emergency conditions. American Journal of Emergency Medicine. 1997;15:182–187
  12. Garfinkel L, Garfinkel G. Magnesium regulation of the glycolytic pathway and the enzymes involved. Magnesium. 1985;4:60–72
  13. Gowing LR, Farrell M, Ali RL, White JM. α2-Adrenergic agonists in opioid withdrawal. Addiction. 2002;97:49–58
  14. Heiden A, Frey R, Presslich O, Smetana R, Kasper S. Parenterale Magnesiumtherapie bei Opiatdetoxifikation. Journal für Mineralstoffwechsel. 1997;3:18–19
  15. Heiden A, Frey R, Presslich O, Blasbichler T, Smetana R, Kasper S. Treatment of severe mania with intravenous magnesium sulphate as a supplementary therapy. Psychiatry Research. 1999;89:239–246
  16. Hoffmeister F, Tettenborn D. Calcium agonists and antagonists of the dihydropyridine type: antinociceptive effects, interference with opiate-mu-receptor agonists and neuropharmacological actions in rodents. Psychopharmacology. 1986;90:299–307
  17. Iseri LT, French JH. Magnesium: nature's physiologic calcium blocker. American Heart Journal. 1984;108:188–194
  18. James MFM. Clinical use of magnesium infusions in anesthesia. Anesthesia and Analgesia. 1992;74:129–136
  19. Koinig H, Wallner T, Marhofer P, Andel H, Horauf K, Mayer N. Magnesium sulfate reduces intra- and postoperative analgesic requirements. Anesthesia and Analgesia. 1998;87:206–210
  20. Kroin JS, McCarthy RJ, Von Roenn N, Schwab B, Tuman KJ, Ivankovich AD. Magnesium sulfate potentiates morphine antinociception at the spinal level. Anesthesia and Analgesia. 2000;90:913–917
  21. Lee W, O'Connell CM, Baskett TF. Maternal and perinatal outcomes of eclampsia: Nova Scotia, 1981–2000. Journal of Obstetrics and Gynaecology Canada. 2004;26:119–123
  22. Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. New England Journal of Medicine. 1994;330:613–622
  23. Lux E, Welsh SP, Brase DA, Dewey WL. Interaction of morphine with intrathecally administered calcium and calcium antagonists: evidence for supraspinal endogenous opioid mediation of intrathecal calcium-induced antinociception in mice. Journal of Pharmacology and Experimental Therapeutics. 1988;246:500–507
  24. Martin G, Ahmed SH, Blank T, Spiess J, Koob GF, Siggins GR. Chronic morphine treatment alters NMDA receptor-mediated synaptic transmission in the nucleus accumbens. Journal of Neuroscience. 1999;19:9081–9089
  25. McCarthy RJ, Kroin JS, Tuman KJ, Penn RD, Ivankovich AD. Antinociceptive potentiation and attenuation of tolerance by intrathecal co-infusion of magnesium sulfate and morphine in rats. Anesthesia and Analgesia. 1998;86:830–836
  26. McLean RM. Magnesium and its therapeutic uses: a review. American Journal of Medicine. 1994;96:63–76
  27. McLellan AT, Kushner H, Metzger D, Peters R, Smith I, Grissom G, et al. The fifth edition of the addiction severity index. Journal of Substance Abuse Treatment. 1992;9:199–213
  28. Miller-Reiter E, Presslich O, Fodor G, Frey R, Kasper S. Magnesium as an aid in opioid detoxification and withdrawal. Advances in Magnesium Research. 1995;1:242–246
  29. Miranda HF, Bustamante D, Kramer V, Pelissier T, Saavedra H, Paeile C, et al. Antinociceptive effects of Ca2+ channel blockers. European Journal of Pharmacology. 1992;217:137–141
  30. Monif GRG, Savory J. Iatrogenic maternal hypocalcemia following magnesium sulfate therapy. Journal of the American Medical Association. 1972;219:1469–1470
  31. Morgan MY. The management of alcohol withdrawal using chlormethiazole. Alcohol and Alcoholism. 1995;30:771–774
  32. Murck H. Magnesium and affective disorders. Nutritional Neuroscience. 2002;5:375–389
  33. Pritchard JA. The use of magnesium sulphate in pre-eclampsia. Journal of Reproductive Medicine. 1979;23:107–114
  34. Reddy VG. Pharmacotherapy of tetanus—a review. Middle East Journal of Anesthesiology. 2002;16:419–442
  35. Santillán R, Maestre JM, Hurlé MA, Florez J. Enhancement of opiate analgesia by nimodipine in cancer patients chronically treated with morphine: a preliminary report. Pain. 1994;58:129–132
  36. Shechter M. Does magnesium have a role in the treatment of patients with coronary artery disease?. American Journal of Cardiovascular Drugs. 2003;3:231–239
  37. Silverman RA, Osborn H, Runge J, Gallagher EJ, Chiang W, Feldman J, et al. IV magnesium sulfate in the treatment of acute severe asthma—a multicenter randomized controlled trial. Chest. 2002;122:489–497
  38. Tramèr MR, Schneider J, Marti RA, Rifat K. Role of magnesium sulfate in postoperative analgesia. Anaesthesiology. 1996;84:340–347
  39. Wagner E, Presslich O, Fischer G, Schneider C, Diamant K, Kasper S. Der Einsatz von Morphin-retard in der stationären Detoxifikationsbehandlung opiatabhängiger bzw. polytoxikomaner Patienten. Wiener Zeitschrift für Suchtforschung. 1999;22:21–27
  40. Wang RI, Wiesen RL, Lamid S, Roh BL. Rating the presence and severity of opiate dependence. Clinical Pharmacology and Therapeutics. 1974;16:653–658
  41. Wilder-Smith CH, Knöpfli R, Wilder-Smith OHG. Perioperative magnesium infusion and postoperative pain. Acta Anaesthesiologica Scandinavica. 1997;14:1023–1027
  42. Wong CH, Dey P, Yarmush J, Wu WH, Zbuzek VK. Nifedipine-induced analgesia after epidural injection in rats. Anesthesia and Analgesia. 1994;79:303–306
  43. Yamakura T, Sakimura K, Shimoji K. Direct inhibition of the N-methyl-d-aspartate receptor channel by high concentrations of opioids. Anesthesiology. 1999;91:1053–1063

PII: S0165-1781(05)00099-5

doi: 10.1016/j.psychres.2004.07.012

Psychiatry Research
Volume 135, Issue 1 , Pages 53-63 , 15 May 2005