Psychiatry Research
Volume 136, Issue 1 , Pages 27-34 , 15 July 2005

P50 inhibitory gating deficit is correlated with the negative symptomatology of schizophrenia

  • Sandrine Louchart-de la Chapelle

      Affiliations

    • Service Hospitalo-Universitaire de Psychiatrie, CHU C. Nicolle et CH du Rouvray, INSERM Unité 614, UFR de Médecine, 1 rue de Germont, 76031 Rouen Cedex, France
  • ,
  • Daniel Levillain

      Affiliations

    • Service d'explorations électrophysiologiques, CH du Rouvray, Roven, France
  • ,
  • Jean-François Ménard

      Affiliations

    • Département de Biostatistiques, CHU C. Nicolle, Rouen, France
  • ,
  • Alexis Van der Elst

      Affiliations

    • Service Hospitalo-Universitaire de Psychiatrie, CHU C. Nicolle et CH du Rouvray, INSERM Unité 614, UFR de Médecine, 1 rue de Germont, 76031 Rouen Cedex, France
  • ,
  • Gabrielle Allio

      Affiliations

    • Service Hospitalo-Universitaire de Psychiatrie, CHU C. Nicolle et CH du Rouvray, INSERM Unité 614, UFR de Médecine, 1 rue de Germont, 76031 Rouen Cedex, France
  • ,
  • Sadeq Haouzir

      Affiliations

    • Service Hospitalo-Universitaire de Psychiatrie, CHU C. Nicolle et CH du Rouvray, INSERM Unité 614, UFR de Médecine, 1 rue de Germont, 76031 Rouen Cedex, France
  • ,
  • Sonia Dollfus

      Affiliations

    • Service Hospitalo-Universitaire de Psychiatrie, Centre Esquirol, Caen, France
  • ,
  • Dominique Campion

      Affiliations

    • Service Hospitalo-Universitaire de Psychiatrie, CHU C. Nicolle et CH du Rouvray, INSERM Unité 614, UFR de Médecine, 1 rue de Germont, 76031 Rouen Cedex, France
  • ,
  • Florence Thibaut

      Affiliations

    • Service Hospitalo-Universitaire de Psychiatrie, CHU C. Nicolle et CH du Rouvray, INSERM Unité 614, UFR de Médecine, 1 rue de Germont, 76031 Rouen Cedex, France
    • Corresponding Author InformationCorresponding author. Unité de Psychiatrie, CHU C. Nicolle, 1 rue de Germont, 76031 Rouen Cedex, France. Fax: +33 2 35 71 02 38.

Received 25 February 2003 ,Accepted 18 April 2003.

References 

  1. Adler LE, Pachtman E, Franks RD, Pecevich M, Waldo MC, Freedman R. Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia. Biological Psychiatry. 1982;17:639–654
  2. Adler LE, Waldo MC, Tatcher A, Cawthra E, Baker N. Lack of relationship of auditory sensory gating defects to negative symptoms in schizophrenia. Schizophrenia Research. 1990;3:131–138
  3. Adler LE, Hoffer LD, Wiser A, Freedman R. Normalization of auditory physiology by cigarette smoking in schizophrenic patients. American Journal of Psychiatry. 1993;150:1856–1861
  4. Aitchison KJ, Meehan RM, Murray R. First Episode Psychosis. London: Martin-Dunitz Ed.; 1999;138 pp.
  5. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. 4th ed.. Washington, DC: APA; 1994;
  6. Baker NJ, Staunton M, Adler LE, Gerhardt GA, Drebing C, Waldo M, et al. Sensory gating deficits in psychiatric inpatients: relation to catecholamine metabolites in different diagnostic groups. Biological Psychiatry. 1990;27:519–528
  7. Boutros N. Dopamine and the P50. Biological Psychiatry. 1998;44:932–938
  8. Boutros N, Zouridakis G, Overall J. Replication and extension of P50 findings in schizophrenia. Clinical Electroencephalography. 1991;22:40–45
  9. Braff DL. Information processing and attention dysfunctions in schizophrenia. Schizophrenia Bulletin. 1993;19:233–259
  10. Cadenhead KS, Light GA, Geyer MA, Braff DL. Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypical personality disorder. American Journal of Psychiatry. 2000;157:55–59
  11. Clementz BA, Geyer MA, Braff DL. P50 suppression among schizophrenia and normal comparison subjects: a methodological analysis. Biological Psychiatry. 1997;41:1035–1044
  12. Croft RJ, Lee A, Bertolot J, Gruzelier JH. Association of P50 suppression and desensitization with perceptual and cognitive features of “unreality” in schizotypy. Biological Psychiatry. 2001;50:441–446
  13. Fein G, Biggins C, MacKay S. Cocaine abusers have reduced auditory P50 amplitude and suppression compared to both normal controls and alcoholics. Biological Psychiatry. 1996;39:955–965
  14. Foster P. Neuroleptic equivalence. Pharmacology Journal. 1989;30:431–432
  15. Franks DR, Alder LE, Waldo MC, Alpert J, Freedman R. Neurophysiobiological studies of sensory gating in mania. Comparison with schizophrenia. Biological Psychiatry. 1983;18:989–1005
  16. Freedman R, Adler LE, Waldo MC, Pachtman E, Franks RD. Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia: comparison of medicated and drug-free patients. Biological Psychiatry. 1983;18:537–551
  17. Freedman R, Adler LE, Gerhardt GA, Waldo M, Baker N, Rose GM, et al. Neurobiological studies of sensory gating in schizophrenia. Schizophrenia Bulletin. 1987;13:669–678
  18. Freedman R, Adler LE, Waldo M. Gating of the auditory evoked potential in children and adults. Psychophysiology. 1987;24:223–227
  19. Freedman R, Coon H, Myles-Worsley M, Orr-Urteger A, Olincy A, Davis A, et al. Linkage of a neurophysiological deficit in schizophrenia to chromosome 15 locus. Proceedings of the National Academy of Sciences of the United States of America. 1997;94:587–592
  20. Fyer AJ, Endicott J, Manuzza S, Klein DF. Schedule for Affective Disorders and Schizophrenia—Lifetime Version Modified for the Study of Anxiety Disorders. New York: New York State Psychiatric Institute; 1985;
  21. Hetrick WP, Sandman CA, Bunney WE, Jin Y, Potkin SG, White MH. Gender differences in gating of the auditory evoked potential in normal subjects. Biological Psychiatry. 1996;39:51–58
  22. Jin Y, Bunney WE, Sandman CA, Patterson JV, Fleming K, Moenter JR, et al. Is P50 suppression a measure of sensory gating in schizophrenia?. Biological Psychiatry. 1998;43:873–878
  23. Kathmann N, Engel RR. Sensory gating in normals and schizophrenics: a failure to find strong P50 suppression in normals. Biological Psychiatry. 1990;27:1216–1226
  24. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin. 1987;13:261–276
  25. Light GA, Braff DL. Human and animal studies of schizophrenia-related gating deficits. Current Psychiatry Reports. 1999;1:31–40
  26. Light GA, Braff DL. Do self-reports of perceptual anomalies reflect gating deficits in schizophrenia patients?. Biological Psychiatry. 2000;47:463–467
  27. McGhie A, Chapman J. Disorders of attention in early schizophrenia. British Journal of Medical Psychology. 1961;34:103–116
  28. Nagamoto HT, Adler LE, Waldo MC, Griffith J, Freedman R. Gating of auditory response in schizophrenics and normal controls. Effects of recording site and stimulation interval on the P50 wave. Schizophrenia Research. 1991;4:31–40
  29. Nuerchterlein KH, Dawson ME. Information processing and attentional functioning in the developmental course of schizophrenic disorders. Schizophrenia Bulletin. 1984;10:160–203
  30. Patterson JV, Jin Y, Glerczak BS, Herrick WP, Potkin S, Bunney WE, et al. Effects of temporal variability on P50 and the gating ratio in schizophrenia. Archives of General Psychiatry. 2000;57:57–64
  31. Raux G, Bonnet-Brilhault F, Louchart S, Houy E, Gantier R, Levillain D, et al. The −2bp deletion in exon 6 of the alpha 7-like nicotinic receptor subunit gene is a risk factor for the P50 sensory gating deficit. Molecular Psychiatry. 2002;7:1006–1011
  32. Robins LN, Helzen JE, Croughan J, Ratcliff KS. National institute of mental health diagnostic interview schedule: its history characteristics and validity. Archives of General Psychiatry. 1981;38:381–389
  33. Siegel C, Waldo MC, Mizner C, Adler LE, Freedman R. Deficit in sensory gating in schizophrenia patients and their relatives. Archives of General Psychiatry. 1984;41:607–612
  34. Thibaut F, Ribeyre JM, Dourmap N, Ménard JF, Dollfus S, Petit M. Plasma 3-methoxy-4-hydroxyphenyglycol and homovanillic acid measurements in deficit and nondeficit forms of schizophrenia. Biological Psychiatry. 1998;43:24–30
  35. Venables PH. Input dysfunction in schizophrenia. In:  Maher BA editors. Progress in Experimental Personality Research (I). New York: Academic Press; 1964;p. 1–47
  36. Waldo MC, Graze K, DeGraff Bender S, Adler LE, Freedman R. Premenstrual mood changes and gating of the auditory evoked potential. Psychoneuroendocrinology. 1987;12:35–40
  37. Waldo MC, Carey M, Myles-Worsley M, Cawthra E, Adler LE, Nagamoto HT, et al. Codistribution of sensory gating deficit and schizophrenia in multi-affected families. Psychiatry Research. 1991;39:257–268
  38. Ward PB, Hoffer LD, Liebert BJ, Catts SV, O'Donnell M, Adler LE. Replication of a P50 auditory gating deficit in Australian patients with schizophrenia. Psychiatry Research. 1996;64:121–135

PII: S0165-1781(05)00150-2

doi: 10.1016/j.psychres.2003.04.001

Psychiatry Research
Volume 136, Issue 1 , Pages 27-34 , 15 July 2005