Psychiatry Research
Volume 136, Issue 2 , Pages 173-179 , 15 September 2005

Familiality in a five-factor model of schizophrenia psychopathology: Findings from a 16-month follow-up study

  • Michael Ritsner

      Affiliations

    • Sha'ar Menashe Mental Health Center, Mobile Post Hefer 38814, Hadera, Israel
    • Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    • Corresponding Author InformationCorresponding author. Sha'ar Menashe Mental Health Center, Mobile Post Hefer 38814, Hadera, Israel. Tel.: +972 4 6278750; fax: +972 4 6278135.
    • ,
  • Yael Ratner

      Affiliations

    • Sha'ar Menashe Mental Health Center, Mobile Post Hefer 38814, Hadera, Israel
    • ,
  • Anatoly Gibel

      Affiliations

    • Sha'ar Menashe Mental Health Center, Mobile Post Hefer 38814, Hadera, Israel
    • ,
  • Ronit Weizman

      Affiliations

    • Tel Aviv Community Mental Health Center, Tel Aviv, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Received 11 September 2003 ,Accepted 12 April 2005.

References 

  1. Alda M, Ahrens B, Lit W, Dvorakova M, Labelle A, Zvolsky P, et al. Age of onset in familial and sporadic schizophrenia. Acta Psychiatrica Scandinavica. 1996;93:447–450
  2. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: APA; 1994;
  3. Arndt S, Andreasen NC, Flaum M, Miller D, Nopoulos P. A longitudinal study of symptom dimensions in schizophrenia. Prediction and patterns of change. Archives of General Psychiatry. 1995;52:352–360
  4. Cardno AG, Bowen T, Guy CA, Jones LA, McCarthy G, Williams NM, et al. CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia. Biological Psychiatry. 1999;45:1592–1596
  5. Cardno AG, Sham PC, Murray RM, McGuffin P. Twin study of symptom dimensions in psychoses. British Journal of Psychiatry. 2001;179:39–45
  6. Feldmann R, Hornung WP, Buchkremer G, Arolt V. The influence of familial loading on the course of schizophrenic symptoms and the success of psychoeducational therapy. Psychopathology. 2000;34:192–197
  7. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders, Patient Edition (SCID-P), Version 2. New York: New York State Psychiatric Institute; 1995;
  8. Fitzgerald PB, Rolfe TJ, Brewer K, Filia K, Collins J, Filia S, et al. Depressive, positive, negative and Parkinsonian symptoms in schizophrenia. Australian and New Zealand Journal of Psychiatry. 2002;36:340–346
  9. Guy W. ECDEU Assessment Manual for Psychopharmacology. Rockville, MD: U.S. Department of Health and Human Services; 1976;
  10. Hintze, J.L., 1998. NCSS 6.0. Statistical System for Windows. User's Guide. Number Cruncher Statistical Systems, Kaysville, UT.
  11. Kay SR, Fiszbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin. 1987;13:261–276
  12. Kendler KS, Maclean CJ. Estimating familial effects on age of onset and liability to schizophrenia: I. Results of a large sample family study. Genetic Epidemiology. 1990;7:409
  13. Malaspina D, Goetz RR, Yale S, Berman A, Friedman JH, Tremeau F, et al. Relation of familial schizophrenia to negative symptoms but not to the deficit syndrome. American Journal of Psychiatry. 2000;157:994–1003
  14. McEvoy JP, Freter S, Everett G, Geller JL, Appelbaum PS, Apperson LJ, et al. Insight and the clinical outcome of schizophrenic patients. Journal of Nervous and Mental Disease. 1989;177:48–51
  15. Mojtabai R. Duration of illness and structure of symptoms in schizophrenia. Psychological Medicine. 1999;29:915–924
  16. Myin-Germeys I, van Os J, Schwartz JE, Stone AA, Delespaul PA. Emotional reactivity to daily life stress in psychosis. Archives of General Psychiatry. 2001;58:1093–1208
  17. Nurnberger JI, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J, et al. Diagnostic Interview for Genetic Studies: rationale, unique features, and training. Archives of General Psychiatry. 1994;51:849–859
  18. Peralta V, Cuesta MJ, Martinez-Larrea A, Serrano JF. Patterns of symptoms in neuroleptic-naive patients with schizophrenia and related psychotic disorders before and after treatment. Psychiatry Research. 2001;105:97–105
  19. Ritsner M, Modai I, Endicott J, Rivkin O, Nechamkin Y, Barak P, et al. Differences in quality of life domains, psychopathological and psychosocial factors in psychiatric patients. Journal of Clinical Psychiatry. 2000;61:880–889
  20. Ritsner M, Modai I, Ziv H, Amir S, Halperin T, Weizman A, et al. An association of CAG repeats at the KCNN3 locus with symptom dimensions of schizophrenia. Biological Psychiatry. 2002;51:788–794
  21. Ritsner M, Modai I, Kurs R, Kostizky H, Ponizovsky A. Subjective quality of life measurements in severe mental health patients: measuring quality of life of psychiatric patients: comparison of two questionnaires. Quality of Life Research. 2002;11:553–561
  22. Ritsner M, Modai I, Ponizovsky A. The Talbieh Brief Distress Inventory: validation for use with psychiatric patients. Comprehensive Psychiatry. 2002;2:144–163
  23. Ritsner M, Ponizovsky A, Endicott J, Nechamkin Y, Rauchverger B, Silver H, et al. Relatively small impact adverse events of antipsychotics on life satisfaction of schizophrenia patients: a naturalistic study. European Neuropsychopharmacology. 2002;12:31–38
  24. Ritsner M, Kurs R, Gibel A, Hirschmann S, Shinkarenko E, Ratner Y. Predictors of quality of life in major psychoses: a naturalistic follow-up study. Journal of Clinical Psychiatry. 2003;64:308–315
  25. Rossell SL, Coakes J, Shapleske J, Woodruff PW, David AS. Insight: its relationship with cognitive function, brain volume and symptoms in schizophrenia. Psychological Medicine. 2003;33:111–119
  26. Schultz SK, Ho BC, Andreasen NC. Clinical features characterizing young-onset and intermediate-onset schizophrenia. Journal of Neuropsychiatry and Clinical Neuroscience. 2000;12:502–505
  27. Silverman JM, Mohs RC, Davidson M, Losonczy MF, Keefe RSE, Breitner JCS, et al. Familial schizophrenia and treatment response. American Journal of Psychiatry. 1987;144:1271–1276
  28. Suvisaari JM, Haukka J, Tanskanen A, Lonnqvist JK. Age at onset and outcome in schizophrenia are related to the degree of familial loading. British Journal of Psychiatry. 1998;173:494–500
  29. Vazquez-Barquero JL, Cuesta Nunez MJ, Herrera Castanedo S, Diez Manrique JF, Pardo G, Dunn G. Sociodemographic and clinical variables as predictors of the diagnostic characteristics of first episodes of schizophrenia. Acta Psychiatrica Scandinavica. 1996;94:149–155
  30. White L, Harvey PD, Opler L, Lindenmayer JP PANSS Study Group. Empirical assessment of the factorial structure of clinical symptoms in schizophrenia. Psychopathology. 1997;30:263–274
  31. Wickham H, Walsh C, Asherson P, Gill M, Owen MJ, McGuffin P, et al. Familiality of clinical characteristics in schizophrenia. Journal of Psychiatric Research. 2002;36:325–349
  32. Yamamoto K, Cubells JF, Gelernter J, Benkelfat C, Lalonde P, Bloom D, et al. Dopamine beta-hydroxylase (DBH) gene and schizophrenia phenotypic variability: a genetic association study. American Journal of Medical Genetics. 2003;117B:33–38

PII: S0165-1781(05)00164-2

doi: 10.1016/j.psychres.2005.04.006

Psychiatry Research
Volume 136, Issue 2 , Pages 173-179 , 15 September 2005

Article Tools