Psychiatry Research
Volume 137, Issue 1 , Pages 113-121 , 15 November 2005

Chronic repetitive transcranial magnetic stimulation is antidepressant but not anxiolytic in rat models of anxiety and depression

  • Garth A. Hargreaves

      Affiliations

    • School of Psychiatry, University of New South Wales, Sydney, 2052, Australia
    • Neuropsychiatric Institute, Prince of Wales Hospital, Barker Street, Randwick, NSW 2031, Australia
    • ,
  • Iain S. McGregor

      Affiliations

    • School of Psychology, University of Sydney, Sydney, 2006, Australia
    • ,
  • Perminder S. Sachdev

      Affiliations

    • School of Psychiatry, University of New South Wales, Sydney, 2052, Australia
    • Neuropsychiatric Institute, Prince of Wales Hospital, Barker Street, Randwick, NSW 2031, Australia
    • Corresponding Author InformationCorresponding author. Neuropsychiatric Institute, Prince of Wales Hospital, Barker Street, Randwick, NSW 2031, Australia. Tel.: +61 2 93823763; fax +61 2 93823774.

Received 15 February 2005 ,Revised 17 June 2005 ,Accepted 15 July 2005.

References 

  1. Belmaker RH, Grisaru N. Magnetic stimulation of the brain in animal depression models responsive to ECS. Journal of ECT. 1998;14:194–205
  2. Ben-Shachar D, Gazawi H, Riboyad-Levin J, Klein E. Chronic repetitive transcranial magnetic stimulation alters beta-adrenergic and 5-HT2 receptor characteristics in rat brain. Brain Research. 1999;816:78–83
  3. Borsini F, Meli A. Is the forced swimming test a suitable model for revealing antidepressant activity?. Psychopharmacology. 1988;94:147–160
  4. Borsini F, Podhorna J, Marazziti D. Do animal models of anxiety predict anxiolytic-like effects of antidepressants?. Psychopharmacology. 2002;163:121–141
  5. Cryan JF, Lucki I. Antidepressant-like behavioural effects mediated by 5-hydroxytryptamine2C receptors. Journal of Pharmacology and Experimental Therapeutics. 2000;295:1120–1126
  6. Cryan JF, Markou A, Lucki I. Assessing antidepressant activity in rodents: recent developments and future needs. Trends in Pharmacological Sciences. 2002;23:238–245
  7. Czeh B, Welt T, Fischer AK, Erhardt A, Schmitt W, Muller MB, et al. Chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation: effects on stress hormone levels and adult hippocampal neurogenesis. Biological Psychiatry. 2002;52:1057–1065
  8. Detke MJ, Rickels M, Lucki I. Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology. 1995;121:66–72
  9. Dielenberg RA, McGregor IS. Defensive behavior in rats towards predatory odors: a review. Neuroscience and Biobehavioral Reviews. 2001;25:597–609
  10. Dielenberg RA, Arnold JC, McGregor IS. Low-dose midazolam attenuates predatory odor avoidance in rats. Pharmacology, Biochemistry and Behavior. 1999;62:197–201
  11. File SE, Seth P. A review of 25 years of the social interaction test. European Journal of Pharmacology. 2003;463:35–53
  12. Garcia-Toro M, Salva CollJ, Crespi Font M, Andres Tauler J, Aguirre Orue I, Bosch Calero C. Panic disorder and transcranial magnetic stimulation. Actas Españolas de Psiquiatria. 2002;30:221–224
  13. George MS, Wassermann EM, Kimbrell TA, Little JT, Williams WE, Danielson AL, et al. Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: a placebo-controlled crossover trial. American Journal of Psychiatry. 1997;154:1752–1756
  14. Grisaru N, Amir M, Cohen H, Kaplan Z. Effect of transcranial magnetic stimulation in posttraumatic stress disorder: a preliminary study. Biological Psychiatry. 1998;44:52–55
  15. Gur E, Lerer B, Dremencov E, Newman ME. Chronic repetitive transcranial magnetic stimulation induces subsensitivity of presynaptic serotonergic autoreceptor activity in rat brain. NeuroReport. 2000;11:2925–2929
  16. Hedges DW, Higginbotham BJ, Salyer DL, Lund TD. Transcranial magnetic stimulation effects on one-trial learning and response to anxiogenic stimuli in adult male rats. Journal of ECT. 2005;21:25–30
  17. Hedges DW, Massari C, Salyer DL, Lund TD, Hellewell JL, Johnson AC, et al. Duration of transcranial magnetic stimulation effects on the neuroendocrine stress response and coping behavior of adult male rats. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2003;27:633–638
  18. Hermelink D, Juckel G, Zwanzger P, Hampel H, Möller HJ, Padberg F. No evidence of lateralized effects on mood after slow repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers. European Neuropsychopharmacology. 2000;10:274
  19. Hoffman RE, Boutros NN, Hu S, Berman RM, Krystal JH, Charney DS. Transcranial magnetic stimulation and auditory hallucinations in schizophrenia. Lancet. 2000;355:1073–1075
  20. Hogg S. A review of the validity and variability of the elevated plus-maze as an animal model of anxiety. Pharmacology, Biochemistry and Behavior. 1996;54:21–30
  21. Howell DC. In: Statistical Methods for Psychology. 4th ed.. Belmont: Duxbury Press; 1997;
  22. Kanno M, Matsumoto M, Togashi H, Yoshioka M, Mano Y. Effects of repetitive transcranial magnetic stimulation on behavioral and neurochemical changes in rats during an elevated plus-maze test. Journal of the Neurological Sciences. 2003;211:5–14
  23. Keck ME, Engelmann M, Muller MB, Henniger MS, Hermann B, Rupprecht R, et al. Repetitive transcranial magnetic stimulation induces active coping strategies and attenuates the neuroendocrine stress response in rats. Journal of Psychiatric Research. 2000;34:265–276
  24. Keck ME, Welt T, Post A, Muller MB, Toschi N, Wigger A, et al. Neuroendocrine and behavioral effects of repetitive transcranial magnetic stimulation in a psychopathological animal model are suggestive of antidepressant-like effects. Neuropsychopharmacology. 2001;24:337–349
  25. Klein E, Kolsky Y, Puyerovsky M, Koren D, Chistyakov A, Feinsod M. Right prefrontal slow repetitive transcranial magnetic stimulation in schizophrenia: a double-blind sham-controlled pilot study. Biological Psychiatry. 1999;46:1451–1454
  26. Kole MH, Fuchs E, Ziemann U, Paulus W, Ebert U. Changes in 5-HT1A and NMDA binding sites by a single rapid transcranial magnetic stimulation procedure in rats. Brain Research. 1999;826:309–312
  27. Krahl SE, Senanayake SS, Pekary AE, Sattin A. Vagus nerve stimulation (VNS) is effective in a rat model of antidepressant action. Journal of Psychiatric Research. 2004;38:237–240
  28. Lucki I. The forced swimming test as a model for core and component behavioral effects of antidepressant drugs. Behavioral Pharmacology. 1997;8:523–532
  29. Martin JL, Barbanoj MJ, Perez V, Sacristan M. Transcranial magnetic stimulation for the treatment of obsessive–compulsive disorder. Cochrane Database of Systematic Reviews. 2003;(CD003387)
  30. McGregor IS. Using strawberry tree WorkbenchMac and Workbench PC software for data acquisition and control in the animal learning laboratory. Behavior Research Methods, Instruments, and Computers. 1996;28:38–48
  31. McGregor IS, Gurtman CG, Morley KC, Clemens KJ, Blokland A, Li KM, et al. Increased anxiety and “depressive” symptoms months after MDMA (“Ecstasy”) in rats: drug-induced hyperthermia does not predict long-term outcomes. Psychopharmacology. 2003;168:465–474
  32. Morley KC, McGregor IS. (+/−)-3,4-Methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) increases social interaction in rats. European Journal of Pharmacology. 2000;408:41–49
  33. Mosimann UP, Rihs TA, Engeler J, Fisch H, Schlaepfer TE. Mood effects of repetitive transcranial magnetic stimulation of left prefrontal cortex in healthy volunteers. Psychiatry Research. 2000;94:251–256
  34. Muller MB, Toschi N, Kresse AE, Post A, Keck ME. Long-term repetitive transcranial magnetic stimulation increases the expression of brain-derived neurotrophic factor and cholecystokinin mRNA, but not neuropeptide tyrosine mRNA in specific areas of rat brain. Neuropsychopharmacology. 2000;23:205–215
  35. Post A, Keck ME. Transcranial magnetic stimulation as a therapeutic tool in psychiatry: what do we know about the neurobiological mechanisms?. Journal of Psychiatric Research. 2001;35:193–215
  36. Sachdev PS, McBride R, Loo CK, Mitchell PB, Malhi GS, Croker VM. Right versus left prefrontal transcranial magnetic stimulation for obsessive–compulsive disorder: a preliminary investigation. Journal of Clinical Psychiatry. 2001;62:981–984
  37. Sachdev PS, McBride R, Loo C, Mitchell PM, Malhi GS, Croker V. Effects of different frequencies of transcranial magnetic stimulation (TMS) on the forced swim test model of depression in rats. Biological Psychiatry. 2002;51:474–479
  38. Wassermann EM, Lisanby SH. Therapeutic application of repetitive transcranial magnetic stimulation: a review. Clinical Neurophysiology. 2001;112:1367–1377
  39. Weissman JD, Epstein CM, Davey KR. Magnetic brain stimulation and brain size: relevance to animal studies. Electroencephalography and Clinical Neurophysiology. 1992;85:215–219

PII: S0165-1781(05)00207-6

doi: 10.1016/j.psychres.2005.07.008

Psychiatry Research
Volume 137, Issue 1 , Pages 113-121 , 15 November 2005

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