Changes in plasma amino acids after electroconvulsive therapy of depressed patients

Palmio, Johanna; Huuhka, Martti; Saransaari, Pirjo; Oja, Simo S.; Peltola, Jukka; Leinonen, Esa; Suhonen, Jaana; Keränen, Tapani

doi:10.1016/j.psychres.2005.07.010

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Volume 137, Issue 3 , Pages 183-190, 15 December 2005

Changes in plasma amino acids after electroconvulsive therapy of depressed patients

Johanna Palmio
- Department of Neurology, University of Tampere, FIN-33014, Tampere, Finland
- Department of Neurology, Tampere University Hospital, Tampere, Finland
- Corresponding author. Tel.: +358 3 355111; fax: +358 3 35516164.
Martti Huuhka
- Department of Psychiatry, Tampere University Hospital, Tampere, Finland
Pirjo Saransaari
- Brain Research Center, University of Tampere, Tampere, Finland
Simo S. Oja
- Brain Research Center, University of Tampere, Tampere, Finland
- Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
Jukka Peltola
- Department of Neurology, Tampere University Hospital, Tampere, Finland
Esa Leinonen
- Department of Psychiatry, Tampere University Hospital, Tampere, Finland
Jaana Suhonen
- Department of Neurology, Central Hospital, Jyväskylä, Finland
Tapani Keränen
- Department of Neurology, Tampere University Hospital, Tampere, Finland

Received 5 October 2004; received in revised form 1 July 2005; accepted 15 July 2005.

Abstract

There are indications that mood disorders may be related to perturbations in the amino acid transmitters. The amino acids may thus be targets of treatment of depression. The purpose of this pilot study was to measure the acute effects of a single administration of electroconvulsive therapy (ECT) on the plasma levels of amino acids in depressed patients. ECT was administered to 10 patients with major depressive disorder. Altogether 23 plasma amino acids were analyzed before and at 2, 6, 24 and 48 h after ECT. The levels of glutamate and aspartate increased at 6 h after ECT compared with the baseline. Also the levels of total tryptophan increased 2–24 h after ECT. There were also elevations in other amino acids at 6 and 24 h. The levels of gamma-aminobutyric acid (GABA) decreased at 2 h. In this study the acute effects of single ECT were associated with changes in the levels of glutamate, aspartate, GABA, tryptophan and some other amino acids. The preliminary data suggest that the therapeutic effects of ECT in depression may be due to mechanisms involving these amino acid transmitters.

Keywords: Depression, Electroconvulsive therapy, Aspartate, Glutamate, GABA, Tryptophan