Baseline level of platelet-leukocyte aggregates, platelet CD63 expression, and soluble P-selectin concentration in patientswith posttraumatic stress disorder: A pilot study

Vidović, Anđelko; Vilibić, Maja; Markotić, Alemka; Sabioncello, Ante; Gotovac, Katja; Folnegović-Šmalc, Vera; Dekaris, Dragan

doi:10.1016/j.psychres.2006.05.004

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Volume 150, Issue 2 , Pages 211-216, 30 March 2007

Baseline level of platelet-leukocyte aggregates, platelet CD63 expression, and soluble P-selectin concentration in patientswith posttraumatic stress disorder: A pilot study

Anđelko Vidović
- Department for Cellular Immunology, Institute of Immunology, Rockefellerova 10, HR-10 000 Zagreb, Croatia
- Corresponding author. Tel.: +385 1 4684 309; fax: +385 1 4684 303.
Maja Vilibić
- University Department of Psychiatry, Psychiatric Hospital Vrapče, Bolnička cesta 32, HR-10 090 Zagreb, Croatia
Alemka Markotić
- Department for Cellular Immunology, Institute of Immunology, Rockefellerova 10, HR-10 000 Zagreb, Croatia
Ante Sabioncello
- Department for Cellular Immunology, Institute of Immunology, Rockefellerova 10, HR-10 000 Zagreb, Croatia
Katja Gotovac
- Department for Cellular Immunology, Institute of Immunology, Rockefellerova 10, HR-10 000 Zagreb, Croatia
Vera Folnegović-Šmalc
- University Department of Psychiatry, Psychiatric Hospital Vrapče, Bolnička cesta 32, HR-10 090 Zagreb, Croatia
Dragan Dekaris
- Department for Cellular Immunology, Institute of Immunology, Rockefellerova 10, HR-10 000 Zagreb, Croatia

Received 4 January 2006; received in revised form 17 February 2006; accepted 3 May 2006.

Abstract

Platelets may have an important role in the development of cardiovascular disease (CVD) as a result of chronic stress. We conducted a pilot study to evaluate the effect of posttraumatic stress disorder (PTSD) on baseline platelet activation. Platelet-leukocyte aggregates (PLA) and CD63 expression were measured by flow cytometry, and soluble (s)P-selectin concentration was determined in sera of 20 Croatian male combat veterans with PTSD and 20 healthy civilians. Groups were matched in sex, age, body mass index (BMI) and traditional CVD risk factors. Our data showed no differences in measured parameters. Other platelet activation markers should be determined and a larger sample size used in future studies.

Keywords: War veterans, Cardiovascular disease, Flow cytometry