Psychiatry Research
Volume 157, Issue 1 , Pages 1-8 , 15 January 2008

Catechol-O-methyltransferase gene and obsessive–compulsive symptoms in patients with recent-onset schizophrenia: Preliminary results

  • Janneke Zinkstok

      Affiliations

    • Department of Psychiatry, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands
    • Neurogenetics Laboratory, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands
    • Corresponding Author InformationCorresponding author. Academic Medical Center, Department of Psychiatry, Tafelbergweg 25 (P1–146), 1105 BC Amsterdam, the Netherlands. Tel.: +31 20 5662240; fax: +31 20 5667072.
    • ,
  • Lonneke van Nimwegen

      Affiliations

    • Department of Psychiatry, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands
    • ,
  • Therese van Amelsvoort

      Affiliations

    • Department of Psychiatry, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands
    • ,
  • Lieuwe de Haan

      Affiliations

    • Department of Psychiatry, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands
    • ,
  • Maryan Abdulkadir Yusuf

      Affiliations

    • Department of Psychiatry, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands
    • ,
  • Frank Baas

      Affiliations

    • Neurogenetics Laboratory, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands
    • ,
  • Don Linszen

      Affiliations

    • Department of Psychiatry, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands

Received 28 April 2006 ,Revised 26 January 2007 ,Accepted 1 February 2007.

  • Image Result

    Y-BOCS scores in the 3 COMT genotype groups. Kruskal–Wallis showed a significant between-group difference in mean Y-BOCS scores (P=0.012). Y-BOCS scores in the Val/Val group were significantly higher

    Y-BOCS scores in the 3 COMT genotype groups. Kruskal–Wallis showed a significant between-group difference in mean Y-BOCS scores (P=0.012). Y-BOCS scores in the Val/Val group were significantly higher than those in the Met/Met group (P=0.01). Also, Y-BOCS scores in the Val/Met group were significantly higher than those with Met/Met genotype (P=0.034). There was a trend for a difference in Y-BOCS scores between the Val/Val and the Val/Met group (P=0.065).

☆ This study was presented in part at the Meeting of the Society of Biological Psychiatry, May 18–21, 2005, Atlanta, GA, USA, and at the Biennial Winter Workshop on Schizophrenia Research, 4th–10th February 2006, Davos, Switzerland.

PII: S0165-1781(07)00030-3

doi: 10.1016/j.psychres.2007.02.001

Psychiatry Research
Volume 157, Issue 1 , Pages 1-8 , 15 January 2008

Article Tools

* Image Usage & Resolution