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Volume 157, Issue 1 , Pages 9-19 , 15 January 2008

Inhibitory control and spatial working memory: A saccadic eye movement study of negative symptoms in schizophrenia

Caroline Winograd-Gurvich
- Experimental Neuropsychology Research Unit, School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, Victoria, 3800, Australia
- Brain Systems Research Laboratory, The Mental Health Research Institute, Parkville, Victoria, 3052, Australia
- Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University, School of Psychology, Psychiatry and Psychological Medicine, Prahran, Victoria, 3004, Australia
- Corresponding author. Experimental Neuropsychology Research Unit, School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, Victoria, 3800, Australia. Tel.: +61 3 9905 9448; fax: +61 3 9905 3948.
Paul B. Fitzgerald
- Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University, School of Psychology, Psychiatry and Psychological Medicine, Prahran, Victoria, 3004, Australia
Nellie Georgiou-Karistianis
- Experimental Neuropsychology Research Unit, School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, Victoria, 3800, Australia
Lyn Millist
- Brain Systems Research Laboratory, The Mental Health Research Institute, Parkville, Victoria, 3052, Australia
- Royal Melbourne Neurosciences, Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia
Owen White
- Experimental Neuropsychology Research Unit, School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, Victoria, 3800, Australia
- Brain Systems Research Laboratory, The Mental Health Research Institute, Parkville, Victoria, 3052, Australia
- Royal Melbourne Neurosciences, Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia

Received 15 May 2006 ,Revised 4 September 2006 ,Accepted 3 February 2007.

Schematic representations of saccade tasks showing stimuli on LCD screen alongside a time-line: (a) reflexive, visually guided task; (b) oddball task; (c) single memory-guided task; and (d) two-step m

Schematic representations of saccade tasks showing stimuli on LCD screen alongside a time-line: (a) reflexive, visually guided task; (b) oddball task; (c) single memory-guided task; and (d) two-step memory-guided task.
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Response suppression (% errors: inappropriate reflexive saccades to cues) for schizophrenia patients with high negative symptoms scores (high NS — filled); low negative symptoms scores (low NS — grey)

Response suppression (% errors: inappropriate reflexive saccades to cues) for schizophrenia patients with high negative symptoms scores (high NS — filled); low negative symptoms scores (low NS — grey) and; and controls (CON — white) in the fixation; saccade-engagement; single memory-guided and two-step memory-guided. Error bars are standard errors.
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