Psychiatry Research
Volume 157, Issue 1 , Pages 9-19 , 15 January 2008

Inhibitory control and spatial working memory: A saccadic eye movement study of negative symptoms in schizophrenia

  • Caroline Winograd-Gurvich

      Affiliations

    • Experimental Neuropsychology Research Unit, School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, Victoria, 3800, Australia
    • Brain Systems Research Laboratory, The Mental Health Research Institute, Parkville, Victoria, 3052, Australia
    • Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University, School of Psychology, Psychiatry and Psychological Medicine, Prahran, Victoria, 3004, Australia
    • Corresponding Author InformationCorresponding author. Experimental Neuropsychology Research Unit, School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, Victoria, 3800, Australia. Tel.: +61 3 9905 9448; fax: +61 3 9905 3948.
  • ,
  • Paul B. Fitzgerald

      Affiliations

    • Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University, School of Psychology, Psychiatry and Psychological Medicine, Prahran, Victoria, 3004, Australia
  • ,
  • Nellie Georgiou-Karistianis

      Affiliations

    • Experimental Neuropsychology Research Unit, School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, Victoria, 3800, Australia
  • ,
  • Lyn Millist

      Affiliations

    • Brain Systems Research Laboratory, The Mental Health Research Institute, Parkville, Victoria, 3052, Australia
    • Royal Melbourne Neurosciences, Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia
  • ,
  • Owen White

      Affiliations

    • Experimental Neuropsychology Research Unit, School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, Victoria, 3800, Australia
    • Brain Systems Research Laboratory, The Mental Health Research Institute, Parkville, Victoria, 3052, Australia
    • Royal Melbourne Neurosciences, Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia

Received 15 May 2006 ,Revised 4 September 2006 ,Accepted 3 February 2007.

References 

  1. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders, 4th ed., TR. Washington DC: APA; 2000;
  2. Andreasen NC. Scale for the Assessment of Negative Symptoms (SANS). Iowa City, IA: University of Iowa; 1984;
  3. Andreasen NC, Olsen S. Negative vs positive schizophrenia. Archives of General Psychiatry. 1982;39:789–794
  4. Apicella P, Scarnati E, Ljungberg T, Schultz W. Neuronal activity in monkey striatum related to the expectation of predictable environmental events. Journal of Neurophysiology. 1992;68:945–960
  5. Berman I, Viegner B, Merson A, Allan E, Pappas D, Green AI. Differential relationships between positive and negative symptoms and neuropsychological deficits in schizophrenia. Schizophrenia Research. 1997;25:1–10
  6. Broerse A, Crawford TJ, den Boer JA. Parsing cognition in schizophrenia using saccadic eye movements: a selective overview. Neuropsychologia. 2001;39:742–756
  7. Burke JG, Reveley MA. Improved antisaccade performance with risperidone in schizophrenia. Journal of Neurology, Neurosurgery and Psychiatry. 2002;72:449–454
  8. Caligiuri MP, Lohr JB, Ruck RK. Scaling of movement velocity: a measure of neuromotor retardation in individuals with psychopathology. Psychophysiology. 1998;35:431–437
  9. Clementz BA. The ability to produce express saccades as a function of gap interval among schizophrenia patients. Experimental Brain Research. 1996;111:121–130
  10. Clementz BA. Psychophysiological measures of (dis)inhibition as liability indicators for schizophrenia. Psychophysiology. 1998;35:648–668
  11. Ettinger U, Kumari V, Chitnis XA, Corr PJ, Crawford TJ, Fannon DG, et al. Volumetric neural correlates of antisaccade eye movements in first-episode psychosis. American Journal of Psychiatry. 2004;161:1918–1921
  12. Ettinger U, Picchioni M, Hall MH, Schulze K, Toulopoulou T, Landau S, et al. Antisaccade performance in monozygotic twins discordant for schizophrenia: the Maudsley twin study. American Journal of Psychiatry. 2006;163:543–545
  13. Fischer B, Ramsperger E. Human express saccades: extremely short reaction times of goal directed eye movements. Experimental Brain Research. 1984;57:191–195
  14. Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research. 1975;12:189–198
  15. Fuster JM. The prefrontal cortex and temporal integration. In:  Jones EG,  Peter A editor. Association and Auditory Cortices. Cerebral Cortex. vol. 4:New York: Plenum; 1985;p. 151–177
  16. Fuster JM. The Prefrontal Cortex: Anatomy, Physiology, and Neuropsychology of the Frontal Lobe. 3rd ed.. New York: Plenum; 1997;
  17. Goldman-Rakic PS. Circuitry of primate prefrontal cortex and regulation of behaviour by representational memory. In:  Mount-Castle VB editors. Handbook of Physiology, Section 1. vol. 5:Bethesda: American Physiological Society; 1987;p. 373–417
  18. Guy W. ECDUE Assessment Manual for Psychopharmacology. Rockville: National Institute of Mental Health; 1976;
  19. Hammer MA, Katsanis J, Iacono WG. The relationship between negative symptoms and neuropsychological performance. Biological Psychiatry. 1995;37:828–830
  20. Hikosaka O, Takikawa Y, Kawagoe R. Role of the basal ganglia in the control of purposive saccadic eye movements. Physiology Review. 2000;80:953–978
  21. Hutton SB, Joyce EM, Barnes TRE, Kennard C. Saccadic distractibility in first-episode schizophrenia. Neuropsychologia. 2002;40:1729–1736
  22. Izawa Y, Suzuki H, Shinoda Y. Suppression of visually and memory-guided saccades induced by electrical stimulation of the monkey frontal eye field. I. Suppression of ipsilateral saccades. Journal of Neurophysiology. 2004;92:2248–2260
  23. Izawa Y, Suzuki H, Shinoda Y. Suppression of visually and memory-guided saccades induced by electrical stimulation of the monkey frontal eye field. II. Suppression of bilateral saccades. Journal of Neurophysiology. 2004;92:2261–2273
  24. Jogems-Kosterman BJM, Zitman F, Van Hoof JJM, Hulstijn W. Psychomotor slowing and planning deficits in schizophrenia. Schizophrenia Research. 2001;48:317–333
  25. Karn KS, Moller P, Hayhoe MM. Reference frames in saccade targeting. Experimental Brain Research. 1997;115:267–282
  26. Karoumi B, Ventre-Dominey J, Dalery J. Predictive saccade behaviour is enhanced in schizophrenia. Cognition. 1998;68:B81–B91
  27. Kay SR, Fiszbein A, Opler LE. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin. 1987;13:261–275
  28. Kraepelin E. Dementia Praecox and Paraphrenia. New York: Robert E Krieger Publishing Co. Inc.; 1919/1971;
  29. Leigh RJ, Zee DS. The Neurology of Eye Movements. 3rd ed.. New York: Oxford University Press; 1999;
  30. McDowell JE, Blumenfeld LD, Clementz BA. Fast reaction time predictive saccades among schizophrenia may be consistent with a failure of inhibition. Schizophrenia Research. 1997;24:243
  31. McDowell JE, Clementz BA. Behavioral and brain imaging studies of saccadic performance in schizophrenia. Biological Psychiatry. 2001;57:5–22
  32. McDowell JE, Clementz BA, Wixted JT. Timing and amplitude of saccades during predictive saccadic tracking in schizophrenia. Psychophysiology. 1996;33:93–101
  33. McGlashan TH, Fenton WS. The positive–negative distinction in schizophrenia: a review of natural history validators. Archives of General Psychiatry. 1992;49:63–72
  34. Montgomery SA, Åsberg M. A new depression scale designed to be sensitive to change. British Journal of Psychiatry. 1979;134:382–389
  35. Nelson HE. The National Adult Reading Test (NART): Test Manual. Windsor: NFER-NELSON; 1982;
  36. Nkam I, Thibaut F, Denise P, Van Der Elst A, Ségard L, Brazo P, et al. Saccadic and smooth-pursuit eye movements in deficit and non-deficit schizophrenia. Schizophrenia Research. 2001;48:145–153
  37. Peralta V, Cuesta MJ. Symptoms of the schizophrenic negative syndrome. British Journal of Psychiatry. 1996;169:209–212
  38. Peralta V, de Leon J, Cuesta MJ. Are there more than two syndromes in schizophrenia? A critique of the positive–negative dichotomy. British Journal of Psychiatry. 1992;161:335–343
  39. Pierrot-Deseilligny C, Rivaud S, Gaymard B, Müri R, Vermersch A. Cortical control of saccades. Annals of Neurology. 1995;37:557–567
  40. Ploner CJ, Rivaud-Pechoux S, Gaymard BM, Agid Y, Pierrot-Deseilligny C. Errors of memory-guided saccades in humans with lesions of the frontal eye field and the dorsolateral prefrontal cortex. Journal of Neurophysiology. 1999;82:1086–1090
  41. Rodríguez VM, Andrée RM, Castejón JP, Labradorm RG, Navarrete FF, Delgado LC, et al. Cerebral perfusion correlates of negative symptomatology and parkinsonism in a sample of treatment-refractory schizophrenics: an exploratory 99m Tc-HMPAO SPET study. Schizophrenia Research. 1997;25:11–20
  42. Sanfilipo M, Lafargue T, Rusinek H, Arena L, Loneragan C, Lautin A, et al. Volumetric measure of the frontal and temporal lobe regions in schizophrenia: relationship to negative symptoms. Archives of General Psychiatry. 2000;57:471–480
  43. Schultz W, Apicella P, Scarnati E, Ljungberg T. Neuronal activity in monkey ventral striatum related to the expectation of reward. Journal of Neuroscience. 1992;12:4595–4610
  44. Simpson GM, Angus JWS. Drug induced extrapyramidal disorders: controlled studies of the relationship between behavioural change and the extrapyramisal symptoms produced by psychotropic drugs. Acta Psychiatrica Scandinavica. Supplementum. 1970;212:11–19
  45. Spengler D, Trillenberg P, Sprenger A, Nagel M, Kordon A, Junghanns K, et al. Evidence from increased anticipation of predictive saccades for a dysfunction of fronto-striatal circuits in obsessive–compulsive disorder. Psychiatry Research. 2006;143:77–88
  46. Sweeney JA, Bauer KS, Keshavan MS, Haas GL, Schooler NR, Kroboth PD. Adverse effects of risperidone on eye movement activity: a comparison of risperidone and haloperidol in antipsychotic-naive schizophrenic patients. Neuropsychopharmacology. 1997;16:217–228
  47. Takahashi M, Sugiuchi Y, Izawa Y, Shinoda Y. Synaptic inputs and their pathways from fixation and saccade zones of the superior colliculus to inhibitory burst neurons and pause neurons. Annals of the New York Academy of Sciences. 2005;1039:209–219
  48. Tien AY, Ross DE, Pearlson G, Strauss ME. Eye movements and psychopathology in schizophrenia and bipolar disorder. Journal of Nervous and Mental Disease. 1996;184:331–338
  49. Wible CG, Anderson J, Shenton ME, Kricun A, Hirayasu Y, Tanaka S, et al. Prefrontal cortex, negative symptoms, and schizophrenia: an MRI study. Psychiatry Research. Neuroimaging. 2001;108:65–78
  50. Winograd-Gurvich C, Georgiou-Karistianis N, Fitzgerald PB, Millist L, White OB. Ocular motor differences between melancholic and non-melancholic depression. Journal of Affective Disorders. 2006;93:193–203

PII: S0165-1781(07)00034-0

doi: 10.1016/j.psychres.2007.02.004

Psychiatry Research
Volume 157, Issue 1 , Pages 9-19 , 15 January 2008