Psychiatry Research
Volume 159, Issue 1 , Pages 133-139 , 30 May 2008

Comparison of clinical characteristics, co-morbidity and pharmacotherapy in adolescent schizophrenia patients with and without obsessive–compulsive disorder

  • Michael Poyurovsky

      Affiliations

    • Tirat Carmel Mental Health Center, Tirat Carmel, Israel
    • Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    • Corresponding Author InformationCorresponding author. Tirat Carmel Mental Health Center, POB 9, Tirat Carmel 30200, Israel. Tel.: +972 4 8559349; fax: +972 4 8559330.
  • ,
  • Sarit Faragian

      Affiliations

    • Tirat Carmel Mental Health Center, Tirat Carmel, Israel
  • ,
  • Adeeb Shabeta

      Affiliations

    • Tirat Carmel Mental Health Center, Tirat Carmel, Israel
  • ,
  • Anatoly Kosov

      Affiliations

    • Tirat Carmel Mental Health Center, Tirat Carmel, Israel

Received 11 March 2007 ,Revised 2 June 2007 ,Accepted 12 June 2007.

References 

  1. Andreasen NC. Scale for the Assessment of Negative Symptoms (SANS). Iowa City: University of Iowa; 1983;
  2. Andreasen NC. Scale for the Assessment of Positive Symptoms (SAPS). Iowa City: University of Iowa; 1984;
  3. Berman I, Viegner B, Merson A, Allan E, Pappas D, Green AI. Differential relationships between positive and negative symptoms and neuropsychological deficits in schizophrenia. Schizophrenia Research. 1997;25:1–10
  4. Berman I, Merson A, Viegner B, Losonczy MF, Pappas D, Green AI. Obsessions and compulsions as a distinct cluster of symptoms in schizophrenia: a neuropsychological study. Journal of Nervous and Mental Disease. 1998;186:150–156
  5. Bermanzohn PC, Porto L, Arlow PB, Axelrod S, Sastry G, Stronger R, et al. Are some neuroleptic-refractory symptoms of schizophrenia really obsessions?. CNS Spectrums. 1997;2:51–57
  6. Bermanzohn PC, Porto L, Arlow PB, Pollack S, Stronger R, Siris SG. Hierarchical diagnosis in chronic schizophrenia: a clinical study of co-occuring syndromes. Schizophrenia Bulletin. 2000;26:517–525
  7. Byerly M, Goodman W, Acholonu W, Bugno R, Rush AJ. Obsessive–compulsive symptoms in schizophrenia: frequency and clinical features. Schizophrenia Research. 2005;76:309–316
  8. de Haan L, Hoogenboom B, Beuk N, van Amelsvoort T, Linszen D. Obsessive–compulsive symptoms and positive, negative, and depressive symptoms in patients with recent-onset schizophrenic disorders. Canadian Journal of Psychiatry. 2005;50:519–524
  9. Fenton WS, McGlashan TH. The prognostic significance of obsessive–compulsive symptoms in schizophrenia. American Journal of Psychiatry. 1986;143:437–441
  10. First MB, Spitzer RL, Gibbon M. Structural Clinical Interview for DSM-IV Axis I Disorders, Patient Edition (SCID-I/P, Version 2.0). New York, NY: Biometric Research, New York State Psychiatric Institute; 1995;
  11. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, et al. The Yale–Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Archives of General Psychiatry. 1989;46:1006–1011
  12. Green AI, Canuso CM, Brenner MJ, Wojcik JD. Detection and management of comorbidity in patients with schizophrenia. Psychiatric Clinics of North America. 2003;26:15–139
  13. Guy W. ECDE Assessment Manual for Psychopharmacology. Revised DHEW Pub (ADM). Rockville, MD: National Institute of Mental Health; 1976;
  14. Hollander E, Benzaquen SD. The obsessive–compulsive spectrum disorders. International Review of Psychiatry. 1997;9:99–109
  15. Hollis C. Adolescent schizophrenia. Advances in Psychiatric Treatment. 2000;6:83–92
  16. Hwang MY, Opler LA. Management of schizophrenia with obsessive–compulsive disorder. Psychiatric Annals. 2000;30:23–28
  17. Jablensky A. Subtyping schizophrenia: implications for genetic research. Molecular Psychiatry. 2006;11:815–836
  18. Lykouras L, Alevizos B, Michalopoulou P, Rabavilas A. Obsessive–compulsive symptoms induced by atypical antipsychotics. A review of the reported cases. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2003;27:333–346
  19. Lysaker PH, Marks KA, Picone JB, Rollins AL, Fastenau PS, Bond GR. Obsessive and compulsive symptoms in schizophrenia: clinical and neurocognitive correlates. Journal of Nervous and Mental Disease. 2000;188:78–83
  20. Lysaker PH, Bryson GJ, Marks KA, Greig TC, Bell MD. Association of obsessions and compulsions in schizophrenia with neurocognition and negative symptoms. Journal of Neuropsychiatry and Clinical Neurosciences. 2002;14:449–453
  21. Lysaker PH, Lancaster RS, Nees MA, Davis LW. Patterns of obsessive–compulsive symptoms and social function in schizophrenia. Psychiatry Research. 2004;125:139–146
  22. McElroy SL, Phillips KA, Keck PE. Obsessive–compulsive spectrum disorders. Journal of Clinical Psychiatry. 1994;55(10, suppl):33–51
  23. Nechmad A, Ratzoni G, Poyurovsky M, Meged S, Avidan G, Fuchs C, et al. Obsessive–compulsive disorder in adolescent schizophrenia patients. American Journal of Psychiatry. 2003;160:1002–1004
  24. Nicolson R, Lenane M, Hamburger SD, Fernandez T, Bedwell J, Rapoport JL. Lessons from childhood-onset schizophrenia. Brain Research Reviews. 2000;31:147–156
  25. Ohta M, Kokai M, Morita Y. Features of obsessive–compulsive disorder in patients primarily diagnosed with schizophrenia. Psychiatry and Clinical Neurosciences. 2003;57:67–74
  26. Ongur D, Goff D. Obsessive–compulsive symptoms in schizophrenia: associated clinical features, cognitive function and medication status. Schizophrenia Research. 2005;75:349–362
  27. Phillips KA, McElroy SL, Keck PE, Hudson JI, Pope HG. A comparison of delusional and non-delusional body dysmorphic disorder in 100 cases. Psychopharmacology Bulletin. 1994;30:179–186
  28. Poyurovsky M, Fuchs C, Weizman A. Obsessive–compulsive disorder in patients with first-episode schizophrenia. American Journal Psychiatry. 1999;156:1998–2000
  29. Poyurovsky M, Hramenkov S, Isakov V, Rauchverger B, Modai I, Schneidman M, et al. Obsessive–compulsive disorder in hospitalized patients with chronic schizophrenia. Psychiatry Research. 2001;102:49–57
  30. Poyurovsky M, Kriss V, Weisman G, Faragian S, Kurs R, Schneidman M, et al. Comparison of clinical characteristics and comorbidity in schizophrenia patients with and without obsessive–compulsive disorder: schizophrenic and OC symptoms in schizophrenia. Journal of Clinical Psychiatry. 2003;64:1300–1307
  31. Poyurovsky M, Weizman A, Weizman R. Obsessive–compulsive disorder in schizophrenia: clinical characteristics and treatment. CNS Drugs. 2004;18:989–1010
  32. Poyurovsky M, Kriss V, Weisman G, Faragian S, Schneidman M, Fuchs C, et al. Familial aggregation of schizophrenia-spectrum disorders and obsessive–compulsive associated disorders in schizophrenia probands with and without OCD. American Journal of Medical Genetics B Neuropsychiatric Genetics. 2005;133:31–36
  33. Poyurovsky M, Fuchs C, Faragian S, Kriss V, Weisman G, Pashinian A, et al. Preferential aggregation of obsessive–compulsive spectrum disorders in schizophrenia patients with obsessive–compulsive disorder. Canadian Journal of Psychiatry. 2006;51:746–754
  34. Sareen J, Kirshner A, Lander M, Kjernisted KD, Eleff MK, Reiss JP. Do antipsychotics ameliorate or exacerbate obsessive–compulsive disorder symptoms? A systematic review. Journal of Affective Disorders. 2004;82:167–174
  35. Sasson Y, Zohar J, Chopra M, Lustig M, Iancu I, Hendler T. Epidemiology of obsessive–compulsive disorder: a world view. Journal of Clinical Psychiatry. 1997;58(12, suppl):7–10
  36. Sevincok L, Akoglu A, Arslantas H. Schizo-obsessive and obsessive–compulsive disorder: comparison of clinical characteristics and neurological soft signs. Psychiatry Research. 2006;145:241–248
  37. Sobin C, Blundell ML, Karayiorgou M. Phenotypical differences in early- and late-onset obsessive–compulsive disorder. Comprehensive Psychiatry. 2000;41:373–379
  38. Tibbo P, Kroetsch M, Chue P, Warneke L. Obsessive–compulsive disorder in schizophrenia. Journal of Psychiatric Research. 2000;34:139–146
  39. Zohar J. Is there room for a new diagnostic subtype: the schizo-obsessive subtype?. CNS Spectrums. 1997;23:49–50

PII: S0165-1781(07)00192-8

doi: 10.1016/j.psychres.2007.06.010

Psychiatry Research
Volume 159, Issue 1 , Pages 133-139 , 30 May 2008