Psychiatry Research
Volume 166, Issue 2 , Pages 174-183 , 30 April 2009

Time perception and its neuropsychological correlates in patients with schizophrenia and in healthy volunteers

  • Kwang-Hyuk Lee

      Affiliations

    • Corresponding Author InformationCorresponding author. Sheffield Cognition and Neuroimaging Laboratory (SCANLab), Academic Clinical Psychiatry, Section of Neuroscience, School of Medicine, University of Sheffield, The Longley Centre, Norwood Grange Drive Sheffield, S5 7JT, United Kingdom. Tel.: +44 114 226 1501; fax: +44 114 226 1522.
    • These authors made an equal contribution to the article.
  • ,
  • Rajinder S. Bhaker

      Affiliations

    • These authors made an equal contribution to the article.
  • ,
  • Ashok Mysore
  • ,
  • Randolph W. Parks
  • ,
  • Paul B.L. Birkett
  • ,
  • Peter W.R. Woodruff

Received 20 November 2006 ,Revised 19 October 2007 ,Accepted 2 March 2008.

References 

  1. Andreasen NC. Scale for the Assessment of Negative Symptoms (SANS). Iowa City: University of Iowa; 1983;
  2. Andreasen NC. Scale for the Assessment of Positive Symptoms (SAPS). Iowa City: University of Iowa; 1984;
  3. Andreasen NC, Nopoulos P, O'Leary DS, Miller DD, Wassink T, Flaum M. Defining the phenotype of schizophrenia: cognitive dysmetria and its neural mechanisms. Biological Psychiatry. 1999;46:908–920
  4. Angle HV. Role of chlorpromazine in maintaining timing behavior in chronic schizophrenics. Psychopharmacologia. 1973;28:185–194
  5. Brandt J, Benedict RHB. Hopkins Verbal Learning Test-revised. Professional Manual. Florida: Psychological Assessment Resources; 1991;
  6. Chen WJ, Hsiao CK, Lin CC. Schizotypy in community samples: the three-factor structure and correlation with sustained attention. Journal of Abnormal Psychology. 1997;106:649–654
  7. Cohen JD, MacWhinney B, Flatt M, Provost J. PsyScope: a new graphic interactive environment for designing psychology experiments. Behavioral Research Methods, Instruments, and Computers. 1993;25:257–271
  8. Clegg J, Brumfitt S, Parks RW, Woodruff PW. Speech and language therapy intervention in schizophrenia: a case study. International Journal of Language and Communication Disorders. 2007;42:81–101
  9. Davalos DB, Kisley MA, Freedman R. Behavioral and electrophysiological indices of temporal processing dysfunction in schizophrenia. Journal of Neuropsychiatry and Clinical Neurosciences. 2005;17:517–525
  10. Davalos DB, Kisley MA, Ross RG. Deficits in auditory and visual temporal perception in schizophrenia. Cognitive Neuropsychiatry. 2002;7:273–282
  11. Davis KL, Kahn RS, Ko G, Davidson M. Dopamine in schizophrenia: a review and reconceptualization. American Journal of Psychiatry. 1991;148:1474–1486
  12. Droit-Volet S, Wearden J. Speeding up an internal clock in children? Effects of visual flicker on subjective duration.. The Quarterly Journal of Experimental Psychology. B, Comparative and Physiological Psychology. 2002;55:193–211
  13. Elvevåg B, McCormack T, Gilbert A, Brown GD, Weinberger DR, Goldberg TE. Duration judgements in patients with schizophrenia. Psychological Medicine. 2003;33:1249–1261
  14. Fioravanti M, Carlone O, Vitale B, Cinti ME, Clare L. A meta-analysis of cognitive deficits in adults with a diagnosis of schizophrenia. Neuropsychology review. 2005;15:73–95
  15. Franck N, Posada A, Pichon S, Haggard P. Altered subjective time of events in schizophrenia. Journal of Nervous and Mental Disease. 2005;193:350–353
  16. Freedman BJ. The subjective experience of perceptual and cognitive disturbances in schizophrenia. A review of autobiographical accounts. Archives of General Psychiatry. 1974;30:333–340
  17. Gibbon J, Church RM. Representation of time. Cognition. 1990;37:23–54
  18. Gibbon J, Malapani C, Dale CL, Gallistel C. Toward a neurobiology of temporal cognition: advances and challenges. Current Opinion in Neurobiology. 1997;7:170–184
  19. Gisiger T. Scale invariance in biology: coincidence or footprint of a universal mechanism?. Biological Reviews of the Cambridge Philosophical Society. 2001;76:161–209
  20. Goldstone S, Nurnberg HG, Lhamon WT. Effects of trifluoperazine, chlorpromazine, and haloperidol upon temporal information processing by schizophrenic patients. Psychopharmacology (Berl). 1979;65:119–124
  21. Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology. 1998;12:426–445
  22. Hyams, D.G. Curve Expert 1.3, http://curveexpert.webhop.biz/, Hixson, TN, USA.
  23. Ivry RB, Spencer RM. The neural representation of time. Current Opinion in Neurobiology. 2004;14:225–232
  24. Kongs SK, Thompson LL, Iverson GI, Heaton RK. Wisconsin Card Sorting Test-64 Card Version (WCST-64). Lutz, Florida: PAR Assessment Resources; 2000;
  25. Lee K-H, Egleston PN, Brown WH, Gregory AN, Barker AT, Woodruff PW. The role of the cerebellum in subsecond time perception: evidence from repetitive transcranial magnetic stimulation. Journal of Cognitive Neuroscience. 2007;19:147–157
  26. Lee K-H, Farrow TF, Parks RW, Newton L, Mir N, Egleston PN, et al. Increased cerebellar vermis white-matter volume in men with schizophrenia. Journal of Psychiatric Research. 2007;41:645–651
  27. Lejeune H. Switching or gating? The attentional challenge in cognitive models of psychological time. Behavioural Processes. 1998;44:127–145
  28. Lewis A. The experience of time in mental disorder. Proceedings of the Royal Society of Medicine. 1932;25:611–620
  29. Lewis PA, Miall RC. Brain activation patterns during measurement of sub- and supra-second intervals. Neuropsychologia. 2003;41:1583–1592
  30. Liu SK, Chiu CH, Chang CJ, Hwang TJ, Hwu HG, Chen WJ. Deficits in sustained attention in schizophrenia and affective disorders: stable versus state-dependent markers. American Journal of Psychiatry. 2002;159:975–982
  31. Malapani C. Scalar timing in animals and humans. Learning and Motivation. 2002;33:156–176
  32. Maricq AV, Church RM. The differential effects of haloperidol and methamphetamine on time estimation in the rat. Psychopharmacology (Berl). 1983;79:10–15
  33. Maricq AV, Roberts S, Church RM. Methamphetamine and time estimation. Journal of Experimental Psychology: Animal Behavior Processes. 1981;7:18–30
  34. Matell MS, Meck WH. Cortico-striatal circuits and interval timing: coincidence detection of oscillatory processes. Brain Research. Cognitive Brain Research. 2004;21:139–170
  35. Meck WH. Affinity for the dopamine D2 receptor predicts neuroleptic potency in decreasing the speed of an internal clock. Pharmacology, Biochemistry, and Behavior. 1986;25:1185–1189
  36. Meck WH. Neuropharmacology of timing and time perception. Brain Research. Cognitive Brain Research. 1996;3:227–242
  37. Melges FT, Fougerousse JCE. Time sense, emotions, and acute mental illness. Journal of Psychiatric Research. 1966;4:127–140
  38. Näätänen R, Syssoeva O, Takegata R. Automatic time perception in the human brain for intervals ranging from milliseconds to seconds. Psychophysiology. 2004;41:660–663
  39. Nieder A, Miller EK. Coding of cognitive magnitude: compressed scaling of numerical information in the primate prefrontal cortex. Neuron. 2003;37:149–157
  40. Pearl D, Berg PSD. Time perception and conflict arousal in schizophrenia. Journal of Abnormal and Social Psychology. 1963;66:332–338
  41. Rabin AI. Time estimation of schizophrenics and non-psychotics. Journal of Clinical Psychology. 1957;13:88–90
  42. Rammsayer T. Temporal discrimination in schizophrenic and affective disorders: evidence for a dopamine-dependent internal clock. The International Journal of Neuroscience. 1990;53:111–120
  43. Seidman LJ, Caplan BB, Tolomiczenko GS, Turner WM, Penk WE, Schutt RK, et al. Neuropsychological function in homeless mentally ill individuals. Journal of Nervous and Mental Disease. 1997;185:3–12
  44. Sims A. Symptoms in the Mind: An Introduction to Descriptive Psychopathology. 2nd ed.. London: W. B. Saunders Company LTD; 1995;
  45. Tracy JI, Monaco C, McMichael H, Tyson K, Chambliss C, Christensen HL, et al. Information-processing characteristics of explicit time estimation by patients with schizophrenia and normal controls. Perceptual and Motor Skills. 1998;86:515–526
  46. Tysk L. A longitudinal study of time estimation in psychotic disorders. Perceptual and Motor Skills. 1984;59:779–789
  47. Volz HP, Nenadic I, Gaser C, Rammsayer T, Hager F, Sauer H. Time estimation in schizophrenia: an fMRI study at adjusted levels of difficulty. Neuroreport. 2001;12:313–316
  48. Wearden JH. “Beyond the fields we know...”: exploring and developing scalar timing theory. Behavioural Processes. 1999;45:3–21
  49. Wearden JH, Pilkington R, Carter E. ‘Subjective lengthening’ during repeated testing of a simple temporal discrimination. Behavioural Processes. 1999;46:25–38
  50. Weinstein AD, Goldstone S, Boardman WK. The effect of recent and remote frames of reference on temporal judgments of schizophrenic patients. Journal of Abnormal and Social Psychology. 1958;57:241–244
  51. Wichmann FA, Hill NJ. The psychometric function: I. Fitting, sampling, and goodness of fit. Perception & Psychophysics. 2001;63:1293–1313
  52. Zakay D. The evasive art of subjective time measurement: Some methodological dilemmas. In:  Block RA editors. Cognitive Models of Psychological Time. Hillsdale, NJ: Lawrence Erlbaum Associates; 1990;p. 59–84

PII: S0165-1781(08)00065-6

doi: 10.1016/j.psychres.2008.03.004

Psychiatry Research
Volume 166, Issue 2 , Pages 174-183 , 30 April 2009