Psychiatry Research
Volume 169, Issue 2 , Pages 113-117 , 30 September 2009

Haplotype analysis of single nucleotide polymorphisms in the vascular endothelial growth factor (VEGFA) gene and antidepressant treatment response in major depressive disorder

  • Shih-Jen Tsai

      Affiliations

    • Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
    • Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Shih-Pai Road, Sec. 2, 11217, Taipei, Taiwan. Tel.: +886 2 2875 7027x267; fax: +886 2 2872 5643.
  • ,
  • Chen-Jee Hong

      Affiliations

    • Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
    • Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    • Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan
  • ,
  • Ying-Jay Liou

      Affiliations

    • Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
    • Department of Psychiatry, Yuli Veterans Hospital, Hualien, Taiwan
    • Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
  • ,
  • Tai-Jui Chen

      Affiliations

    • Department of Psychiatry, E-DA Hospital and I-Shou University, Kaohsiung, Taiwan
  • ,
  • Mao-Liang Chen

      Affiliations

    • Department of Psychiatry, Yuli Veterans Hospital, Hualien, Taiwan
  • ,
  • Sheue-Jane Hou

      Affiliations

    • Division of Psychiatry, Cheng-Hsin Rehabilitation and Medical Center, Taipei, Taiwan
  • ,
  • Feng-Chang Yen

      Affiliations

    • Division of Psychiatry, Cheng-Hsin Rehabilitation and Medical Center, Taipei, Taiwan
  • ,
  • Younger W.-Y. Yu

      Affiliations

    • Yu's Psychiatric Clinic, Kaohsiung, Taiwan

Received 28 January 2008 ,Revised 15 May 2008 ,Accepted 12 June 2008.

References 

  1. Burke WJ, Hendricks SE, McArthur-Campbell D, Jacques D, Stull T. Fluoxetine and norfluoxetine serum concentrations and clinical response in weekly versus daily dosing. Psychopharmacology Bulletin. 1996;32:27–32
  2. Cassano P, Fava M. Depression and public health: an overview. Journal of Psychosomatic Research. 2002;53:849–857
  3. Duman RS, Heninger GR, Nestler EJ. A molecular and cellular theory of depression. Archives of General Psychiatry. 1997;54:597–606
  4. Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochemical and Biophysical Research Communications. 1989;161:851–858
  5. Hamilton M. Development of a rating scale for primary depressive illness. The British Journal of Social and Clinical Psychology. 1967;6:278–296
  6. Iga J, Ueno S, Yamauchi K, Numata S, Tayoshi-Shibuya S, Kinouchi S, et al. Gene expression and association analysis of vascular endothelial growth factor in major depressive disorder. Progress in Neuro-psychopharmacology & Biological Psychiatry. 2007;31:658–663
  7. Lambrechts D, Storkebaum E, Morimoto M, Del-Favero J, Desmet F, Marklund SL, et al. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nature Genetics. 2003;34:383–394
  8. Newton SS, Collier EF, Hunsberger J, Adams D, Terwilliger R, Selvanayagam E, et al. Gene profile of electroconvulsive seizures: induction of neurotrophic and angiogenic factors. The Journal of Neuroscience. 2003;23:10841–10851
  9. O'Reilly RL, Bogue L, Singh SM. Pharmacogenetic response to antidepressants in a multicase family with affective disorder. Biological Psychiatry. 1994;36:467–471
  10. Pare CM, Mack JW. Differentiation of two genetically specific types of depression by the response to antidepressant drugs. Journal of Medical Genetics. 1971;8:306–309
  11. Rausch JL, Johnson ME, Fei YJ, Li JQ, Shendarkar N, Hobby HM, et al. Initial conditions of serotonin transporter kinetics and genotype: influence on SSRI treatment trial outcome. Biological Psychiatry. 2002;51:723–732
  12. Smeraldi E, Zanardi R, Benedetti F, Di Bella D, Perez J, Catalano M. Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Molecular Psychiatry. 1998;3:508–511
  13. Storkebaum E, Lambrechts D, Carmeliet P. VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection. BioEssays. 2004;26:943–954
  14. Sun Y, Jin K, Xie L, Childs J, Mao XO, Logvinova A, et al. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. The Journal of Clinical Investigation. 2003;111:1843–1851
  15. Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, et al. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. The Journal of Biological Chemistry. 1991;266:11947–11954
  16. Tsai SJ, Hong CJ. Pharmacogenetics of selective serotonin reuptake inhibitor response in major depression. Current Pharmacogenomics. 2003;1:1–7
  17. Virgintino D, Errede M, Robertson D, Girolamo F, Masciandaro A, Bertossi M. VEGF expression is developmentally regulated during human brain angiogenesis. Histochemistry and Cell Biology. 2003;119:227–232
  18. Warner-Schmidt JL, Duman RS. VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants. Proceedings of the National Academy of Sciences of the United States of America. 2007;104:4647–4652
  19. Xie J, Yi L, Xu ZF, Mo XM, Hu YL, Wang DJ, et al. VEGF C-634G polymorphism is associated with protection from isolated ventricular septal defect: case–control and TDT studies. European Journal of Human Genetics. 2007;15:1246–1251
  20. Yu YW, Tsai SJ, Chen TJ, Lin CH, Hong CJ. Association study of the serotonin transporter promoter polymorphism and symptomatology and antidepressant response in major depressive disorders. Molecular Psychiatry. 2002;7:1115–1119

PII: S0165-1781(08)00195-9

doi: 10.1016/j.psychres.2008.06.028

Psychiatry Research
Volume 169, Issue 2 , Pages 113-117 , 30 September 2009