Psychiatry Research
Volume 170, Issue 2 , Pages 245-251 , 30 December 2009

Decreased expression of serotonin 1A receptor in the dentate gyrus in association with chronic mild stress: A rat model of post-stroke depression

  • Shao-hua Wang

      Affiliations

    • Department of Neurology and Institution of Cerebral Vascular Disease, ZhongDa Hospital, Southeast University, Nanjing, China
    • Tel.: +86 25 83285148; fax: +86 25 83285132.
    • ,
  • Zhi-jun Zhang

      Affiliations

    • Department of Neurology and Institution of Cerebral Vascular Disease, ZhongDa Hospital, Southeast University, Nanjing, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 25 83272023; fax: +86 25 83285132.
    • ,
  • Yi-jing Guo

      Affiliations

    • Department of Neurology and Institution of Cerebral Vascular Disease, ZhongDa Hospital, Southeast University, Nanjing, China
    • ,
  • Gao-jun Teng

      Affiliations

    • Institution of Molecular Imaging, Southeast University, Nanjing, China
    • ,
  • Bao-an Chen

      Affiliations

    • Department of Neurology and Institution of Cerebral Vascular Disease, ZhongDa Hospital, Southeast University, Nanjing, China

Received 23 July 2007 ,Revised 11 February 2008 ,Accepted 20 July 2008.

References 

  1. Barden N, Reul JM, Holsboer F. Do antidepressants stabilize mood through actions on the hypothalamic–pituitary–adrenocortical system?. Trends in Neuroscience. 1995;18:6–11
  2. Drevets WC, Frank E, Price JC, Kupfer DJ, Holt D, Greer PJ, et al. PET imaging of serotonin 1A receptor binding in depression. Biological Psychiatry. 1999;46:1375–1387
  3. Duman RS, Malberg J, Thome J. Neural plasticity to stress and antidepressant treatment. Biological Psychiatry. 1999;46:1181–1191
  4. Ferrarese C, Bassi S, Frattola L, Locatelli P, Piolti R, Trabucchi M. Different patterns of CSF neurotransmitter metabolism in patients with left or right hemispheric stroke. Acta Neurologica Scandinavica. 1986;73:581–585
  5. Finkbeiner S. CREB couples neurotrophin signals to survival messages. Neuron. 2000;25:11–14
  6. Gould E, Reeves AJ, Graziano MS, Gross CG. Neurogenesis in the neocortex of adult primates. Science. 1999;286:548–552
  7. Hackett ML, Yapa C, Parag V, Anderson CS. Frequency of depression after stroke: a systematic review of observational studies. Stroke. 2005;36:1330–1340
  8. Haddjeri N, Blier P, de Montigny C. Long-term antidepressant treatments result in a tonic activation of the forebrain 5HT1A receptors. Journal of Neurochemistry. 1998;18:10150–10160
  9. Hall MD, el Mestikawy S, Emerit MB, Pichat L, Hamon M, Gozlan H. [3H]8-hydroxy-2-(di-n-propylamino)tetralin binding to pre-and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain. Journal of Neurochemistry. 1985;44:1685–1696
  10. Katz RJ, Roth KA, Carroll BJ. Acute and chronic stress effects on open field activity in the rat: implications for a model of depression. Neuroscience and Biobehavioral Reviews. 1981;5:247–251
  11. Koizumi J, Yoshida Y, Nakazawa T. Experimental studies of ischemic brain edema: a new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Japanese Journal of Stroke. 1986;8:1–8
  12. Kreiss DS, Lucki I. Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo. Journal of Pharmacology and Experimental Therapeutics. 1995;274:866–876
  13. Lai IC, Hong CJ, Tsai SJ. Expression of cAMP response element-binding protein in major depression before and after antidepressant treatment. Neuropsychobiology. 2003;48:182–185
  14. Le Poul E, Boni C, Hanoun N, Laporte AM, Laaris N, Chauveau J, et al. Differential adaptation of brain 5-HT1A and 5-HT1B receptors and 5-HT transporter in rats treated chronically with fluoxetine. Neuropharmacology. 2000;39:110–122
  15. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) method. Methods. 2001;25:402–408
  16. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20:84–91
  17. Lopez-Figueroa AL, Norton CS, Lopez-Figueroa MO, Armellini-Dodel D, Burke S, Akil H. Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia. Biological Psychiatry. 2004;55:225–233
  18. Lopez JF, Chalmers DT, Little KY, Watson SJ. Regulation of 5HT1Areceptor, glucocorticoid and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression. Biological Psychiatry. 1998;43:547–573
  19. Lopez JF, Liberzon I, Vazquez DM, Young EA, Watson SJ. Serotonin 1A receptor messenger RNA regulation in the hippocampus after acute stress. Biological Psychiatry. 1999;45:934–937
  20. Meijer OC, de Kloet ER. Corticosterone suppresses the expression of 5-HT1A receptor mRNA in rat dentate gyrus. European Journal of Pharmacology. 1994;266:255–261
  21. Meijer OC, de Kloet ER. Corticosterone and 5-HT neurotransmission in the hippocampus: functional implications of central corticosteroid receptor diversity. Critical Reviews Neurobiology. 1998;12:1–20
  22. Meltzer HY, Lowy MT. The serotonin hypothesis of depression. In:  Meltzer HY editors. Psychopharmacology: The Third Generation of Progress. New York: Raven Press; 1987;p. 513–526
  23. Mendez J, Kadia TM, Somayazula RK, El-Badawi KI, Cowen DS. Differential coupling of serotonin 5-HT1A and 5-HT1B receptors to activation of ERK2 and inhibition of adenylyl cyclase in transfected CHO cells. Journal of Neurochemistry. 1999;73:162–168
  24. Mongeau R, Blier P, de Montigny C. The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments. Brain Research Reviews. 1997;23:145–195
  25. Mrsulja BB, Mrsulja BJ, Spatz M, Klatzo I. Brain serotonin alter experimental vascular occlusion. Neurology. 1976;26:785–787
  26. Nakagawa S, Kim JE, Lee R. CREB plays a critical role in the survival of newborn cells in the adult hippocampus. Society of Neuroscience Abstract. 2000;26:2317
  27. Neumaier JF, Sexton TJ, Hamblin MW, Beck SG. Corticosteroids regulate 5-HT(1A) but not 5-HT(1B) receptor mRNA in rat hippocampus. Brain Research. Molecular Brain Research. 2000;82:65–73
  28. Nibuya M, Morinobu S, Duman RS. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. Journal of Neuroscience. 1995;15:7539–7547
  29. Nibuya M, Nestler EJ, Duman RS. Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. Journal of Neuroscience. 1996;16:2365–2372
  30. Papp M, Nalepa I, Antkiewicz-Michaluk L, Sanchez C. Behavioural and biochemical studies of citalopram and WAY 100635 in rat chronic mild stress model. Pharmacology, Biochemistry, and Behavior. 2002;72:465–474
  31. Raap DK, Evans S, Garcia F, Li Q, Muma NA, Wolf WA. Daily injections of fluoxetine induce dose-dependent desensitization of hypothalamic 5-HT1A receptors: reductions in neuroendocrine responses to 8-OH-DPAT and in levels of Gz and Gi proteins. Journal of Pharmacology and Experimental Therapeutics. 1999;288:98–106
  32. Radley JJ, Jacobs BL. 5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus. Brain Research. 2002;955:264–267
  33. Robinson RG, Shoemaker WJ, Schlumpf M, Valk T, Bloom FE. Effect of experimental cerebral infarction in rat brain on catecholamines and behavior. Nature. 1975;255:332–334
  34. Sargent PA, Kjaer KH, Bench CJ, Rabiner EA, Messa C, Meyer J. Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment. Archives of General Psychiatry. 2000;57:174–180
  35. Shen CP, Tsimberg Y, Salvadore C, Meller E. Activation of Erk and JNK MAPK pathways by acute swim stress in rat brain regions. BMC Neuroscience. 2004;5:36
  36. Shirayama Y, Chen AC, Nakagawa S, Russell DS, Duman RS. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. Journal of Neuroscience. 2002;22:3251–3261
  37. Starkstein SE, Robinson RG, Berthier ML, Parikh RM, Price TR. Differential mood changes following basal ganglia versus thalamic lesions. Archives of Neurology. 1988;45:725–730
  38. Stokes PE. The potential role of excessive cortisol induced by HPA hyperfunction in the pathogenesis of depression. European Neuropsychopharmacology. 1995;(5 (Suppl.):77–82
  39. Willner P. Chronic Mild Stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology. 2005;52:90–110
  40. Willner P, Towell A, Sampson D, Sophokleous S, Muscat R. Reduction of sucrose preference by chronic unpredictable mild stress and its restoration by a tricyclic antidepressant. Psychopharmacology. 1987;93:358–364
  41. Willner P. Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology. 1997;134:319–329
  42. Yuan J, Yankner BA. Apoptosis in the nervous system. Nature. 2000;407:802–809

PII: S0165-1781(08)00226-6

doi: 10.1016/j.psychres.2008.07.006

Psychiatry Research
Volume 170, Issue 2 , Pages 245-251 , 30 December 2009

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