Psychiatry Research
Volume 170, Issue 2 , Pages 241-244 , 30 December 2009

Plasma homovanillic acid in adolescents with bulimia nervosa

  • Josefina Castro-Fornieles

      Affiliations

    • Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Biomedical Research Center in Mental Health Network, CIBERSAM Barcelona, Spain
    • IDIBAPS (Institut d'Investigacions Biomèdiques August Pi Sunyer), Barcelona, Spain
    • Department of Psychiatry and Psychobiology, Health Sciences Division, University of Barcelona, Spain
    • Corresponding Author InformationCorresponding author. Department of Child and Adolescent Psychiatry and Psychology, Hospital Clínic Universitari, Villarroel 170, Barcelona 08036, Spain. Tel./fax: +34 93 2279974.
    • ,
  • Ramón Deulofeu

      Affiliations

    • Department of Clinical Chemistry, Center of Biological Diagnosis, Hospital Clínic Universitari of Barcelona, Spain
    • IDIBAPS (Institut d'Investigacions Biomèdiques August Pi Sunyer), Barcelona, Spain
    • ,
  • Esteve Martínez-Mallen

      Affiliations

    • Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Biomedical Research Center in Mental Health Network, CIBERSAM Barcelona, Spain
    • ,
  • Immaculada Baeza

      Affiliations

    • Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Biomedical Research Center in Mental Health Network, CIBERSAM Barcelona, Spain
    • ,
  • Lorena Fernández

      Affiliations

    • Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Biomedical Research Center in Mental Health Network, CIBERSAM Barcelona, Spain
    • ,
  • Luisa Lázaro

      Affiliations

    • Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Biomedical Research Center in Mental Health Network, CIBERSAM Barcelona, Spain
    • IDIBAPS (Institut d'Investigacions Biomèdiques August Pi Sunyer), Barcelona, Spain
    • ,
  • Josep Toro

      Affiliations

    • Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Biomedical Research Center in Mental Health Network, CIBERSAM Barcelona, Spain
    • Department of Psychiatry and Psychobiology, Health Sciences Division, University of Barcelona, Spain
    • ,
  • Montserrat Vila

      Affiliations

    • Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Biomedical Research Center in Mental Health Network, CIBERSAM Barcelona, Spain
    • ,
  • Miquel Bernardo

      Affiliations

    • Psychiatry Department, Institute of Neurosciences, Hospital Clínic Universitari, Biomedical Research Center in Mental Health Network, CIBERSAM Barcelona, Spain
    • IDIBAPS (Institut d'Investigacions Biomèdiques August Pi Sunyer), Barcelona, Spain
    • Department of Psychiatry and Psychobiology, Health Sciences Division, University of Barcelona, Spain

Received 10 July 2007 ,Revised 1 October 2007 ,Accepted 12 June 2008.

References 

  1. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. 4th edition. Washington, DC: American Psychiatric Press; 1994;
  2. Amin F, Davidson M, Kahn RS, Schmeidler J, Stern R, Knott PJ, et al. Assessment of the central dopaminergic index of plasma HVA in schizophrenia. Schizophrenia Bulletin. 1995;21:53–66
  3. Avena NM, Rada P, Moise N, Hoebel BG. Sucrose sham feeding on a binge schedule releases accumbens dopamine repeatedly and eliminates the acetylcholine satiety response. Neuroscience. 2006;139:813–820
  4. Bassareo V, Di Chiara G. Modulation of feeding-induced activation of mesolimbic dopamine transmission by appetitive stimuli and its relation to motivational state. European Journal of Neuroscience. 1999;11:4389–4397
  5. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Archives of General Psychiatry. 1961;4:561–571
  6. Beck AT, Steer RA, Brown GK. Beck Depression Inventory—Second Edition Manual. Sydney: The Psychological Corporation; 1996;
  7. Bowers MB, Swigar ME, Hoffman FJ, Goicoechea N. Characteristics of patients with the highest plasma catecholamine metabolite levels. American Journal of Psychiatry. 1988;145:246–248
  8. Bowers MB, Mazure CM, Greenfeld DG. Elevated plasma level monoamine metabolites in eating disorders. Psychiatry Research. 1994;52:11–15
  9. Brambilla F. Aetiopathogenesis and pathophysiology of bulimia nervosa: biological bases and implications for treatment. CNS Drugs. 2001;15:119–136
  10. Brambilla F, Bellodi L, Arancio C, Ronchi P, Limonta D. Central dopaminergic function in anorexia and bulimia nervosa: a psychoneuroendocrine approach. Psychoneuroendocrinology. 2001;26:393–409
  11. Breier A, Davis OR, Buchanan RW, Moricle LA, Munson RC. Effects of metabolic perturbation on plasma homovanillic acid in schizophrenia. Archives of General Psychiatry. 1993;50:541–550
  12. Castro J, Toro J, Salamero M, Guimerà E. The Eating Attitudes Test: validation of the Spanish version. Psychological Assessment. 1991;7:175–190
  13. Castro-Fornieles J, Deulofeu R, Baeza I, Casulà V, Saura B, Lázaro L, et al. Psychopathological and nutritional correlates of plasma homovanillic acid in adolescents with anorexia nervosa. Journal of Psychiatric Research. 2008;42:213–220
  14. Chang W, Scheinin M, Burns S, Linnoila M. Rapid and simple determination of homovanilic acid in plasma using high performance liquid chromatography with electrochemical detection. Acta Pharmacologica et Toxicologica. 1983;53:275–279
  15. Chang WH, Chen TY, Lin SK, Lung FW, Lin WL, Hu WH, et al. Plasma catecholamine metabolites in schizophrenics. Biological Psychiatry. 1990;27:510–518
  16. Coccaro EF, Hirsch SL, Stein MA. Plasma homovanilic acid correlates inversely with history of learning problems in healthy volunteer and personality disordered subject. Psychiatry Research. 2007;149:297–302
  17. Devanand DP, Bowers MB, Hoffman FJ, Nelson JC. Elevated plasma homovanillic acid in depressed females with melancolia and psychosis. Psychiatry Research. 1985;15:1–4
  18. Fairburn CG, Wilson GT. Binge eating. In: Nature, Assessment and Treatment. New York: The Guilford Press; 1993;
  19. Friedhoff AJ, Amin F. Plasma HVA as a tool to investigate presynaptic brain dopaminergic activity. In:  Friedhoff AJ,  Amin F editor. Plasma Homovanillic Acid in Schizophrenia. Implications for Presynaptic Dopamine Dysfunction. Washington, DC: American Psychiatric Press, Inc; 1997;p. 1–16
  20. Garner DM, Garfinkel PE. The Eating Attitudes Test: an index of the symptoms of anorexia nervosa. Psychological Medicine. 1979;9:273–279
  21. Inoue K, Kiriike N, Okuno M, Fujisaki Y, Kurioka M, Iwasaki S, et al. Prefrontal and striatal dopamine metabolism during enhanced rebound hyperphagia induced by space restriction—a rat model of binge eating. Biological Psychiatry. 1998;44:1329–1336
  22. Jimerson DC, Lesem MD, Kaye WH, Brewerton TD. Low serotonin and dopamine metabolite concentrations in cerebrospinal fluid from bulimic patients with frequent binge episodes. Archives of General Psychiatry. 1992;49:132–138
  23. Kaye WH, Ballenger JC, Lydiard RB, Stuart GW, Laraia MT, O'Neil P, et al. CSF monoamine levels in normal-weight bulimia: evidence for abnormal noradrenergic activity. American Journal of Psychiatry. 1990;147:225–229
  24. Kaye WK, Greeno CG, Moss H, Fernstrom J, Fernstrom M, Lilenfeld LR, et al. Alterations in serotonin activity and psychiatric symptoms after recovery from bulimia nervosa. Archives General Psychiatry. 1998;55:927–935
  25. Kaye WK, Frank GKW, McConaha C. Altered dopamine activity after recovery from restricting-type anorexia nervosa. Neuropsychopharmacology. 1999;21:503–506
  26. Kennedy SH, Davis BA, Brown GM, Ford CG, d'Souza J. Effects of chronic brofaromine administration on biogenic amines including sulphatoxymelatonin and acid metabolites in patients with bulimia nervosa. Neurochemistry Research. 1993;18:1281–1285
  27. Markianos M, Alevizos B, Hatzimanolis J, Stefanis C. Effects of monoamine oxidase A inhibition on plasma biogenic metabolites in depressed patients. Psychiatry Research. 1994;52:259–264
  28. Rada P, Avena NM, Hoebel BG. Daily bingeing on sugar repeatedly releases dopamine in the accumbens shell. Neuroscience. 2005;134:737–744
  29. Rothschild AJ, Schatzberg AF, Langlais PJ, Lerbinger JE, Miller MM, Cole JO. Psychotic and nonpsychotic depressions, I: comparison of plasma catecholamines and cortisol measures. Psychiatry Research. 1987;20:143–153
  30. Salzman C, Jimerson D, Vasile R, Watsky E, Gerber J. Response to SSRI antidepressants correlates with reduction in plasma HVA: pilot study. Biological Psychiatry. 1993;34:569–571
  31. Schmidt U. Aetiology of eating disorders in the 21st century. New answers to old questions. European Child and Adolescent Psychiatry. 2003;12(Suppl. 1):30–37
  32. Stern RG, Kahn RS, Davidson M. Review of plasma HVA studies in schizophrenia. In:  Friedhoff AJ,  Amin F editor. Plasma Homovanillic Acid in Schizophrenia. Implications for Presynaptic Dopamine Dysfunction. Washington, DC: American Psychiatric Press, Inc; 1997;p. 27–42
  33. Sumiyoshi T, Hasegawa M, Jayathilake K, Meltzer HY. Sex differences in plasma homoanillic acid levels in schizophrenia and normal controls: relation to neuroleptic resistance. Biological Psychiatry. 1997;41:560–566
  34. Ueda N, Yoshimura R, Shinkai K, Nakamura J. Plasma levels of catecholamine metabolites predict the response to sulpiride or fluvoxamine in major depression. Pharmacopsychiatry. 2002;35:175–181
  35. Volkow ND, Wang GJ, Fowler JS, Logan J, Jayne M, Franceschi D, et al. “Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect. Synapse. 2002;44:175–180
  36. Volkow ND, Wang GJ, Maynard L, Jayne M, Fowler JS, Zhu W, et al. Brain dopamine is associated with eating behaviors in humans. International Journal of Eating Disorders. 2003;33:136–142
  37. Yoshimura R, Ueda N, Shinkai K, Nakamura J. Plasma levels of homovanillic acid and the response to risperidone in first episode untreated acute schizophrenia. International Clinical Psychopharmacology. 2003;18:107–111
  38. Zhang ZJ, Peet M, Ramchand CN, Shah S, Reynolds GP. Plasma homovanillic acid in untreated schizophrenia — relationship with symptomatology and sex. Journal of Psychiatric Research. 2001;35:23–28

PII: S0165-1781(09)00029-8

doi: 10.1016/j.psychres.2008.06.046

Psychiatry Research
Volume 170, Issue 2 , Pages 241-244 , 30 December 2009

Article Tools

* Image Usage & Resolution