Psychiatry Research
Volume 175, Issue 1 , Pages 160-164 , 30 January 2010

Genetic risk, parent–child relations, and antisocial phenotypes in a sample of African-American males

  • Kevin M. Beaver

      Affiliations

    • College of Criminology and Criminal Justice, Florida State University, Tallahassee, FL 32306, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 850 644 9180; fax: +1 850 644 9614.
    • ,
  • Ashley Sak

      Affiliations

    • College of Criminology and Criminal Justice, Florida State University, Tallahassee, FL 32306, United States
    • ,
  • Jamie Vaske

      Affiliations

    • Division of Criminal Justice, University of Cincinnati, Cincinnati, OH 45221-0389, United States
    • ,
  • Jessica Nilsson

      Affiliations

    • College of Criminology and Criminal Justice, Florida State University, Tallahassee, FL 32306, United States

Received 10 August 2008 ,Revised 15 January 2009 ,Accepted 22 January 2009.

References 

  1. Arseneault L, Moffitt TE, Caspi A, Taylor A, Rijsdijk FV, Jaffee SR, et al. Strong genetic effects on cross-situational antisocial behaviour among 5-year-old children according to mothers, teachers, examiner-observers, and twins' self-reports. Journal of Child Psychology and Psychiatry. 2003;44:832–848
  2. Bakermans-Kranenburg MJ, van IJzendoorn MH. Gene–environment interaction of the dopamine D4 receptor (DRD4) and observed maternal insensitivity predicting externalizing behavior in preschoolers. Developmental Psychobiology. 2006;48:406–409
  3. Beaver KM, Wright JP, DeLisi M, Walsh A, Vaughn MG, Boisvert D, et al. A gene×gene interaction between DRD2 and DRD4 is associated with conduct disorder and antisocial behavior in males. Behavioral and Brain Functions. 2007;3:30
  4. Cadoret RJ, Langbehn D, Caspers K, Troughton EP, Yucuis R, Sandhu HK, et al. Associations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit, and conduct disorder in an adoptee population. Comprehensive Psychiatry. 2003;44:88–101
  5. Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, et al. Role of genotype in the cycle of violence in maltreated children. Science. 2002;297:851–854
  6. Chang FM, Kidd JR, Livak KJ, Pakstis AJ, Kidd KK. The world-wide distribution of allele frequencies at the human D4 receptor locus. Human Genetics. 1996;98:91–101
  7. DeLisi M, Regoli B. Race, conventional crime, and criminal justice: the declining importance of skin color. Journal of Criminal Justice. 1999;27:549–557
  8. Farrington D, Loeber R, Stouthamer-Loeber M, VanKammen WB, Schmidt L. Self-reported delinquency and a combined delinquency seriousness scale based on boys, mothers, and teachers: concurrent and predictive validity for African-Americans and Caucasians. Criminology. 1996;34:493–517
  9. Frazzetto G, Di Lorenzo G, Carola V, Proietti L, Sokolowska E, Siracusano A, et al. Early trauma and increased risk for physical aggression during adulthood: the moderating role of MAOA genotype. Plos One. 2007;2:e486
  10. Foley DL, Eaves LJ, Wormley B, Silberg JL, Maes HH, Kuhn J, et al. Childhood adversity, monoamine oxidase A genotype, and risk for conduct disorder. Archives of General Psychiatry. 2004;61:738–744
  11. Gelernter J, Kranzler H, Cubells JF. Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects. Human Genetics. 1997;101:243–246
  12. Gelernter J, Kranzler H, Cubells JF, Ichinose H, Nagatsu T. DRD2 allele frequencies and linkage disequilibria, including the -141CIns/Del promoter polymorphism, in European-American, African-American, and Japanese subjects. Genomics. 1998;51:21–26
  13. Guo G, Roettger ME, Shih JC. Contributions of the DAT1 and DRD2 genes to serious and violent delinquency among adolescents and young adults. Human Genetics. 2007;121:125–136
  14. Guo G, Wilhelmsen K, Hamilton N. Gene-lifecourse interaction for alcohol consumption in adolescence and young adulthood: five monoamine genes. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2007;144B:417–423
  15. Haberstick BC, Lessem JM, Hopfer CJ, Smolen A, Ehringer MA, Timberlake D, et al. Monoamine oxidase A (MAOA) and antisocial behaviors in the presence of childhood and adolescent maltreatment. American Journal of Medical Genetics. 2005;135B:59–64
  16. Harris KM, Florey F, Tabor J, Bearman PS, Jones J, Udry JR. The National Longitudinal Study of Adolescent Health: Research Design. 2003;[www document]. URL: http://www.cpc.unc.edu/projects/addhealth/design
  17. Haynie DL. Delinquent peers revisited: does network structure matter?. American Journal of Sociology. 2001;106:1013–1057
  18. Hopfer CJ, Timberlake D, Haberstick B, Lessem JM, Ehringer MA, Smolen A, et al. Genetic influences on quantity of alcohol consumed by adolescents and young adults. Drug and Alcohol Dependence. 2005;78:187–193
  19. Huizinga D, Haberstick BC, Smolen A, Menard S, Young SE, Corley RP, et al. Childhood maltreatment, subsequent antisocial behavior, and the role of monoamine oxidase A genotype. Biological Psychiatry. 2006;60:677–683
  20. Jaffee SR, Caspi A, Moffitt TE, Dodge KA, Rutter M, Taylor A, et al. Nature×nurture: genetic vulnerabilities interact with physical maltreatment to promote conduct problems. Developmental Psychopathology. 2005;17:67–84
  21. Jolliffe D, Farrington DP, Hawkins DP, Catalano RF, Hill KG, Kosterman R. Predictive, concurrent, prospective and retrospective validity of self-reported delinquency. Criminal Behaviour and Mental Health. 2003;13:179–197
  22. Kendler KS, Kessler RC, Walters EE, MacClean C, Neale MC, Heath AC, et al. Stressful life events, genetic liability, and onset of an episode of major depression in women. American Journal of Psychiatry. 1995;152:833–842
  23. Kim-Cohen J, Caspi A, Taylor A, Williams B, Newcombe R, Craig IW, et al. MAOA, maltreatment, and gene–environment interaction predicting children's mental health: new evidence and a meta-analysis. Molecular Psychiatry. 2006;11:903–913
  24. Mason DA, Frick PJ. The heritability of antisocial behavior: a meta-analysis of twin and adoption studies. Journal of Psychopathology and Behavioral Assessment. 1994;16:301–323
  25. Miles DR, Carey G. Genetic and environmental architecture of human aggression. Journal of Personality and Social Psychology. 1997;72:207–217
  26. Moffitt TE. The new look of behavioral genetics in developmental psychopathology: gene–environment interplay in antisocial behaviors. Psychological Bulletin. 2005;131:533–554
  27. Nilsson KW, Sjoberg RL, Damberg M, Alm PO, Ohrvik J, Leppert J, et al. Role of the serotonin transporter gene and family function in adolescent alcohol consumption. Alcoholism: Clinical and Experimental Research. 2005;29:564–570
  28. Resnick MD, Bearman PS, Blum RW, Bauman KE, Harris KM, Jones J, et al. Protecting adolescents from harm: findings from the National Longitudinal Study of Adolescent Health. Journal of the American Medical Association. 1997;278:823–832
  29. Rhee SH, Waldman ID. Genetic and environmental influences on antisocial behavior: a meta-analysis of twin and adoption studies. Psychological Bulletin. 2002;128:490–529
  30. Ritchey FJ. The Statistical Imagination: Elementary Statistics for the Social Sciences. New York: McGraw-Hill; 2000;
  31. Rutter M. Genes and Behavior: Nature–nurture Interplay Explained. Malden, MA: Blackwell; 2006;
  32. Schreck CJ, Fisher BS, Miller JM. The social context of violent victimization: a study of the delinquent peer effect. Justice Quarterly. 2004;21:23–47
  33. Tuvblad C, Grann M, Lichtenstein P. Heritability for adolescent antisocial behavior differs with socioeconomic status: gene–environment interaction. Journal of Child Psychological and Psychiatry. 2006;47:734–743
  34. Udry JR. The National Longitudinal Study of Adolescent Health (Add Health), Waves I and II, 1994–1996; Wave III, 2001–2002 [machine-readable data file and documentation]. Chapel Hill, NC: Carolina Population Center, University of North Carolina at Chapel Hill; 2003;
  35. Widom CS, Brzustowicz LM. MAOA and the “cycle of violence:” Childhood abuse and neglect, MAOA genotype, and risk for violent and antisocial behavior. Biological Psychiatry. 2006;60:684–689
  36. Young SE, Smolen A, Hewitt JK, Haberstick BC, Stallings MC, Corley RP, et al. Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: failure to confirm in adolescent patients. American Journal of Psychiatry. 2006;163:1019–1025

PII: S0165-1781(09)00054-7

doi: 10.1016/j.psychres.2009.01.024

Psychiatry Research
Volume 175, Issue 1 , Pages 160-164 , 30 January 2010

Article Tools