A detailed association analysis between the tryptophan hydroxylase 2 (TPH2) gene and autism spectrum disorders in a Japanese population

Egawa, Jun; Watanabe, Yuichiro; Nunokawa, Ayako; Endo, Taro; Kaneko, Naoshi; Tamura, Ryu; Sugiyama, Toshiro; Someya, Toshiyuki

doi:10.1016/j.psychres.2011.09.001

« Previous Next »Psychiatry Research
Volume 196, Issue 2 , Pages 320-322, 30 April 2012

A detailed association analysis between the tryptophan hydroxylase 2 (TPH2) gene and autism spectrum disorders in a Japanese population

Jun Egawa
- Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Yuichiro Watanabe
- Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
- Health Administration Center, Headquarters for Health Administration, Niigata University, Niigata, Japan
- Corresponding author at: Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori-ichibancho, Chuo-ku, Niigata 951-8510, Japan. Tel.: +81 25 227 2213; fax: +81 25 227 0777.
Ayako Nunokawa
- Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Taro Endo
- Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Naoshi Kaneko
- Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Ryu Tamura
- Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Toshiro Sugiyama
- Department of Child and Adolescent Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan
Toshiyuki Someya
- Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

Received 26 April 2011; received in revised form 11 August 2011; accepted 1 September 2011. published online 23 February 2012.

Abstract

We conducted a detailed association analysis between the tryptophan hydroxylase 2 gene and autism spectrum disorders in a Japanese population using 19 markers, including tagging single nucleotide polymorphisms and a novel missense variation, p.R225Q, identified through exon resequencing. However, we failed to obtain supportive evidence for an association.

Keywords: Missense variation, Resequencing, Tagging SNPs